Factors Controlling Exclusively the Synthesis of Collage Proteins in Fibrotic Lesion

2015 ◽  
pp. 111-122
Author(s):  
M. Chvapil ◽  
J. Hurych
Keyword(s):  
Fibrotic Lesion

Time interval from left ventricular stimulation to QRS onset is a predictor of mortality in patients with cardiac resynchronization therapy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Yagishita ◽  
Y Yagishita ◽  
S Kataoka ◽  
K Yazaki ◽  
M Kanai ◽  
...  
Keyword(s):  
Heart Failure ◽  
Independent Predictor ◽  
Total Mortality ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Time Interval ◽  
Heart Failure Hospitalization ◽  
Conduction Disturbance ◽  
Secondary Endpoints ◽  
Fibrotic Lesion

Abstract Introduction In our previous report, the time interval from left ventricular (LV) pacing to the earliest onset of QRS (S-QRS interval) has been found to be an independent predictor of mechanical response to cardiac resynchronization therapy (CRT). The S-QRS interval may indicate the conduction disturbance relevant to the localized tissue property such as scar or fibrotic lesion. Therefore, S-QRS interval longer than 37ms was associated with poor response to CRT, and proposed as suboptimal LV lead position. Then, we hypothesized that the longer S-QRS interval at the LV pacing site could be related to long term mortality and heart failure events in patients with CRT. Methods This retrospective study included 82 consecutive heart failure patients with sinus rhythm, reduced LV ejection fraction (≤35%), and a wide QRS complex (≥120ms), who undergone CRT implantation between 2012 January and 2017 December. Patients were divided into Short S-QRS group (<37ms, SS-QRS) and Long S-QRS group (≥37ms, LS-QRS) according to the previously reported optimal cut off value. A responder was defined as one with ≥15% reduction in LV end-systolic volume assessed by echocardiography at 6 months after CRT. The primary endpoint was total mortality, which included LV assist device implantation or heart transplantation. The secondary endpoints included the composite endpoint of total mortality or heart failure hospitalization. Results The study patients were divided into SS-QRS (N=43, age 65.9±13.2 years, 77% male) and LS-QRS (N=39, age 63.0±13.4, 85% male). In the electrocardiographic measurements, there were no significant differences in baseline QRS duration (162.4±30.3ms in SS-QRS vs. 154.5±31.6ms in LS-QRS, P=0.19) and LV local activation time assessed as Q-LV interval (118.3±34.3ms in SS-QRS vs. 115.3±32.0ms in LS-QRS, P=0.71). S-QRS interval was 25.9±5.3ms in SS-QRS and 51.5±13.7ms in LS-QRS (P<0.01), and the responder rate was significantly higher in SS-QRS compared with LS-QRS (79% vs. 29%, P<0.01). During mean follow up of 47.7±22.4 months, 24 patients (29%) reached to the primary endpoint, while the secondary endpoints were observed in 47 patients (57%). LS-QRS patients had significantly worse event-free survival for both primary and secondary endpoints (Figure). After the multivariate Cox regression analysis, LS-QRS (≥37ms) was an independent predictor of total mortality (HR=2.6, 95% CI: 1.11 to 6.12, P=0.03) and the secondary composite events (HR=2.4, 95% CI: 1.31 to 4.33, P<0.01). Conclusion The S-QRS interval longer than 37ms, which may reflect the conduction disturbance relevant to the scar or fibrotic lesion at the LV pacing site, was a significant predictor of the total mortality and heart failure hospitalization. These findings have implications for the optimal LV lead placement in patients with CRT device. Clinical outcomes according to S-QRS Funding Acknowledgement Type of funding source: None

Diffuse subretinal fibrosis syndrome: A rare entity

2018 ◽  
Vol 28 (6) ◽  
pp. NP1-NP6 ◽  
Author(s):  
Natacha D Stolowy ◽  
Benjamin P Donnadieu ◽  
Alban CM Comet ◽  
Sébastien Nadeau ◽  
Marie A-S Beylerian ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Subretinal Fluid ◽  
Retinal Hemorrhage ◽  
Functional Improvement ◽  
First Line ◽  
Viable Option ◽  
Systemic Corticosteroids ◽  
Subretinal Fibrosis ◽  
The Right ◽  
Fibrotic Lesion

Background/ purpose: Diffuse subretinal fibrosis and uveitis syndrome is an inflammatory disease rarely reported. The purpose of this article is to describe a rare case of diffuse subretinal fibrosis syndrome in an 8-year-old child. Methods and results: The patient initially presented with a loss of vision in his right eye, with a visual acuity of 20/200. The visual acuity of the left eye was normal. Clinical examination showed bilateral anterior and posterior inflammation while the fundus revealed on the right eye an inter maculopapillar fibrosed lesion with a discrete retinal hemorrhage and a similar but smaller lesion on the left eye. The optical coherence tomography showed hyper-reflective material compatible with pre-retinal and subretinal pigment epithelial fibrosis and associated subretinal fluid. The angiography facilitated the diagnosis of neovascularization that was associated with the fibrotic lesion. The rest of the clinical pediatric examination remained negative and a diagnosis of diffuse subretinal fibrosis syndrome complicated with neovascularization was made. Treatment with systemic corticosteroids at the dose of 1 mg/kg/day for 1 month with a progressive decrease of 5 mg per month allowed for both anatomical and functional improvement. The visual acuity of the right eye improved from 20/200 to 20/63 at 1 month, 20/32 at 2 months, and 20/20 at 4 months. Conclusion: To our knowledge, this is the first reported case of bilateral diffuse subretinal fibrosis complicated by neovascularization. General corticosteroid therapy proved to be effective in this case and appears to be a viable option in first-line treatment.

