Pulmonary Haemodynamics in Bronchogenic Cancer Before and After Lung Resection

Author(s):  
V. Je�ek
2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Francesc Gual-Capllonch ◽  
Fredzzia Graterol ◽  
Jordi Soler Majoral ◽  
Ioana Bancu ◽  
Elena Ferrer-Sistach ◽  
...  

Abstract Background and Aims Haemodynamic cardiac changes in haemodialysis are associated with adverse cardiovascular outcomes and and they are difficult to measure. Systolic pulmonary artery pressure (SPAP) and right heart adaptation in relation to pre-existing preload are often disregarded. To determine volume-related changes in the pulmonary-right ventricle (RV) unit and the preload-dependence of its components, we analysed pulmonary haemodynamics and right ventricular performance, taking advantage of the plasma volume removal associated to haemodialysis (HD). Methods and results Fifty-three stable patients on chronic HD with LVEF >50% and without heart failure were recruited (mean age 63.0±12.4 years; 31.2% women; hypertension in 89% and diabetes in 53%) and evaluated just before and after HD (mean ultrafiltration volume 2.4±0.7l). SPAP from both times were available in 39 patients. After HD, SPAP decreased (42.2±12.6 to 33.7±11.6 mmHg, p<0.001) without modification of non-invasive pulmonary vascular resistance (1.75±0.44 to 1.75±0.40 eWU, p=0.94). Age and drop in the E/e’ ratio were the variables associated with greater reduction in PASP (p=0.022 and p=0.049, respectively). A significant reduction of right chamber sizes was observed, along with a diminution in measures of RV contractility, excluding RV longitudinal strain. Functional tricuspid regurgitation (FTR) diminution was observed in 26% of patients, occurring in every case with more than mild FTR. On multivariate analyses, left atrial size was the only predictor of pulmonary hypertension (defined as SPAP >40 mmHg) (OR 1.29 (1.07–1.56), p=0.006). Conclusion Rapid volemic changes determined by rapid fluid removal during hemodialysis; may affect FTR grading, RV size and contractility, with RV longitudinal strain being less variable than conventional parameters. SPAP decreases after HD, and this reduction is related to age and greater diminution of the E/e′ ratio.


Respiration ◽  
1970 ◽  
Vol 27 (1) ◽  
pp. 42-50 ◽  
Author(s):  
V. Ježek ◽  
A. Ouředník ◽  
J. Lichtenberg ◽  
H. Mostecký

2019 ◽  
Vol 5 ◽  
pp. 205520761988578
Author(s):  
Marco Rispoli ◽  
Fabio Perrotta ◽  
Salvatore Buono ◽  
Antonio Corcione

The assessment of patients likely to undergo lung resection surgery is a multidisciplinary approach involving pulmonologists, surgeons and anaesthesiologists. In thoracic surgery, medical operability is also a calculation of postoperative lung function. A mobile application – PreParAPP MSD – to calculate postoperative lung function has been developed with the endorsement of the Italian Society of Anaesthesia, Analgesia and Intensive Care and with the unconditional support of MSD Italia. Thanks to a simple graphic interface, the calculation becomes fast and intuitive, while the possibility of storing and sharing data in an analytical and computerised way with other clinicians might help with the full assessment of patients without forcing them to undergo several medical examinations. These simple calculated parameters are performed by a minority of clinicians, generally anaesthesiologists. In our facility, there is a team involved in the perioperative evaluation of lung resection surgery (13 pulmonologists, 9 surgeons and 5 anaesthesiologists). In order to evaluate the possible Awareness towards postoperative lung function calculation better, we organised an internal survey with 27 clinicians who are members of such a team before and after the introduction of the PreParAPP MSD. It was found that after the introduction of PreParAPP MSD, the percentage of clinicians involved in postoperative lung function calculation rose from 18% to 70%. The implementation of a digital tool may help to improve guideline adherence, in accordance with other experiences in which such tools represented the start for various quality improvement purposes throughout the medical field.


2017 ◽  
Vol 12 (1) ◽  
pp. S731-S732
Author(s):  
Yohei Yurugi ◽  
Yoshiteru Kidokoro ◽  
Takashi Ono ◽  
Yasuaki Kubouchi ◽  
Makoto Wakahara ◽  
...  

Respiration ◽  
1994 ◽  
Vol 61 (4) ◽  
pp. 181-186 ◽  
Author(s):  
C.T. Bolliger ◽  
M. Solèr ◽  
P. Stulz’ ◽  
E. Grädel ◽  
J. Müller-Brand ◽  
...  

2019 ◽  
Vol 56 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Nuria M Novoa ◽  
Pedro Esteban ◽  
Maria Teresa Gómez Hernández ◽  
Marta G Fuentes ◽  
Gonzalo Varela ◽  
...  

Abstract OBJECTIVES In healthy individuals, increasing pulmonary blood flow during exercise also increases the % of the diffusing capacity of the lungs for carbon monoxide (DLCO%), but its evolution after lung resection is unknown. In this study, our goal was to measure changes in exercise DLCO% during the first 3 days after anatomical lung resection. METHODS We performed a prospective observational study on consecutive patients with non-small-cell lung cancer scheduled for anatomical resection, except pneumonectomy, during a 6-month period. Patients underwent measurement of the DLCO% by a single-breath technique adjusted by the concentration of haemoglobin—before and after standardized exercise the day before and 3 consecutive days after surgery. The delta (Δ) variation (basal versus exercise) was calculated. The number of functioning resected segments was calculated by bronchoscopy. Postoperative pain and pleural air leak were estimated using a visual analogue scale and graduated conventional pleural drainage systems, respectively, and their influence on ΔDLCO each postoperative day was evaluated by linear regression analysis. RESULTS Fifty-seven patients were included. The visual analogue scale of pain and pleural air leaks were not correlated to Δ values (model R2: 0.0048). The evolution of Δ values during 3 postoperative days showed a progressive recovery of values, but on the third day, DLCO% capacity during exercise was still impaired (P < 0.01), especially in patients who underwent a resection of more than 3 functioning segments. CONCLUSIONS Physiological increase in DLCO% during exercise is still impaired on the third postoperative day in patients undergoing resection of more than 3 functioning pulmonary segments. This fact should be considered before discharging those patients after anatomical lung resection.


2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Salma Bibi Kadiri ◽  
Amy Pamela Kerr ◽  
Nicola Katy Oswald ◽  
Alina-Maria Budacan ◽  
Sarah Flanagan ◽  
...  

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