Effects of Cortisone in Various Stages of Experimental Liver Injury

2015 ◽  
pp. 72-75
Author(s):  
E. Rubin ◽  
F. Hutterer
Keyword(s):  
Liver Injury ◽  
Experimental Liver

Effect of Dextran Sulfate on Experimental Liver Injury

Kanzo ◽  
1974 ◽  
Vol 15 (8) ◽  
pp. 463-471
Author(s):  
Setsuro FUJII ◽  
Hiromichi OKUDA
Keyword(s):  
Liver Injury ◽  
Dextran Sulfate ◽  
Experimental Liver

scholarly journals F-Antigen: Nature Liver Specificity, and Release in Experimental Liver Injury

1976 ◽  
Vol 71 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Yasuyuki Arakawa ◽  
David M. Bull ◽  
Chester F. Schott ◽  
Charles S. Davidson
Keyword(s):  
Liver Injury ◽  
Experimental Liver

scholarly journals Pharmacological Studies on Puerariae Flos. II. The Effects of Puerariae Flos on Alcohol-Induced Unusual Metabolism and Experimental Liver Injury in Mice

1990 ◽  
Vol 110 (8) ◽  
pp. 604-611 ◽  
Author(s):  
Yujiro NIIHO ◽  
Takashi YAMAZAKI ◽  
Yoshijiro NAKAJIMA ◽  
Hiroshi ITOH ◽  
Takashi TAKESHITA ◽  
...  
Keyword(s):  
Liver Injury ◽  
Pharmacological Studies ◽  
Experimental Liver ◽  
Puerariae Flos

scholarly journals Effect of Puerarin Regulated mTOR Signaling Pathway in Experimental Liver Injury

2018 ◽  
Vol 9 ◽  
Author(s):  
Bu-Gao Zhou ◽  
Hai-Mei Zhao ◽  
Xiu-Yun Lu ◽  
Wen Zhou ◽  
Fu-Chun Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Experimental Liver

scholarly journals Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

2010 ◽  
Vol 108 (1) ◽  
pp. 308-313 ◽  
Author(s):  
Christoph H. Österreicher ◽  
Melitta Penz-Österreicher ◽  
Sergei I. Grivennikov ◽  
Monica Guma ◽  
Ekaterina K. Koltsova ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Disease ◽  
Liver Injury ◽  
Specific Protein ◽  
Lineage Tracing ◽  
Genetic Lineage ◽  
Type I ◽  
Mesenchymal Transition ◽  
Specific Subset ◽  
Experimental Liver

Cirrhosis is the end result of chronic liver disease. Hepatic stellate cells (HSC) are believed to be the major source of collagen-producing myofibroblasts in cirrhotic livers. Portal fibroblasts, bone marrow-derived cells, and epithelial to mesenchymal transition (EMT) might also contribute to the myofibroblast population in damaged livers. Fibroblast-specific protein 1 (FSP1, also called S100A4) is considered a marker of fibroblasts in different organs undergoing tissue remodeling and is used to identify fibroblasts derived from EMT in several organs including the liver. The aim of this study was to characterize FSP1-positive cells in human and experimental liver disease. FSP1-positive cells were increased in human and mouse experimental liver injury including liver cancer. However, FSP1 was not expressed by HSC or type I collagen-producing fibroblasts. Likewise, FSP1-positive cells did not express classical myofibroblast markers, including αSMA and desmin, and were not myofibroblast precursors in injured livers as evaluated by genetic lineage tracing experiments. Surprisingly, FSP1-positive cells expressed F4/80 and other markers of the myeloid-monocytic lineage as evaluated by double immunofluorescence staining, cell fate tracking, flow cytometry, and transcriptional profiling. Similar results were obtained for bone marrow-derived and peritoneal macrophages. FSP1-positive cells were characterized by increased expression of COX2, osteopontin, inflammatory cytokines, and chemokines but reduced expression of MMP3 and TIMP3 compared with Kupffer cells/macrophages. These findings suggest that FSP1 is a marker of a specific subset of inflammatory macrophages in liver injury, fibrosis, and cancer.

Alterations of hepatic enzyme levels and of the acinar distribution of glutamine synthetase in response to experimental liver injury in the rat

Hepatology ◽  
1988 ◽  
Vol 8 (4) ◽  
pp. 822-830 ◽  
Author(s):  
Rolf Gebhardt ◽  
Hans-Jörg Burger ◽  
Hans Heini ◽  
Karl-Ludwig Schreiber ◽  
Dieter Mecke
Keyword(s):  
Liver Injury ◽  
Glutamine Synthetase ◽  
Hepatic Enzyme ◽  
Experimental Liver
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