scholarly journals Re-intervention of a fibrotic lesion in a saphenous vein graft: Insights into procedural characteristics using the right transradial approach

2017 ◽  
Vol 58 (4) ◽  
pp. 297-299 ◽  
Author(s):  
Georgia Vogiatzi ◽  
Konstantinos Toutouzas ◽  
Andreas Synetos ◽  
George Latsios ◽  
Dimitris Tousoulis
Keyword(s):  
Saphenous Vein ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Transradial Approach ◽  
The Right ◽  
Fibrotic Lesion

scholarly journals The Prevalence of Active Tuberculosis Among Patients With Fibrotic Lesion in Chest CT-Scan

2013 ◽  
Author(s):  
Seyed Ali Javad Moosavi ◽  
Hanieh Raji ◽  
Mahshid Talebi-Taher ◽  
Shadi Ghourchian
Keyword(s):  
Ct Scan ◽  
Chest Ct ◽  
Active Tuberculosis ◽  
Fibrotic Lesion ◽  
Chest Ct Scan

scholarly journals Lingual Focal Hyperplastic Lesion in a Pediatric Patient: Report of an Unusual Case

2020 ◽  
pp. 155-160
Author(s):  
Denisse A. Herrera B. ◽  
Joselin Flores V. ◽  
Francisco J. Tejeda N. ◽  
Victor Fierro S. ◽  
Amaury J. Pozos G. ◽  
...  
Keyword(s):  
Unusual Case ◽  
Dorsal Surface ◽  
Surgical Excision ◽  
Laser Device ◽  
Initial Examination ◽  
Appropriate Treatment ◽  
History Of ◽  
Pedunculated Tumor ◽  
Fibrotic Lesion

Focal fibrous hyperplasia (FFH) is an oral mucosal localized non-neoplastic enlargement representing a reaction to chronic local irritations or injuries. The purpose of this report is to describe the management of an asymptomatic fibrotic lesion located in the tongue, in a preschooler boy. A 7-year-6-month old boy attended our clinic for the evaluation of an exophytic pedunculated tumor-like round mass located in the dorsal surface of the tongue. Based on the initial examination and the natural history of the lesion, the presumptive clinical diagnosis determined an irritation FFH. The lesion was surgically excised with a diode laser device, and the postoperative period evolution occurred without any complication. The appropriate treatment of FFH in children initially consists of the removal of local irritant factors. Excellent oral hygiene maintenance and close follow-up care are strongly suggested. Surgical excision is the most frequent modality for persistent lesions. Early diagnosis and proper management of FFH can reduce the risk of future recurrences or complications.

scholarly journals Neonatal Solitary Intestinal Myofibromatosis

2018 ◽  
Vol 7 (1) ◽  
pp. 7
Author(s):  
Rachida Laamiri ◽  
Nahla Kechiche ◽  
Meriem Braiki ◽  
Rim Hadhri ◽  
Lassaad Sahnoun ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Rare Case ◽  
Pediatric Population ◽  
Rare Condition ◽  
Good Prognosis ◽  
Segmental Resection ◽  
Neonatal Intestinal Obstruction ◽  
Adequate Management ◽  
Fibrotic Lesion

Solitary intestinal myofibromatosis (SIF) is a very rare condition affecting the pediatric population and carries good prognosis following adequate management based on segmental resection. We describe a rare case who presented with features of neonatal intestinal obstruction due to a solitary stenosing fibrotic lesion originating from the ileum and compatible with SIF.

Sub-chronic inhalation of reclaimed water-induced fibrotic lesion in a mouse model

2018 ◽  
Vol 139 ◽  
pp. 240-251 ◽  
Author(s):  
Jinling Xue ◽  
Jinshan Zhang ◽  
Qian-Yuan Wu ◽  
Yun Lu
Keyword(s):  
Mouse Model ◽  
Reclaimed Water ◽  
Fibrotic Lesion

The Effect of Cardiac Resynchronization Therapy and the Distribution of Ventricular Fibrotic Lesion

2007 ◽  
Vol 13 (6) ◽  
pp. S42
Author(s):  
Taka-Aki Matsuyama ◽  
Hatsue Ishibashi-Ueda ◽  
Takashi Kurita ◽  
Satoko Kitamura ◽  
Hideo Okamura ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Fibrotic Lesion
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