A Review of Variations in the Concentrations of Metabolites in the Blood of Beef and Dairy Cattle Associated with Physiology, Nutrition and Disease, with Particular Reference to the Interpretation of Metabolic Profiles

Use of metabolic profiles in dairy cattle in tropical and subtropical countries on smallholder dairy farms

Preventive Veterinary Medicine ◽

10.1016/s0167-5877(98)00118-4 ◽

1999 ◽

Vol 38 (2-3) ◽

pp. 119-131 ◽

Cited By ~ 27

Author(s):

D.A Whitaker ◽

W.J Goodger ◽

M Garcia ◽

B.M.A.O Perera ◽

F Wittwer

Keyword(s):

Dairy Cattle ◽

Dairy Farms ◽

Metabolic Profiles ◽

Smallholder Dairy ◽

Smallholder Dairy Farms

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A note on a possible association between plasma β-carotene levels and conception rate in a group of winter-housed dairy cattle

Animal Science ◽

10.1017/s0003356100024843 ◽

1981 ◽

Vol 32 (1) ◽

pp. 109-111 ◽

Cited By ~ 16

Author(s):

P. S. Jackson

Keyword(s):

Dairy Cattle ◽

Ovarian Function ◽

Poor Quality ◽

Metabolic Profiles ◽

Individual Animal ◽

Normal Range ◽

Blood Samples ◽

The Individual ◽

Β Carotene ◽

Friesian Cows

ABSTRACTThree groups of winter-housed Friesian cows were fed according to maintenance and production requirements on dairy cake and poor quality hay for 5 weeks (5 cows), 4 weeks (4 cows) or 2 weeks (3 cows). They were then treated as one group with two injections of 500 μg cloprostenol 11 days apart to synchronize oestrus, followed by insemination 72 and 96 h after the second treatment.Blood samples were taken for β-carotene estimation 1 day before the first cloprostenol injection, 3 days before the second injection, and the day after the second insemination. Conception was confirmed by rectal examination. Haematological parameters and metabolic profiles for all 12 cows were in the normal range and condition scores showed no correlation with time of conception. However, plasma β-carotene levels declined rapidly and uniformly between the three sample points for all cows. The individual animal means were directly correlated with length of time on the described diet and with time of conception (P<005). A theory of β-carotene involvement in ovarian function is advanced.

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Effects of Retinoic Acid and 1,25-Dihydroxyvitamin D3 on IFN-gamma Secretion by Mononuclear Leukocytes from Nulliparous and Postparturient Dairy Cattle

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.70.3.92 ◽

2000 ◽

Vol 70 (3) ◽

pp. 92-101 ◽

Cited By ~ 14

Author(s):

Burim Ametaj ◽

Brian Nonnecke ◽

Ronald Horst ◽

Donald Beitz

Keyword(s):

Retinoic Acid ◽

Dairy Cattle ◽

Dairy Cows ◽

Dairy Cow ◽

Pokeweed Mitogen ◽

Mononuclear Leukocytes ◽

Combined Effects ◽

Ifn Gamma ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D

Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. In the first experiment, effects on incubation period (24 to 72 hours) and time of supplementation (0 to 32 hours) with all-trans, 9-cis, 13-cis-, and 9,13-dicis-RAs (0 to 100 nM) on IFN-gamma secretion by pokeweed mitogen (PWM)-stimulated (0 and 10 mug/ml) MNL from nulliparous cattle were evaluated. In the second experiment, MNL from postparturient cows (bled at 0, 2, 4, and 16 days postpartum) were stimulated with PWM (0 and 10 mug/ml) in the presence of RA isomers (9-cis- or 9,13-dicis-RA; 0 to 100 nM), 1,25-(OH)2D3 (0 to 100 nM), or with combinations of these metabolites. The results show that individual isomers of RA had no effect on IFN-gamma secretion by PWM-stimulated MNL from nulliparous or postparturient cows. Furthermore 1,25-dihydroxyvitamin D3 inhibited IFN-gamma secretion by MNL from nulliparous and postparturient dairy cows; however, the degree of inhibition was greater when 9-cis- and 9,13-dicis-RA were also present in the cultures. Finally mononuclear leukocytes from postparturient dairy cows produced substantially less IFN-gamma than did MNL from nulliparous cattle. It is concluded that retinoic acids individually did not affect the capacity of leukocytes from dairy cattle to secrete IFN-gamma. This result is in marked contrast to studies in monogastric species indicating that RAs inhibit IFN-gamma secretion by peripheral blood T cells. Inhibition of IFN-gamma secretion by 1,25-(OH)2D3 was potentiated by 9-cis- and 9,13-di-cis-retinoics acids, suggesting that an excess of dietary vitamins A and D may compromise further the naturally immunosuppressed postparturient dairy cow. Additional research is necessary to determine if the combined effects of these metabolites on IFN-gamma secretion represent an increased susceptibility of the dairy cow to infectious diseases during the periparturient period. Lower secretion of IFN-gamma by MNL from postpartutient dairy cows, relative to nulliparous cattle, suggests that recently-calved cows are naturally immunosuppressed.

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