The Internal Milieu of Tumors

Curt Richter made seminal contributions to our understanding of a number of issues regarding the relationships between physiology and behavior. He was the first to conceptualize behavior as an aspect of regulatory physiology. These ideas developed from his work on behavioral responses to a variety of physiological perturbations. The classic example is Richter's demonstration of the development of avid sodium ingestion in response to urinary sodium loss after adrenalectomy. Some of Richter's ideas on the nature and underlying physiology of specific appetites maintain their influence and continue to stimulate active investigation. Others, focused on abilities to self-select balanced diets, have not borne the test of time or experimental challenge. As current research takes a more molecular focus, Richter's ideas on behavior in the service of the internal milieu maintain their currency, and the search for the molecular bases for these relationships should serve as a research focus.

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Effects of dietary inclusion of Rhus coriaria on internal milieu of rabbits

Journal of Animal Physiology and Animal Nutrition ◽

10.1111/j.1439-0396.2011.01164.x ◽

2011 ◽

Vol 96 (3) ◽

pp. 459-465 ◽

Cited By ~ 12

Author(s):

M. Capcarova ◽

J. Slamecka ◽

K. Abbas ◽

A. Kolesarova ◽

A. Kalafova ◽

...

Keyword(s):

Internal Milieu ◽

Rhus Coriaria

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Psychosomatic disorder in phlebology

Phlebologie ◽

10.12687/phleb2235-6-2014 ◽

2014 ◽

Vol 43 (06) ◽

pp. 321-324

Author(s):

F. Amsler ◽

W. Blättler

Keyword(s):

Population Based ◽

Physiological Change ◽

Venous Disease ◽

Psychosomatic Disorder ◽

Unpleasant Sensation ◽

Internal Milieu ◽

The Individual ◽

Work Up ◽

Individual Importance ◽

The Brain

SummaryAccording to population-based studies, the prevalence of feelings of heaviness, swelling and pain in the legs is around 50 %. These feelings are often not accompanied by clinically detectable changes, but are the inevitable and generally unrecognised consequences of the increase in leg volume caused by standing still. We assume that the physiological change is detected as part of the constant information about the internal milieu that is sent to the corresponding centres in the brain. This information is modified by many factors, including emotion and – depending on the situation – is either appropriately perceived as an unpleasant sensation of swelling or not even noticed. These feelings can result in an impairment of vitality and depression. In some cases, a thorough phlebological work-up can reveal an occult organic venous disease, so that the feelings can be traced to a somatic cause. Feelings have a psychological and a somatic component; they are not imaginary. It is up to the doctor to discern the individual importance of the two components and to draw the appropriate conclusions regarding treatment.

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Inflammatory Cytokines in Nonpathological States

Physiology ◽

10.1152/physiologyonline.2000.15.6.298 ◽

2000 ◽

Vol 15 (6) ◽

pp. 298-303 ◽

Cited By ~ 11

Author(s):

Joseph G. Cannon

Keyword(s):

Inflammatory Cytokines ◽

Environmental Stressors ◽

Hostile Environment ◽

Internal Milieu ◽

Physiological Processes

During infection, inflammatory cytokines induce regulated changes in the host's internal milieu that create a hostile environment to an invading pathogen. Recent evidence indicates that these cytokines are constitutively produced, their production is increased by environmental stressors other than microbes, and they modulate “normal” physiological processes.

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