1. Value of Experimental Epilepsy Models for Clinical Research

2015 ◽  
pp. 1-13
Author(s):  
J. Majkowski
Keyword(s):  
Clinical Research ◽  
Experimental Epilepsy ◽  
Epilepsy Models

scholarly journals Effect of Gentiana olivieri on experimental epilepsy models

2011 ◽  
Vol 7 (28) ◽  
pp. 344 ◽  
Author(s):  
DidemDeliorman Orhan ◽  
Mustafa Aslan ◽  
Nilufer Orhan
Keyword(s):  
Experimental Epilepsy ◽  
Epilepsy Models

Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models

Neuroreport ◽  
1998 ◽  
Vol 9 (10) ◽  
pp. 2415-2421 ◽  
Author(s):  
M. C. Doretto ◽  
N. Garcia-Cairasco ◽  
N. J.G. Pimenta ◽  
D. A. Souza ◽  
M. A.K.F. Tatsuo
Keyword(s):  
Experimental Epilepsy ◽  
Anticonvulsant Agent ◽  
Epilepsy Models

INVESTIGATION OF THE THERAPEUTIC AND PROTECTIVE EFFECTS OF ATP SENSITIVE POTASSIUM CHANNEL (KATP) AGONISTS AND ANTAGONISTS ON PENICILLIN INDUCED EXPERIMENTAL EPILEPSY MODELS IN RATS

2021 ◽  
Vol 16 (3) ◽  
pp. 171-182
Author(s):  
Hayriye Soytürk ◽  
Şerif Demir ◽  
Ömer Bozdoğan
Keyword(s):  
Nervous System ◽  
Potassium Channel ◽  
Epileptiform Activity ◽  
The Other ◽  
Albino Rats ◽  
Experimental Epilepsy ◽  
Protective Effects ◽  
Epilepsy Models ◽  
Wistar Albino Rats

Epilepsy is a disease occurring because of extreme activation of nervous system. Increased glutamate and Ca++ in brain is another reason of epilepsy. In this study, we investigated the effects of ATP sensitive potassium channel (KATP) agonists and antagonists on penicillin induced epileptiform activity in male wistar albino rats. Rats were divided three experimental main groups; (1) Control, (2) Before seizures (BS) groups, (3) During seizure (DS) groups. DS and BS groups are divided into four subgroups; (a)5HD, (b)HMR1098, (c)Bepridil (d)P 1075. Bepridil and p1075, reduce the number of spike-waves, while the effect of Bepridil appears to have a similar effect when administered both during and before the seizure. HMR1098 and 5-HD both increased the seizures both when administered before or during the seizure, different from the other studies. When K ATP channel agonists are administered before and during the seizure, they reduce the seizures, while antagonists increase the seizure.

scholarly journals Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models

1997 ◽  
Vol 30 (8) ◽  
pp. 971-979 ◽  
Author(s):  
E.A. Del-Bel ◽  
P.R. Oliveira ◽  
J.A.C. Oliveira ◽  
P.K. Mishra ◽  
P.C. Jobe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Experimental Epilepsy ◽  
Epilepsy Models

Analytical Electron Microscopy (AEM) of Meningeal Cells Exposed to Particulate Cobalt During Studies of Experimental Epilepsy

1982 ◽  
Vol 40 ◽  
pp. 186-187
Author(s):  
R.G. Frederickson ◽  
R.G. Ulrich ◽  
J.L. Culberson
Keyword(s):  
Electron Microscopy ◽  
Analytical Electron Microscopy ◽  
Experimental Epilepsy ◽  
Metallic Cobalt ◽  
Experimental Animals ◽  
X Ray ◽  
Brain Surface ◽  
Meningeal Cells ◽  
Analytical Electron ◽  
The Brain

Metallic cobalt acts as an epileptogenic agent when placed on the brain surface of some experimental animals. The mechanism by which this substance produces abnormal neuronal discharge is unknown. One potentially useful approach to this problem is to study the cellular and extracellular distribution of elemental cobalt in the meninges and adjacent cerebral cortex. Since it is possible to demonstrate the morphological localization and distribution of heavy metals, such as cobalt, by correlative x-ray analysis and electron microscopy (i.e., by AEM), we are using AEM to locate and identify elemental cobalt in phagocytic meningeal cells of young 80-day postnatal opossums following a subdural injection of cobalt particles.

Another look at behavioral sciences in dentistry: perspectives on collaborative clinical research

1984 ◽  
Vol 48 (8) ◽  
pp. 448-452
Author(s):  
LA Tedesco ◽  
JE Albino ◽  
WM Feagans ◽  
RS Mackenzie
Keyword(s):  
Clinical Research ◽  
Behavioral Sciences

Clinical Research Updates 2000

2001 ◽  
Vol 11 (2) ◽  
pp. 9-11
Author(s):  
Madalena Walsh ◽  
Nan Bernstein Ratner
Keyword(s):  
Clinical Research
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