Plasma Levels of Vitamin D Metabolites in Renal Diseases1

2015 ◽  
pp. 18-27 ◽  
Author(s):  
Yosuke Ogura ◽  
Yoshindo Kawaguchi ◽  
Soichi Sakai ◽  
Masaru Yamamoto ◽  
Yasuo Kimura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Vitamin D Metabolites

scholarly journals Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2271 ◽  
Author(s):  
Jennifer Gjerde ◽  
Marian Kjellevold ◽  
Lisbeth Dahl ◽  
Torill Berg ◽  
Annbjørg Bøkevoll ◽  
...  
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Maternal Plasma ◽  
Vitamin D Metabolites ◽  
Endocrine Society ◽  
Liquid Chromatography Tandem Mass ◽  
Automated Sample Preparation ◽  
25 Oh Vitamin D ◽  
Accurate Quantification

Vitamin D deficiency in pregnant women and their offspring may result in unfavorable health outcomes for both mother and infant. A 25hydroxyvitamin D (25(OH)D) level of at least 75 nmol/L is recommended by the Endocrine Society. Validated, automated sample preparation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to determine the vitamin D metabolites status in mother-infant pairs. Detection of 3-Epi25(OH)D3 prevented overestimation of 25(OH)D3 and misclassification of vitamin D status. Sixty-three percent of maternal 25(OH)D plasma levels were less than the recommended level of 25(OH)D at 3 months. Additionally, breastmilk levels of 25(OH)D decreased from 60.1 nmol/L to 50.0 nmol/L between six weeks and three months (p < 0.01). Furthermore, there was a positive correlation between mother and infant plasma levels (p < 0.01, r = 0.56) at 3 months. Accordingly, 31% of the infants were categorized as vitamin D deficient (25(OH)D < 50 nmol/L) compared to 25% if 3-Epi25(OH)D3 was not distinguished from 25(OH)D3. This study highlights the importance of accurate quantification of 25(OH)D. Monitoring vitamin D metabolites in infant, maternal plasma, and breastmilk may be needed to ensure adequate levels in both mother and infant in the first 6 months of infant life.

Perinatal parathyroid hormone, vitamin D metabolites, and calcitonin in man

1980 ◽  
Vol 239 (5) ◽  
pp. E385-E390 ◽  
Author(s):  
P. Wieland ◽  
J. A. Fischer ◽  
U. Trechsel ◽  
H. R. Roth ◽  
K. Vetter ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Plasma Levels ◽  
Maternal Blood ◽  
Sign Test ◽  
Blood Levels ◽  
Vitamin D Metabolites ◽  
Dihydroxyvitamin D ◽  
Umbilical Blood ◽  
Arteriovenous Difference

Plasma levels of calcium and of parathyroid hormone (PTH) were comparable in the mothers at delivery and in nonpregnant controls; magnesium was decreased (P < 0.001) in maternal blood; and phosphate (P < 0.001), 1,25-dihydroxyvitamin D (1,25(OH)2D) (P < 0.001), and calcitonin (CT) (P < 0.01) were raised. Cord levels of calcium (P < 0.01), magnesium (P < 0.05), and CT (P < 0.01) were higher, and PTH (P < 0.01) was lower than in the maternal blood. Levels of 25(OH)D, 1,25(OH)2D, and 24,25(OH)2D lower in fetal than in maternal blood (P < 0.01) and significant linear correlations between the vitamin D metabolites examined in mothers and neonates (P < 0.001) are consistent with a diffusion barrier across the placenta and/or different affinities of binding proteins. Plasma levels of 25(OH)D and 24,25(OH)2D were significantly related (P < 0.01), suggesting precursor product type, relationships. Levels of 1,25(OH)2D higher in arterial than in venous umbilical blood (P = 0.06, sign test; P < 0.005, paired t test) suggest that the fetus participates in the synthesis of 1,25(OH)2D. Maternal PTH was significantly related to the arteriovenous difference of 1,25(OH)2D levels (P < 0.01) in cord blood, and it possibly enhances the synthesis of 1,25(OH)2D during the final stage of fetal development.

Plasma Levels of Vitamin D Metabolites in Diphosphonatetreated Rats

1981 ◽  
Vol 61 (4) ◽  
pp. 471-476 ◽  
Author(s):  
U. Trechsel ◽  
C. M. Taylor ◽  
J. A. Eisman ◽  
J.-P. Bonjour ◽  
H. Fleisch
Keyword(s):  
Vitamin D ◽  
Plasma Level ◽  
Protein Binding ◽  
Vitamin D3 ◽  
Plasma Levels ◽  
Precursor Concentration ◽  
Vitamin D Metabolites ◽  
Binding Assays ◽  
25 Hydroxy Vitamin D ◽  
Normal Laboratory

1. Protein-binding assays have been used to measure plasma 1,25-dihydroxy-vitamin D [1,25-(OH)2D] as well as 25-hydroxy-vitamin D [25-(OH)D] in rats given 10 mg of phosphorus (P) day−1 kg−1 as ethane-1-hydroxy-1,1-diphosphonate (EHDP). 2. In control animals given a normal laboratory chow plasma 25-(OH)D and 1,25-(OH)2D were about 40 nmol/l and 300 pmol/l respectively. 3. EHDP produced a decrease of plasma 1,25-(OH)2D to below 50 pmol/l in 2 days. 4. Both in control and in EHDP-treated rats plasma 1,25-(OH)2D increased when dietary calcium (Ca) was restricted to 0.1%, or dietary P to 0.2%, indicating that the well-known stimulatory effect of Ca or P deprivation was at least partially effective in EHDP-treated rats. 5. In response to an increase of the oral supply of vitamin D3 to 65 nmol/day the plasma level of 25-(OH)D rose in both control and EHDP groups. Plasma 1,25-(OH)2D was not increased above the normal value in control rats. In EHDP-treated rats, however, plasma 1,25-(OH)2D rose to a level equal to that in controls, suggesting that the effect of EHDP on plasma 1,25-(OH)2D can be overcome at high precursor concentration.

scholarly journals Plasma levels of vitamin D metabolites in the bovine species during the perinatal period

1981 ◽  
Vol 21 (1) ◽  
pp. 127-134 ◽  
Author(s):  
J. P. BARLET ◽  
T. Minh NGUYEN ◽  
Marie-Jeanne DAVICCO ◽  
C. DARDILLAT ◽  
J. LEFAIVRE ◽  
...  
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Perinatal Period ◽  
Vitamin D Metabolites ◽  
Bovine Species

Plasma Levels of Vitamin D Metabolites in Fetal and Pregnant Ewes

1987 ◽  
Vol 185 (3) ◽  
pp. 267-271 ◽  
Author(s):  
S. K. Paulson ◽  
H. F. DeLuca ◽  
F. Battaglia
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Vitamin D Metabolites

2223-PUB: Association of Vitamin D Metabolites with Type 2 Diabetes Complications in Qatar

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2223-PUB
Author(s):  
STEPHEN ATKIN ◽  
ALEXANDRA E. BUTLER
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetes Complications ◽  
Vitamin D Metabolites

Vitamin D metabolites in diabetic patients: Decreased serum concentration of 24,25-dihydroxyvitamin D

1982 ◽  
Vol 42 (6) ◽  
pp. 487-491 ◽  
Author(s):  
Claus Christiansen ◽  
Merete Sanvig Christensen ◽  
Peter McNair ◽  
Britta Nielsen ◽  
Steen Madsbad
Keyword(s):  
Vitamin D ◽  
Serum Concentration ◽  
Diabetic Patients ◽  
Vitamin D Metabolites ◽  
Dihydroxyvitamin D
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