Ozone Toxicity Studies; Destruction of Alveolar Septa�a Precursor of Emphysema?

Ozone Toxicity Studies; Destruction of Alveolar Septa – a Precursor of Emphysema?

Respiration ◽

10.1159/000192426 ◽

1965 ◽

Vol 22 (3) ◽

pp. 376-381

Author(s):

P. Gross ◽

L.D. Scheel ◽

H.E. Stokinger

Keyword(s):

Toxicity Studies ◽

Ozone Toxicity ◽

Alveolar Septa

Download Full-text

Effects of Hyperoxia on Lung Utrastructure

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100067121 ◽

1970 ◽

Vol 28 ◽

pp. 26-27

Author(s):

Gladys Harrison

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Light Microscopy ◽

Oxygen Effects ◽

Age Dependent ◽

The Central Nervous System ◽

The Subject ◽

Space Age ◽

Alveolar Septa ◽

Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

Download Full-text

Preclinical Toxicity Studies of Naltrexone

PsycEXTRA Dataset ◽

10.1037/e497452006-006 ◽

1976 ◽

Cited By ~ 2

Author(s):

Monique C. Braude ◽

J. Michael Morrison

Keyword(s):

Toxicity Studies

Download Full-text

Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1269553 ◽

2011 ◽

Vol 49 (01) ◽

Author(s):

SA Hoffmann ◽

M Lübberstedt ◽

U Müller-Vieira ◽

D Knobeloch ◽

A Nüssler ◽

...

Keyword(s):

Liver Cell ◽

Human Liver ◽

In Vitro Toxicity ◽

Cell Cultivation ◽

Toxicity Studies ◽

Human Liver Cell ◽

Bioreactor System

Download Full-text

Acute and chronic toxicity studies on Polygonum glabrum in experimental animals

International Journal of Pharmacometrics and Integrated Biosciences ◽

10.26452/ijpib.v3i1.1216 ◽

2020 ◽

Vol 3 (1) ◽

pp. 7-10

Author(s):

Saravanakumar A ◽

Gandhimathi R

Keyword(s):

Chronic Toxicity ◽

Clinical Stage ◽

Herbal Medicines ◽

Plant Roots ◽

Root Extract ◽

Experimental Animals ◽

Toxicity Studies ◽

Acute And Chronic Toxicity ◽

Diuretic Agents

Polygonum glabrum is being used in traditional and folklore medicine to treat pneumonia and jaundice. Plant roots are used in ayurvedic preparations to treat fever and colic. The leaves are used as diuretic agents and process vermifuge action. Plant decoction is also used in the treatment of Rheumatism. Besides having many uses and folklore claims, herbal medicines are to be thoroughly investigated for their toxicity also. Therefore this work is being carried out to examine the toxicity of the drug and established dose is safe to use in the clinical stage. The current research studied the acute and chronic toxicity of Polygonum glabrum root extract in rats. It is proved that there was no change in any parameter tested both in acute and chronic toxicity, which means the extract is safe and non-toxic at the dose of 2g/kg also.

Download Full-text