Chapter IV Noninflammatory Glomerular Lesions in Proteinuria and the Nephrotic Syndrome

2015 ◽  
pp. 46-69
Keyword(s):  
Nephrotic Syndrome ◽  
Glomerular Lesions

AN UNUSUAL CASE OF NEW ONSET NEPHROPATHY IN A PATIENT OF PSORIASIS: CASE REPORT AND REVIEW OF LITERATURE

2021 ◽  
pp. 13-14
Author(s):  
VPS Punia ◽  
Apoorva Shetty ◽  
Prashant Prashant ◽  
Akash Bharti ◽  
Praveen Raman Mishra ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Case Report ◽  
Male Patient ◽  
Renal Damage ◽  
Unusual Case ◽  
Review Of Literature ◽  
Immune Mediated ◽  
Different Types ◽  
Glomerular Lesions ◽  
New Onset

Psoriasis is known to cause chronic inammatory disorder of the skin through an immune mediated mechanism, it may be complicated by different types of glomerular lesions. Three different mechanisms have been implicated by which psoriasis can cause renal damage: immune-mediated renal damage, drug-related renal damage and chronic renal damage. This report presents a case of 35 years old male patient with extensive psoriasis, who presented to our hospital with nephrotic syndrome

Urinary N-acetyl-beta-D-glucosaminidase isoenzyme activity as measured by fast protein liquid chromatography in patients with nephrotic syndrome

1990 ◽  
Vol 36 (1) ◽  
pp. 102-103 ◽  
Author(s):  
T Shibasaki ◽  
H Gomi ◽  
F Ishimoto ◽  
T Miyahara
Keyword(s):  
Nephrotic Syndrome ◽  
Liquid Chromatography ◽  
Column Chromatography ◽  
Healthy Subjects ◽  
Deae Cellulose ◽  
Proximal Tubules ◽  
Fast Protein Liquid Chromatography ◽  
Healthy Controls ◽  
Glomerular Lesions

Abstract Exactly why N-acetyl-beta-D-glucosaminidase (NAG) excretion is increased in patients with nephrotic syndrome with glomerular lesions is poorly understood. Glomeruli contain less NAG than do proximal tubules. In this study, we have tried to measure the NAG isoenzymes automatically by use of the recently developed fast protein liquid chromatography (FPLC) system, followed by column chromatography on DEAE cellulose (Mono Q). Three isoenzyme peaks--B, I + II, and A--were observed for urine from both healthy subjects and nephrotic patients. The B isoenzyme usually constituted about 10% of the total NAG in healthy controls, 30% in nephrotic patients. In contrast, the proportion of the A isoenzyme was inversely related to that of the B isoenzyme when healthy controls and nephrotic patients were compared. Our system for measuring NAG isoenzymes is reproducible and fast, and it should be useful in further studies.

Treatment of Experimental Nephrotic Syndrome with Artesunate

2007 ◽  
Vol 26 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Alireza Razavi ◽  
Hamid R. Nouri ◽  
Farhad Mehrabian ◽  
Abbas Mirshafiey
Keyword(s):  
Nephrotic Syndrome ◽  
Experimental Model ◽  
Mononuclear Cells ◽  
Serum Triglyceride ◽  
Treated Group ◽  
Lipid Lowering ◽  
Urine Sodium ◽  
Therapeutic Protocol ◽  
Glomerular Lesions ◽  
Lowering Drug

