Some Data on Steroid Transformation in Human Epididymal and Prostatic Tissue

2015 ◽  
pp. 265-266
Author(s):  
I. F. Sommerville
Keyword(s):  
Prostatic Tissue ◽  
Steroid Transformation

673: Utility of Resection of Additional Peri-Prostatic Tissue in Patients Undergoing Radical Prostatectomy

2006 ◽  
Vol 175 (4S) ◽  
pp. 217-217
Author(s):  
Ganesh V. Raj ◽  
Rahul Iyer ◽  
Fernando J. Bianco ◽  
Bertrand Guillonneau ◽  
Peter T. Scardino ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostatic Tissue

scholarly journals Ectopic prostatic tissue with eosinophilic epithelial metaplasia in anterior urethra: A case report

2021 ◽  
Vol 24 ◽  
pp. 200500
Author(s):  
Dorian Dikov ◽  
Maria Koleva ◽  
Elena Gerakova ◽  
Veselin Belovejdov
Keyword(s):  
Case Report ◽  
Prostatic Tissue ◽  
Anterior Urethra ◽  
Epithelial Metaplasia

scholarly journals Can mean ADC value and ADC ratio of benign prostate tissue to prostate cancer assist in the prediction of clinically significant prostate cancer within the PI-RADSv2 scoring system?

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Samar Ramzy Ragheb ◽  
Reem Hassan Bassiouny
Keyword(s):  
Prostate Cancer ◽  
Sensitivity And Specificity ◽  
Gleason Score ◽  
Treatment Strategies ◽  
Serum Levels ◽  
Prostatic Tissue ◽  
Histopathological Analysis ◽  
Adc Value ◽  
The Mean ◽  
Clinically Significant

Abstract Background The aim of this study is to investigate whether quantitative DW metrics can provide additive value to the reliable categorization of lesions within existing PI-RADSv2 guidelines. Fifty-eight patients with clinically suspicious prostate cancer who underwent PR examination, PSA serum levels, sextant TRUS-guided biopsies, and bi-parametric MR imaging were included in the study. Results Sixty-six lesions were detected by histopathological analysis of surgical specimens. The mean ADC values were significantly lower in tumor than non-tumor tissue. The mean ADC value inversely correlated with Gleason score of tumors with a significant p value < 0.001.Conversely, a positive relationship was found between the ADC ratio (ADC of benign prostatic tissue to prostate cancer) and the pathologic Gleason score with a significant elevation of the ADC ratio along with an increase of the pathologic Gleason score (p < 0.001). ROC curves constructed for the tumor ADC and ADC ratio helped to distinguish pathologically aggressive (Gleason score ≥ 7) from non-aggressive (Gleason score ≤ 6) tumors and to correlate it with PIRADSv2 scoring to predict the presence of clinically significant PCA (PIRADSv2 DW ≥ 4). The ability of the tumor ADC and ADC ratio to predict highly aggressive tumors (GS> 7) was high (AUC for ADC and ADC ratio, 0.946 and 0.897; p = 0.014 and 0.039, respectively). The ADC cut-off value for GS ≥ 7 was < 0.7725 and for GS ≤ 6 was > 0.8620 with sensitivity and specificity 97 and 94%. The cutoff ADC ratio for predicting (GS > 7) was 1.42 and for GS ≤ 6 was > 1.320 with sensitivity and specificity 97 and 92%. By applying this ADC ratio cut-off value the sensitivity and specificity of reader 1 for correct categorization of PIRADSv2 DW > 4 increased from 90 and 68% to 95 and 90% and that of reader 2 increased from 94 and 88% to 97 and 92%, respectively. Conclusion Estimation of DW metrics (ADC and ADC ratio between benign prostatic tissue and prostate cancer) allow the non-invasive assessment of biological aggressiveness of prostate cancer and allow reliable application of the PIRADSv2 scoring to determine clinically significant cancer (DW score > 4) which may contribute in planning initial treatment strategies.

Prostatic tissue DHT levels and 5alpha-reductase activity: Effect of GNRH analogs

1987 ◽  
Vol 28 ◽  
pp. 12
Author(s):  
G. Forti ◽  
M. Cocconi ◽  
G. Moneti ◽  
S. Zopp'i ◽  
A. Natali ◽  
...  
Keyword(s):  
Reductase Activity ◽  
Prostatic Tissue ◽  
Gnrh Analogs ◽  
Activity Effect

Detection of prostatic tissue and seminal plasma peptides reacting with human seminal fluid acid phosphatase antibodies

1986 ◽  
Vol 18 (11) ◽  
pp. 1005-1013 ◽  
Author(s):  
Radosława Kuciel ◽  
Izydor Apostoł ◽  
Ewa Wasylewska ◽  
Włodzimierz S. Ostrowski ◽  
Iga Steuden ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Seminal Plasma ◽  
Seminal Fluid ◽  
Prostatic Tissue

5α-Reductase activity in stroma and epithelium of rat prostate and epididymis. A contribution to elucidation of the mechanism for development of hyperplastic growth of prostatic tissue

1983 ◽  
Vol 103 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Ole Djøseland ◽  
Nicholas Bruchovsky ◽  
Paul S. Rennie ◽  
Navdeep Otal ◽  
Sian Høglo
Keyword(s):  
Enzyme Activity ◽  
Specific Activity ◽  
Reductase Activity ◽  
Major Change ◽  
Growth Stimulation ◽  
Total Activity ◽  
Prostatic Tissue ◽  
Ventral Prostate ◽  
Total Enzyme Activity ◽  
Abnormal Growth

Abstract. The 5α-reductase activity was assayed in homogenates of stroma and epithelium in the rat ventral prostate and epididymis. Samples consisting of 0.3 mg/ml tissue protein in TES buffer, pH 7.0 were incubated at 37°C for 30 min in the presence of 50 nm [1,2-3H]testosterone and a NADPH-generating system started with 5 × 10−4 m NADP. The yield of 5α-reduced metabolites, as established by using thin-layer chromatography, gave an estimate of enzyme activity. Whereas the specific activity of 5α-reductase was highest in prostatic stroma and epididymal epithelium, most of the total enzyme activity was associated with the epithelium in both the prostate and epididymis. The effect of dihydrotestosterone on specific activity of 5α-reductase was studied by administering the hormone to 7-day castrated rats. In prostate, the specific activity of both stromal and epithelium forms of the enzyme reached a maximum after 4 days of treatment. In epididymis only the epithelial form of 5α-reductase underwent a major change in specific activity, the latter peaking after 8–12 days of treatment. Furthermore, while the total activity of 5α-reductase in the prostatic tissue fractions could be induced by as much as 4-fold the normal control values, the epididymal enzyme could not be induced above the normal level either in the stroma or the epithelium. This may explain the relative resistance of epididymis to abnormal growth stimulation under the influence of hormones.

The concentration of thiamphenicol in seminal fluid and prostatic tissue

1978 ◽  
Vol 4 (1) ◽  
pp. 65-71 ◽  
Author(s):  
T. A. Plomp ◽  
J. J. Mattelaer ◽  
R. A. A. Maes
Keyword(s):  
Seminal Fluid ◽  
Prostatic Tissue
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