Studies on the Mode of Action of Vitamin D

2015 ◽  
pp. 6-16
Author(s):  
D. E. M. Lawson
Keyword(s):  
Vitamin D ◽  
Mode Of Action

scholarly journals 25-Hydroxyvitamin D Inhibits Hepatitis C Virus Production in Hepatocellular Carcinoma Cell Line by a Vitamin D Receptor-Independent Mechanism

2019 ◽  
Vol 20 (9) ◽  
pp. 2367 ◽  
Author(s):  
Amiram Ravid ◽  
Noa Rapaport ◽  
Assaf Issachar ◽  
Arie Erman ◽  
Larisa Bachmetov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Mode Of Action ◽  
Virus Production ◽  
Independent Manner ◽  
Hydroxyvitamin D ◽  
Independent Mechanism

Previously, we have reported that the active vitamin D metabolite, calcitriol and vitamin D3 (cholecalciferol), both remarkably inhibit hepatitis C virus production. The mechanism by which vitamin D3 exerts its effect is puzzling due to the low levels of calcitriol produced in vitamin D3-treated Huh7.5 cells. In this study, we aimed to explore the mechanism of vitamin D3 anti-hepatitis C virus effect. We show that vitamin D3 activity is not mediated by its metabolic conversion to calcitriol, but may be due to its primary metabolic product 25(OH)D3. This is inferred from the findings that 25(OH)D3 could inhibit hepatitis C virus production in our system, and that adequate concentrations needed to exert this effect are produced in Huh7.5 cells treated with vitamin D3. Using the CRISPR-Cas9 editing technology to knockout the vitamin D receptor, we found that the antiviral activity of vitamin D3 and 25(OH)D3 was not impaired in the vitamin D receptor knockout cells. This result indicates that 25(OH)D3 anti-hepatitis C virus effect is exerted by a vitamin D receptor-independent mode of action. The possibility that vitamin D3 and 25(OH)D3, being 3β-hydroxysteroids, affect hepatitis C virus production by direct inhibition of the Hedgehog pathway in a vitamin D receptor-independent manner was ruled out. Taken together, this study proposes a novel mode of action for the anti-hepatitis C virus activity of vitamin D3 that is mediated by 25(OH)D3 in a vitamin D receptor-independent mechanism.

scholarly journals Studies upon the mode of action of vitamin D

1937 ◽  
Vol 31 (7) ◽  
pp. 1086-1088 ◽  
Author(s):  
Ragnar Nicolaysen
Keyword(s):  
Vitamin D ◽  
Mode Of Action

The mode of action of vitamin D: A new concept

Bone ◽  
1986 ◽  
Vol 7 (5) ◽  
pp. 401
Author(s):  
S. Edelstein ◽  
S. Bar ◽  
C. Lidor ◽  
A. Harell
Keyword(s):  
Vitamin D ◽  
Mode Of Action

THE MODE OF ACTION OF VITAMIN D

1968 ◽  
Vol 43 (1) ◽  
pp. 97-135 ◽  
Author(s):  
ANTHONY W. NORMAN
Keyword(s):  
Vitamin D ◽  
Mode Of Action

Mode of Action of Vitamin D

BMJ ◽  
1945 ◽  
Vol 2 (4424) ◽  
pp. 545-545
Author(s):  
J. P. McGowan
Keyword(s):  
Vitamin D ◽  
Mode Of Action

MODE OF ACTION OF VITAMIN D.

The Lancet ◽  
1932 ◽  
Vol 219 (5673) ◽  
pp. 1104-1105
Keyword(s):  
Vitamin D ◽  
Mode Of Action

Studies on the mode of action of vitamin D XXXVII 1α-hydroxyvitamin D3: A long-acting 1,25-dihydroxyvitamin D3 analog

1983 ◽  
Vol 35 (1) ◽  
pp. 372-375 ◽  
Author(s):  
Marian R. Walters ◽  
Willi Hunziker ◽  
June E. Bishop ◽  
Anthony W. Norman
Keyword(s):  
Vitamin D ◽  
Mode Of Action ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Long Acting

scholarly journals Studies upon the mode of action of vitamin D

1937 ◽  
Vol 31 (1) ◽  
pp. 122-129 ◽  
Author(s):  
Ragnar Nicolaysen
Keyword(s):  
Vitamin D ◽  
Mode Of Action
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