The present study was designed to test the therapeutic effect of a new antimalarial drug, artesunate in experimental model of nephrotic syndrome. To induce this experimental model, Adriamycin was given once by a single intravenous injection (7.5 mg/kg) through the tail vein. Six days after injection of Adriamycin, therapeutic protocol was developed by intraperitoneally (IP) administration of 5 mg/kg artesunate (ARS). Total of IP injections were 14, of which 5 injections were made every day and 9 injections were carried out at regular 48-h intervals. Therapeutic protocol was terminated on day 28 and animals were killed on day 49. The results showed that treatment with ARS caused a significant reduction in the level of proteinuria, urine urea and urine sodium compared with nontreated controls. In addition, decrease in serum triglyceride and increase in the level of serum albumin was significant in treated group with ARS compared with nontreated controls. Moreover, treatment with ARS significantly reduced glomerular polymorphonuclear (PMN) and mononuclear cells infiltration, hypercellularity, karyorrhexis, wire loops, and hydropic change in capillary network within the renal cortex, as well as decreased hyalin casts. On the other hand, healthy controls receiving ARS showed a significant decrease in amounts of serum triglyceride, urine urea, and urine sodium and potassium compared with normal group. These data suggest that artesunate therapy can ameliorate proteinuria, and suppress the progression of glomerular lesions in experimental model of nephrotic syndrome; it may also be recommended as a lipid-lowering drug.

scholarly journals Lupic Nephropathy: Our experience at the Department of Nephrology

2019 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Kidney Damage ◽  
Renal Diseases ◽  
Common Disease ◽  
Systemic Lupus ◽  
Glomerular Lesions ◽  
Glomerular Damage

Systemic lupus erythematosus (SLE) is the most common disease systemic autoimmune disorders that cause kidney damage. AT Conversely, kidney damage is the most common and the most severe visceral involvement of SLE. The most frequent renal involvement is glomerular and there are several types of glomerulonephritis (GN) Lupus now evaluated according to classification histological ISN / RPS (International Society of Nephrology/Renal Pathology Society) [1]. Other glomerular disorders such as a Nephrotic syndrome with minimal glomerular lesions are possible but rare. Vascular or interstitial lesions related to lupus may be associated with glomerular damage; they are rarely isolated. Finally, lupus nephropathy is sometimes mixed with renal diseases associated with lupus, the most common being renal antiphospholipid Syndrome.

P0465NEPHROTIC SYNDROME IN ELDERLY PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Tasnim Ben ayed ◽  
Imen Gorsane ◽  
Raja Trabelsi ◽  
Mondher Ounissi ◽  
Taieb Ben Abdallah
Keyword(s):  
Nephrotic Syndrome ◽  
Membranous Nephropathy ◽  
Immunosuppressive Treatment ◽  
Treatment Strategies ◽  
The Elderly ◽  
Albumin Level ◽  
Study Objective ◽  
Multicentric Study ◽  
Glomerular Lesions ◽  
The Mean

Abstract Background and Aims Nephrotic syndrome (NS) is one of the manifestations of acute or chronic glomerular nephropathy in the elderly. Our study objective was to determine the particularities of NS in the elderly. Method This is a retrospective study, carried out in the Internal Medicine department A of Charles Nicolle hospital at Tunis, between January the 1st, 1975 and December the 31st, 2016. This study included subjects aged 65 years old or over hospitalized for NS. Results We studied 115 patients with an average age of 71 ± 5 years [65-83 years] with a sex ratio (M/F) of 1.7. Twenty-three percent of patients were diabetic. The median proteinuria was 4.7 g/l [3-19.5 g/l], the mean albumin level was 20 ± 6g/l and the mean protidemia was 50.6 ± 6.9 g/l. Nephrotic syndrome was impure in 89.5 % of patients with high blood pressure in 54 % of cases, hematuria ≥2 + in 30% of cases and renal failure in 82.7 % of cases. Renal biopsy was performed in 45 patients. The most common glomerular lesions were Membranous nephropathy (29 %) followed by amyloidosis (24.5 %). NS was secondary in 65.2 % of cases mainly to amyloidosis (35.6 %) and diabetes (19 %). Idiopathic nephropaty was dominated by membranous nephropathy (9.5 %) and primitive primitive (MPGN) (4.3 %). The treatment was symptomatic for 84.4% of patients. Corticosteroids and/or immunosuppressive treatment have been used for 15.6% of patients. At the end of follow-up, 35.3 % of patients achieved complete or partial remission and 56.6 % progressed to ESRD. Conclusion Elderly NS was characterized by a poor prognosis due to delayed cosultation and non-uniform treatment strategies. Multicentric study in order to identify different action axes could improve the prognosis of this disease. Multicentric study in order to identify different action axes could improve the prognosis of this disease.

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