The Role of Vitamin B1 in the Metabolism of Peripheral Nerve*

2015 ◽  
pp. 73-74
Author(s):  
A. von Muralt
Keyword(s):  
Peripheral Nerve ◽  
Vitamin B1

Role of Peripheral Nerve-Derived Fibroblasts and Schwann Cells in CD40/CD40L and CD80/CD86-Mediated Rejection

2006 ◽  
Vol 22 (06) ◽  
Author(s):  
Deborah Yu ◽  
Sherri Wood ◽  
Keri Smith ◽  
Keith Bishop ◽  
Paul Cederna
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells

Role of Histamine H3 and H4 Receptors in Mechanical Hyperalgesia following Peripheral Nerve Injury

2007 ◽  
Vol 14 (6) ◽  
pp. 317-325 ◽  
Author(s):  
Fiona M. Smith ◽  
Hila Haskelberg ◽  
David J. Tracey ◽  
Gila Moalem-Taylor
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Mechanical Hyperalgesia

Predictors of hospital admission after rotator cuff repair: the role of peripheral nerve blockade

2013 ◽  
Vol 30 ◽  
pp. 135-136
Author(s):  
O. Stundner ◽  
T. Danninger ◽  
R. Rasul ◽  
M. Mazumdar ◽  
P. Gerner ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Peripheral Nerve ◽  
Hospital Admission ◽  
Rotator Cuff Repair ◽  
Nerve Blockade ◽  
Peripheral Nerve Blockade ◽  
Cuff Repair

scholarly journals Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration

2021 ◽  
pp. 102482
Author(s):  
Tito Sumarwoto ◽  
Heri Suroto ◽  
Ferdiansyah Mahyudin ◽  
Dwikora Novembri Utomo ◽  
Romaniyanto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Adipose Mesenchymal Stem Cells

scholarly journals Gli1 regulates the postnatal acquisition of peripheral nerve architecture

2021 ◽  
Author(s):  
Brendan Zotter ◽  
Or Dagan ◽  
Jacob Brady ◽  
Hasna Baloui ◽  
Jayshree Samanta ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Hedgehog Signaling ◽  
Target Cells ◽  
Gli1 Expression ◽  
Desert Hedgehog ◽  
Matrix Production ◽  
Endoneurial Cells ◽  
Cellular Compartments

ABSTRACTPeripheral nerves are organized into discrete cellular compartments. Axons, Schwann cells (SCs), and endoneurial fibroblasts (EFs) reside within the endoneurium and are surrounded by the perineurium - a cellular sheath comprised of layers of perineurial glia (PNG). SC secretion of Desert Hedgehog (Dhh) regulates this organization. In Dhh nulls, the perineurium is deficient and the endoneurium is subdivided into small compartments termed minifascicles. Human Dhh mutations cause a peripheral neuropathy with similar defects. Here we examine the role of Gli1, a canonical transcriptional effector of hedgehog signaling, in regulating peripheral nerve organization. We identify PNG, EFs, and pericytes as Gli1-expressing cells by genetic fate mapping. Although expression of Dhh by SCs and Gli1 in target cells is coordinately regulated with myelination, Gli1 expression unexpectedly persists in Dhh null EFs. Thus, Gli1 is expressed in EFs non-canonically i.e., independent of hedgehog signaling. Gli1 and Dhh also have non-redundant activities. In contrast to Dhh nulls, Gli1 nulls have a normal perineurium. Like Dhh nulls, Gli1 nulls form minifascicles, which we show likely arise from EFs. Thus, Dhh and Gli1 are independent signals: Gli1 is dispensable for perineurial development but functions cooperatively with Dhh to drive normal endoneurial development. During development, Gli1 also regulates endoneurial extracellular matrix production, nerve vascular organization, and has modest, non-autonomous effects on SC sorting and myelination of axons. Finally, in adult nerves, induced deletion of Gli1 is sufficient to drive minifascicle formation. Thus, Gli1 regulates the development and is required to maintain the endoneurial architecture of peripheral nerves.SIGNIFICANCE STATEMENTPeripheral nerves are organized into distinct cellular/ECM compartments: the epineurium, perineurium and endoneurium. This organization, with its associated cellular constituents, are critical for the structural and metabolic support of nerves and their response to injury. Here, we show Gli1 - a transcription factor normally expressed downstream of hedgehog signaling - is required for the proper organization of the endoneurium but not the perineurium. Unexpectedly, Gli1 expression by endoneurial cells is independent of, and functions non-redundantly with, Schwann Cell-derived Desert Hedgehog in regulating peripheral nerve architecture. These results further delineate how peripheral nerves acquire their distinctive organization during normal development and highlight mechanisms that may regulate their reorganization in pathologic settings including peripheral neuropathies and nerve injury.

scholarly journals Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System

2017 ◽  
Vol 12 (01) ◽  
pp. e1-e6 ◽  
Author(s):  
Yigit Uyanikgil ◽  
Turker Cavusoglu ◽  
Kubilay Kılıc ◽  
Gurkan Yigitturk ◽  
Servet Celik ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Nervous System ◽  
Peripheral Nerve ◽  
Peripheral Nerve Injury ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
High Efficacy ◽  
Nerve Injuries ◽  
Age Related

This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.

The Role of Magnetic Resonance Imaging in the Management of Peripheral Nerve Tumours

1997 ◽  
Vol 22 (1) ◽  
pp. 57-60 ◽  
Author(s):  
T. E. J. HEMS ◽  
P. D. BURGE ◽  
D. J. WILSON
Keyword(s):  
Peripheral Nerve ◽  
Surgical Planning ◽  
Nerve Trunk ◽  
High Signal ◽  
Resonance Imaging ◽  
Nerve Sheath ◽  
Lipofibromatous Hamartoma ◽  
Peripheral Nerve Tumours ◽  
Nerve Tumour

Fourteen cases of peripheral nerve tumour which had been examined by MRI were reviewed. T1-weighted images showed the tumours to be of intermediate signal and T2-weighted images showed a high signal with some heterogeneity. These appearances are not specific to peripheral nerve tumours, although the diagnosis may be suggested if the lesion arises from a major nerve trunk. The association with a nerve trunk may be defined by MRI, thus assisting with surgical planning. Neurilemmomas, neurofibromas and malignant nerve sheath tumours could not be differentiated with certainty using MR alone. The MR features of lipofibromatous hamartoma are reported.

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