Electroretinography in the Diagnosis of Congenital Blindness

2015 ◽  
pp. 451-472
Author(s):  
J. Fran�ois ◽  
A. De Rouck
Keyword(s):  
2017 ◽  
Vol 3 (2) ◽  
pp. 1-2
Author(s):  
Reza Bidaki ◽  
Zahra Fazaelipour ◽  
Ehsan Zarepur ◽  
Amir Reza Chamani

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria J. S. Guerreiro ◽  
Madita Linke ◽  
Sunitha Lingareddy ◽  
Ramesh Kekunnaya ◽  
Brigitte Röder

AbstractLower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.


Neurocase ◽  
2014 ◽  
Vol 21 (6) ◽  
pp. 748-752
Author(s):  
Gianina Toller ◽  
Babu Adhimoolam ◽  
Thomas Grunwald ◽  
Hans-Jürgen Huppertz ◽  
Kristina König ◽  
...  

The Lancet ◽  
1844 ◽  
Vol 41 (1063) ◽  
pp. 514-516
Author(s):  
Franz

BMJ ◽  
1973 ◽  
Vol 1 (5853) ◽  
pp. 615-615
Author(s):  
D M Wills

2008 ◽  
Vol 187 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Maurice Ptito ◽  
Fabien C. G. Schneider ◽  
Olaf B. Paulson ◽  
Ron Kupers

2018 ◽  
Vol 202 ◽  
pp. 414-416 ◽  
Author(s):  
Vera A. Morgan ◽  
Melanie Clark ◽  
Julie Crewe ◽  
Giulietta Valuri ◽  
David A. Mackey ◽  
...  

2019 ◽  
Vol 30 (3) ◽  
pp. 1407-1421 ◽  
Author(s):  
Loïc Magrou ◽  
Pascal Barone ◽  
Nikola T Markov ◽  
Gwylan Scheeren ◽  
Herbert P Killackey ◽  
...  

Abstract There is an extensive modification of the functional organization of the brain in the congenital blind human, although there is little understanding of the structural underpinnings of these changes. The visual system of macaque has been extensively characterized both anatomically and functionally. We have taken advantage of this to examine the influence of congenital blindness in a macaque model of developmental anophthalmia. Developmental anophthalmia in macaque effectively removes the normal influence of the thalamus on cortical development leading to an induced “hybrid cortex (HC)” combining features of primary visual and extrastriate cortex. Here we show that retrograde tracers injected in early visual areas, including HC, reveal a drastic reduction of cortical projections of the reduced lateral geniculate nucleus. In addition, there is an important expansion of projections from the pulvinar complex to the HC, compared to the controls. These findings show that the functional consequences of congenital blindness need to be considered in terms of both modifications of the interareal cortical network and the ascending visual pathways.


2019 ◽  
Vol 30 (10) ◽  
pp. 1473-1482 ◽  
Author(s):  
Suddha Sourav ◽  
Ramesh Kekunnaya ◽  
Idris Shareef ◽  
Seema Banerjee ◽  
Davide Bottari ◽  
...  

Humans preferentially match arbitrary words containing higher- and lower-frequency phonemes to angular and smooth shapes, respectively. Here, we investigated the role of visual experience in the development of audiovisual and audiohaptic sound–shape associations (SSAs) using a unique set of five groups: individuals who had suffered a transient period of congenital blindness through congenital bilateral dense cataracts before undergoing cataract-reversal surgeries (CC group), individuals with a history of developmental cataracts (DC group), individuals with congenital permanent blindness (CB group), individuals with late permanent blindness (LB group), and controls with typical sight (TS group). Whereas the TS and LB groups showed highly robust SSAs, the CB, CC, and DC groups did not—in any of the modality combinations tested. These results provide evidence for a protracted sensitive period during which aberrant vision prevents SSA acquisition. Moreover, the finding of a systematic SSA in the LB group demonstrates that representations acquired during the sensitive period are resilient to loss despite dramatically changed experience.


Sign in / Sign up

Export Citation Format

Share Document