Failure to Detect Australia Antigen in Correspondence to other Clinical, Epidemiological and Laboratory Data in Children with Infectious Hepatitis

2015 ◽  
pp. 318-319
Author(s):  
Brigitte Alvermann ◽  
K. Spies ◽  
J. P�Sghel ◽  
B. Schneeweiss
Keyword(s):  
Laboratory Data ◽  
Infectious Hepatitis ◽  
Australia Antigen

Failure to Detect Australia Antigen in Correspondence to other Clinical, Epidemiological and Laboratory Data in Children with Infectious Hepatitis

Vox Sanguinis ◽  
1970 ◽  
Vol 19 (3-4) ◽  
pp. 318-319
Author(s):  
Brigitte Alvermann ◽  
K. Spies ◽  
J. Püschel ◽  
B. Schneeweiss
Keyword(s):  
Laboratory Data ◽  
Infectious Hepatitis ◽  
Australia Antigen

scholarly journals THE LOCALIZATION OF AUSTRALIA ANTIGEN BY IMMUNOFLUORESCENCE

1970 ◽  
Vol 131 (2) ◽  
pp. 307-319 ◽  
Author(s):  
Veronica E. Coyne(Zavatone) ◽  
Irving Millman ◽  
James Cerda ◽  
B. J. S. Gerstley ◽  
Thomas London ◽  
...  
Keyword(s):  
Fluorescent Antibody ◽  
Liver Cells ◽  
Infectious Hepatitis ◽  
Buffy Coat ◽  
Fluorescent Antibody Technique ◽  
Australia Antigen ◽  
Antibody Technique ◽  
Biopsy Specimens ◽  
Lymphocyte Cultures ◽  
Fluorescent Particles

We have studied the localization of Australia antigen, a particulate substance associated with hepatitis, by means of the fluorescent antibody technique. Preparations were made from 61 liver biopsy specimens taken from patients with infectious hepatitis, serum hepatitis, and a variety of other diseases. When tested with fluorescein-conjugated rabbit anti-Au(1) antisera all 26 patients who had Au(1) in their serum had specific fluorescence in their liver cells. The fluorescence appeared in three forms: as discrete particles within the nucleus, diffuse fluorescence of the entire nucleus, and fluorescence of the nuclear rim. Occasionally there were also fluorescent particles in the cytoplasm. Other specimens were tested with the fluorescent antibody including a variety of human tissues, buffy coat smears, peripheral lymphocyte cultures, and cells obtained from bile and duodenal drainage. Among these specimens, fluorescence was found in the cytoplasm of a few cells in the bone marrow of two patients with hepatitis and Au(1) in their serum, and in the liver, spleen, mesentery, and testis of one patient with leukemia, chronic hepatitis, and Au(1) in his serum. We have shown that the presence of fluorescent particles in the liver cells is strongly associated with the presence of Au(1) in the serum and the diagnosis of viral hepatitis. We believe that this study adds support to the hypothesis that Australia antigen is an antigenic determinant of a virus capable of causing hepatitis.

Search for Ferris's Fecal Antigen and Australia Antigen in Stool Samples Obtained During a Large Outbreak of Infectious Hepatitis

1972 ◽  
Vol 139 (3) ◽  
pp. 1028-1031 ◽  
Author(s):  
D. L. Madden ◽  
E. B. Matthew ◽  
D. E. Dietzman ◽  
J. L. Sever ◽  
B. Nagler
Keyword(s):  
Infectious Hepatitis ◽  
Australia Antigen ◽  
Large Outbreak ◽  
Stool Samples

The occurrence of epidemic infectious hepatitis in chronic carriers of Australia antigen

1972 ◽  
Vol 80 (4) ◽  
pp. 577-582 ◽  
Author(s):  
Dale E. Dietzman ◽  
Earl B. Matthew ◽  
David L. Madden ◽  
John L. Sever ◽  
Michael Rostafinski ◽  
...  
Keyword(s):  
Infectious Hepatitis ◽  
Australia Antigen

scholarly journals Antibodies against adeno-, cytomegalo- and rubella viruses in Australia-antigen-negative sera from patients with infectious hepatitis

