The Reticulo-Endothelial System and Immunological Phenomena

2015 ◽  
pp. 559-598 ◽  
Author(s):  
G. J. Thorbecke ◽  
B. Benacerraf
Keyword(s):  
Reticulo Endothelial System

Erythrophagocytosis in the Liver in Hemolytic Anemias

1968 ◽  
Vol 26 ◽  
pp. 184-185
Author(s):  
O. T. Minick ◽  
E. Orfei ◽  
F. Volini ◽  
G. Kent
Keyword(s):  
Acid Phosphatase ◽  
Oxidative Damage ◽  
Phosphatase Activity ◽  
Kupffer Cells ◽  
Acid Phosphatase Activity ◽  
Common Type ◽  
Red Cell ◽  
Cell Fragments ◽  
Reticulo Endothelial System ◽  
Important Site

Hemolytic anemias were produced in rats by administering phenylhydrazine or anti-erythrocytic (rooster) serum, the latter having agglutinin and hemolysin titers exceeding 1:1000.Following administration of phenylhydrazine, the erythrocytes undergo oxidative damage and are removed from the circulation by the cells of the reticulo-endothelial system, predominantly by the spleen. With increasing dosage or if animals are splenectomized, the Kupffer cells become an important site of sequestration and are greatly hypertrophied. Whole red cells are the most common type engulfed; they are broken down in digestive vacuoles, as shown by the presence of acid phosphatase activity (Fig. 1). Heinz body material and membranes persist longer than native hemoglobin. With larger doses of phenylhydrazine, erythrocytes undergo intravascular fragmentation, and the particles phagocytized are now mainly red cell fragments of varying sizes (Fig. 2).

scholarly journals Effect of Antibiotics on the Phagocytic Activity of the Reticulo-Endothelial System

Nature ◽  
1958 ◽  
Vol 181 (4624) ◽  
pp. 1662-1662 ◽  
Author(s):  
I. A. SEWELL ◽  
T. NICOL
Keyword(s):  
Phagocytic Activity ◽  
Reticulo Endothelial System

scholarly journals Labeling of Salmonella Typhymurium with iodine-131 to study phagocytic function in rats

1989 ◽  
Vol 31 (3) ◽  
pp. 135-138
Author(s):  
Maria K. Sato ◽  
Aldo J. Rodrigues Junior ◽  
Edwaldo E. Camargo
Keyword(s):  
Whole Body ◽  
Large Field ◽  
Scintillation Camera ◽  
Functional Evaluation ◽  
Body Images ◽  
System A ◽  
Carrier Free ◽  
Free Iodine ◽  
Iodine 131 ◽  
Reticulo Endothelial System

The present study describes a method for labeling Salmonella typhymurium with iodine-131 to evaluate both the morphological and the functional characteristics of the reticulo-endothelial system. A suspension containing 2 x 10(9) bacteria per ml was labeled with carrier-free Na131I without reductor, with a labeling yield of 46.5 ± 3% and 3.5 ± 1.3% of free Iodine-131. The biodistribution of the labeled bacteria in rats was studied with a large field-of-view scintillation camera equiped with a pinhole collimator. Whole body images were obtained 15 and 30 minutes after intravenous injection of the labeled microorganisms. Images showed accumulation of bacteria in the liver and both normal and transplanted spleens of the animals. Autoradiographs of liver and spleen demonstrated labeled bacteria within the cells of the reticulo-endothelial system. The method described is easy to perform, has a good labeling yield and allows the functional evaluation of the reticulo-monophagocytic system, including transplanted spleens.

EFFECTS OF A GLUCOCORTICOID (DEXAMETHASONE) ON THE EOSINOPHILS OF THE RAT

1967 ◽  
Vol 37 (4) ◽  
pp. 463-469 ◽  
Author(s):  
EVELYN C. BLENKINSOPP ◽  
W. K. BLENKINSOPP
Keyword(s):  
Continuous Infusion ◽  
Deoxyribonucleic Acid ◽  
Tritiated Thymidine ◽  
Blood Eosinophil ◽  
Consequent Reduction ◽  
Reticulo Endothelial System ◽  
Eosinophil Counts

SUMMARY The effects of single and continuous administrations of a synthetic gluco-corticoid (dexamethasone) on eosinophil numbers and distribution have been studied. Absolute blood eosinophil counts were made, and the turnover of the eosinophils was examined by continuous infusion of tritiated thymidine to label the deoxyribonucleic acid of all newly formed cells. Dexamethasone equivalent to less than 200 μg. cortisone/100 g. rat/day produced disappearance of eosinophils from the blood and the normal output of glucocorticoids is therefore probably less than this. Single administrations of dexamethasone produced a blood eosinopenia within 2 hr. due to removal and destruction of eosinophils by the reticulo-endothelial system. Continuous dexamethasone administration reduced the number of proliferating eosinophil cells in the marrow, with a consequent reduction in the number of eosinophils in the tissues.

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