Chapter II Circulatory and Noninflammatory Vascular Disorders

2015 ◽  
pp. 22-34
Keyword(s):  
Vascular Disorders

Von Willebrand Factor Propeptide in Vascular Disorders

2001 ◽  
Vol 86 (07) ◽  
pp. 164-171 ◽  
Author(s):  
Thalia Romani de Wit ◽  
Jan van Mourik
Keyword(s):  
Vascular Disease ◽  
Von Willebrand Factor ◽  
Time Course ◽  
Cell Activation ◽  
Cellular Adhesion ◽  
Endothelial Cell Activation ◽  
Diagnostic Significance ◽  
Vascular Disorders ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryVon Willebrand factor (VWF) is a multifunctional plasma protein that plays a prominent role in haemostasis. In endothelial cells, processing of its precursor pro-VWF results in the formation of two large polypeptides, mature VWF and a propeptide. These proteins are co-secreted on an equimolar basis but are cleared from the circulation at different rates. VWF levels are frequently elevated in response to vascular disorders. Similarly, propeptide levels are increased under these conditions, although primarily in fulminant vascular disease, such as thrombotic thrombocytopenic purpura and septicemia. In chronic vascular disease, e.g. diabetes or peripheral vascular disease, propeptide levels are much less elevated. The differential response of VWF and propeptide levels to vascular disease could provide a means to assess the extent and time course of endothelial cell activation. After secretion, the propeptide may play a role in modulating cellular adhesion processes. Thus, enhanced propeptide secretion seems not to be of merely diagnostic significance.

scholarly journals Treatment of peripheral vascular disorders.

BMJ ◽  
1983 ◽  
Vol 286 (6383) ◽  
pp. 2063-2063
Author(s):  
R R Freedman ◽  
P Ianni
Keyword(s):  
Peripheral Vascular ◽  
Vascular Disorders

Use of acetaminophen during pregnancy and risk of preeclampsia, hypertensive and vascular disorders: A birth cohort study

2010 ◽  
Vol 23 (5) ◽  
pp. 371-378 ◽  
Author(s):  
Cristina Rebordosa ◽  
Carolyn M. Zelop ◽  
Manolis Kogevinas ◽  
Henrik T. Sørensen ◽  
Jørn Olsen
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Vascular Disorders ◽  
Risk Of Preeclampsia
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