Zollinger-Ellison Syndrome Associated with Solitary Aberrant Pancreatic Adenoma

Ulcerogenic Tumors of the Pancreas

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100676 ◽

1968 ◽

Vol 26 ◽

pp. 186-187

Author(s):

J. C. Garancis ◽

J. F. Kuzma ◽

S. D. Wilson ◽

E. H. Ellison

Keyword(s):

Endoplasmic Reticulum ◽

Tumor Cells ◽

Islet Cell ◽

Disease Process ◽

Central Core ◽

Islet Cell Tumors ◽

Opaque Zone ◽

Granular Form ◽

Zollinger Ellison Syndrome

It has been proposed that a gastrin-like hormone elaborated by non-beta islet tumors of the pancreas may be responsible for a fulminating ulcer diathesis. Subsequently, a potent gastric secretagogue was isolated from ulcerogenic tumors of the pancreas. This disease process is known now as “Zollinger-Ellison syndrome”.In our studies of two cases of Zollinger-Ellison syndrome, pancreatic lesions were identified as alpha islet cell tumors (Fig. 1). Tumor cells were fairly uniform. The sizes of the alpha granules were not significantly different, but their number and distribution varied greatly from one cell to another. Each granule consisted of a round, highly dense central core, separated from the limiting membrane by an opaque zone. The granular form of the endoplasmic reticulum was particularly prominent. Numerous mitochondria, round or elongated, were dispersed throughout the cytoplasm. Individual or clusters of lysosomes were observed in the majority of cells.

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Efficacious long-term maintenance therapy with pantoprazole (PAN) in patients with Zollinger-Ellison syndrome

Gastroenterology ◽

10.1016/s0016-5085(01)83051-1 ◽

2001 ◽

Vol 120 (5) ◽

pp. A613-A613

Author(s):

P BORNMAN ◽

K RADEBOLD ◽

H DEBAERE ◽

L VENTER ◽

H HEINZE ◽

...

Keyword(s):

Maintenance Therapy ◽

Zollinger Ellison Syndrome ◽

Term Maintenance

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Excluded Gastric Antrum Simulating the Zollinger-Ellison Syndrome

Gastroenterology ◽

10.1016/s0016-5085(19)34766-3 ◽

1964 ◽

Vol 47 (2) ◽

pp. 184-187 ◽

Cited By ~ 22

Author(s):

Brian A. Scobie ◽

Douglas B. McGill ◽

James T. Priestley ◽

Randolph A. Rovelstad

Keyword(s):

Gastric Antrum ◽

Zollinger Ellison Syndrome

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Zollinger-Ellison Syndrome

Gastroenterology ◽

10.1016/s0016-5085(63)80067-0 ◽

1963 ◽

Vol 44 (4) ◽

pp. 512-518 ◽

Cited By ~ 15

Author(s):

L. Angervall ◽

G. Dotevall ◽

K.-E. Lehmann ◽

P.B. Norberg

Keyword(s):

Zollinger Ellison Syndrome

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Zollinger-Ellison Syndrome: A Case Report

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1999.41.6.1173 ◽

1999 ◽

Vol 41 (6) ◽

pp. 1173 ◽

Cited By ~ 1

Author(s):

Dong Jin Jung ◽

Hyun Kwon Ha ◽

Pyo Nyun Kim ◽

Moon Gyu Lee ◽

Yong Ho Auh

Keyword(s):

Case Report ◽

Zollinger Ellison Syndrome

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Gastric Acid-Related Diseases: Focus on Esomeprazole

Clinical Medicine Insights Therapeutics ◽

10.4137/cmt.s4500 ◽

2010 ◽

Vol 2 ◽

pp. CMT.S4500

Author(s):

B. Al-Judaibi ◽

N. Chande ◽

G.K. Dresser ◽

N. Sultan ◽

J.C. Gregor

Keyword(s):

Duodenal Ulcer ◽

Helicobacter Pylori ◽

Symptom Relief ◽

Competitive Inhibitor ◽

Gastric Ph ◽

Disease Treatment ◽

Ulcer Disease ◽

Zollinger Ellison Syndrome ◽

Prevention And Treatment ◽

Inflammatory Drugs

Esomeprazole (S-omeprazole) is a single optical enantiomer proton-pump inhibitor (PPI) approved for the management of gastro-oesophageal reflux disease, the prevention and treatment of Non-Steroidal Anti-Inflammatory Drugs (NSAID) associated gastric ulcer disease, treatment of duodenal ulcer disease associated with Helicobacter pylori infection, and the treatment of Zollinger-Ellison syndrome. Esomeprazole has been shown to be safe and effective during pregnancy and was introduced to the market in 2001. PPI therapy may interact with clopidogrel by cytocrome 2C19. Clopidogrel is a prodrug which is partially activated by cytochrome 2C19 and esomeprazole is a competitive inhibitor of 2C19. Esomeprazole is more effective than other PPIs in controlling esophageal and gastric pH, but efficacy in symptom relief is less clear.

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