Thymic Function and Carcinogenesis

2015 ◽  
pp. 165-191 ◽  
Author(s):  
R. C. Ting ◽  
L. W. Law
Keyword(s):  
Thymic Function

Recapitulation of Thymic Function by Tissue Engineering Strategies

2021 ◽  
pp. 2100773
Author(s):  
Catarina S. Silva ◽  
Rui L. Reis ◽  
Albino Martins ◽  
Nuno M. Neves
Keyword(s):  
Tissue Engineering ◽  
Thymic Function

scholarly journals Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts

2015 ◽  
Vol 23 (7) ◽  
pp. 1262-1277 ◽  
Author(s):  
Yong Fan ◽  
Asako Tajima ◽  
Saik Kia Goh ◽  
Xuehui Geng ◽  
Giulio Gualtierotti ◽  
...  
Keyword(s):  
Immune Tolerance ◽  
Thymic Function

scholarly journals Thymic function in the regulation of T cells, and molecular mechanisms underlying the modulation of cytokines and stress signaling

2017 ◽  
Vol 16 (5) ◽  
pp. 7175-7184 ◽  
Author(s):  
Fenggen Yan ◽  
Xiumei Mo ◽  
Junfeng Liu ◽  
Siqi Ye ◽  
Xing Zeng ◽  
...  
Keyword(s):  
T Cells ◽  
Molecular Mechanisms ◽  
Stress Signaling ◽  
Thymic Function

Thymic Function, Aging, and AIDS

1999 ◽  
Vol 34 (3) ◽  
pp. 59-88 ◽  
Author(s):  
Barton F. Haynes ◽  
Laura P. Hale
Keyword(s):  
Thymic Function

scholarly journals In Utero Arsenic Exposure Is Associated With Impaired Thymic Function in Newborns Possibly Via Oxidative Stress and Apoptosis

2012 ◽  
Vol 129 (2) ◽  
pp. 305-314 ◽  
Author(s):  
S. Ahmed ◽  
K. B. Ahsan ◽  
M. Kippler ◽  
A. Mily ◽  
Y. Wagatsuma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Arsenic Exposure ◽  
In Utero ◽  
Thymic Function

scholarly journals Dynamic structural cell responses in the thymus to acute injury, regeneration, and age

2021 ◽  
Author(s):  
Lorenz L Jahn ◽  
Anastasia I Kousa ◽  
Lisa Sikkema ◽  
Angel E Flores ◽  
Kimon V Argyropoulos ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Marrow Transplant ◽  
Cell Development ◽  
Acute Injury ◽  
Thymic Function ◽  
Structural Cell ◽  
Cell Responses ◽  
And Function ◽  
Old Mice

The thymus, the primary site of T cell development, is extremely sensitive to insult but also harbors tremendous capacity for repair. Using single cell sequencing of thymic structural cells, as well as functional and structural analyses, we revealed distinct regenerative programs by endothelial and mesenchymal subsets after injury that stimulated epithelial repair; the compartment primarily supporting T cell development. Thymic function not only declined over lifespan, contributing to immune aging, but the capacity of the thymus to regenerate after damage also declined in old mice. This could be attributed to an inability of the old microenvironment to induce reparative programs; leading to reduced ability to restore tissue structure and function. These findings provide a detailed framework for the response of structural cells to aging and acute damage, which could have considerable implications for our understanding of aging immunity and recovery from treatments such as chemotherapy and bone marrow transplant.

scholarly journals Functional Reconstitution of Thymopoiesis after Human Immunodeficiency Virus Infection

2000 ◽  
Vol 74 (6) ◽  
pp. 2943-2948 ◽  
Author(s):  
Scott G. Kitchen ◽  
Scott Killian ◽  
Janis V. Giorgi ◽  
Jerome A. Zack
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Treatment ◽  
Gene Families ◽  
Cell Receptor ◽  
Combination Antiretroviral Therapy ◽  
Thymic Function ◽  
Immunodeficiency Virus ◽  
Variable Gene ◽  
Costimulatory Signals

ABSTRACT We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4+ thymocyte depletion in the SCID-hu mouse to examine the immune competence of reconstituting thymocytes which appear following administration of combination therapy. These cells express a normal distribution of T-cell receptor variable gene families and are responsive to costimulatory signals. These results suggest that normal thymic function may be restored following antiretroviral treatment.

Characterizing Differences in Thymic Function in Women With and Without Vulvodynia: A Community-Based Study

2021 ◽  
Vol 25 (4) ◽  
pp. 296-302
Author(s):  
Sydney K. Willis ◽  
Allison E. Aiello ◽  
Devavani Chatterjea ◽  
Julie A. Nelson ◽  
Patricia L. Hibberd ◽  
...  
Keyword(s):  
Community Based ◽  
Thymic Function

Estimating Thymic Function Through Quantification of T-Cell Receptor Excision Circles

2007 ◽  
pp. 197-214
Author(s):  
Marie-Lise Dion ◽  
Rafick-Pierre Sékaly ◽  
Rémi Cheynier
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Thymic Function ◽  
Excision Circles

OR29 Establishment of an assay to assess the thymic function recovery and B-cell neogenesis for allogenic haematopoetic stem cell transplant recipients

2019 ◽  
Vol 80 ◽  
pp. 37
Author(s):  
Jenny Chung-Yee Ho ◽  
Ivan Wing-Hong Tang ◽  
Stephen Kwok-Fan Cheung ◽  
Patrick Wai-Keung Chu ◽  
Winnie Lai-Chu Tsang ◽  
...  
Keyword(s):  
Stem Cell ◽  
B Cell ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Transplant Recipients ◽  
Thymic Function ◽  
Function Recovery
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