1974 ◽  
Vol 72 (3) ◽  
pp. 433-439 ◽  
Author(s):  
J. Alwen ◽  
A. M. Emmerson
Keyword(s):  
General Population ◽  
Rubella Virus ◽  
Adenovirus Type ◽  
Infectious Hepatitis ◽  
Australia Antigen ◽  
Adenovirus Type 5 ◽  
Virus Haemagglutinin

SUMMARYAntibodies neutralizing adenovirus type 5 were found in all of 50 pairs (100%) of sera from patients with acute icteric infectious hepatitis. The incidence in sera from the general population was 57%. No differences in mean titre or in proportion of positive sera were found in the same sera tested for complement-fixing antibodies to cytomegalovirus and for antibodies to rubella virus haemagglutinin. The results can be interpreted as supporting the involvement, either direct or indirect, of adenovirus in the aetiology of infectious hepatitis; but could also be due to a non-specific anamnestic enhancement of the production of antibody to adenovirus, or to coincidental infection with adenovirus and the agent of infectious hepatitis.

scholarly journals Screening for transmission of hepatitis within a liver unit

1972 ◽  
Vol 70 (1) ◽  
pp. 197-202 ◽  
Author(s):  
P. Bentley ◽  
D. Haynes ◽  
P. Sharpstone ◽  
P. E. Taylor ◽  
A. J. Zuckerman ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis Virus ◽  
Infectious Hepatitis ◽  
Australia Antigen ◽  
Staff Members ◽  
Plasma Bilirubin ◽  
Therapeutic Procedures ◽  
Serum Aspartate Aminotransferase ◽  
Persistent Elevation ◽  
Apparently Healthy

SUMMARYDetailed screening of the patients and staff in a unit specializing in liver disease was carried out over a year to ascertain whether transmission of the serum hepatitis virus was occurring and whether the situation was comparable in any way to that found in a Renal Haemodialysis Unit. Of the 154 patients with liver disease tested on admission, 6% were found to have Australia antigen in the serum and throughout the year there were rarely less than two patients in the ward at any one time with positive serum. No instances of clinical hepatitis were detected in the other patients following their stay in the ward or in their attendant medical, nursing and lay staff. Six staff members were found to have Australia antigen in their serum. In four of these, all nurses, it was present in the first sample tested and so the infection may have been acquired earlier. Temporary elevations in both plasma bilirubin and serum aspartate aminotransferase levels were found in another five staff members whose serum was negative for Australia antigen and who clinically were well. In a further eight and apparently healthy staff members, an isolated but persistent elevation of the plasma bilirubin was noted. In both groups these changes could represent the spread of subclinical infectious hepatitis and it is recommended that in units dealing with ‘liver patients’ not only should considerable care be taken during diagnostic and therapeutic procedures but the medical and nursing staff should be screened at regular intervals.

Elevations of Serum Transaminase Activities Following Infectious Hepatitis

1961 ◽  
Vol 41 (1) ◽  
pp. 9-15 ◽  
Author(s):  
James W. Mosley ◽  
H. Bruce Dull ◽  
Theodore C. Doege ◽  
Harold D. Kuykendall
Keyword(s):  
Infectious Hepatitis ◽  
Serum Transaminase

Infectious Hepatitis (Homologous Serum Type) in Drug Addicts

1950 ◽  
Vol 15 (4) ◽  
pp. 642-646 ◽  
Author(s):  
Frederick Steigmann ◽  
Samuel Hyman ◽  
Robert Goldbloom
Keyword(s):  
Infectious Hepatitis ◽  
Drug Addicts ◽  
Homologous Serum ◽  
Serum Type

Acth in the Treatment of Infectious Hepatitis

1955 ◽  
Vol 28 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Elmer C. Johnson ◽  
Hugh D. Bennett
Keyword(s):  
Infectious Hepatitis
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