Does Myocardial Protection Work?

2015 ◽  
pp. 223-236
Author(s):  
Hendrick B. Barner
Keyword(s):  
Myocardial Protection

The new St Thomas' Hospital polarized cardioplegia: improved efficacy of myocardial protection in pigs on CPB

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
D. Santer ◽  
W. Dietl ◽  
K. Trescher ◽  
M. Kreibich ◽  
E. Dzilic ◽  
...  
Keyword(s):  
Myocardial Protection

Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

2015 ◽  
Vol 18 (4) ◽  
pp. 171 ◽  
Author(s):  
Tolga Demir ◽  
Mehmet Umit Ergenoglu ◽  
Hale Bolgi Demir ◽  
Nursen Tanrikulu ◽  
Mazlum Sahin ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Myocardial Protection ◽  
Troponin T ◽  
Artery Bypass ◽  
Control Group ◽  
Study Group ◽  
Cabg Surgery ◽  
Anti Inflammatory ◽  
Pump Coronary Artery Bypass

<strong>Background</strong>: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).<br /><strong>Methods</strong>: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. <br /><strong>Results</strong>: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: <br />P &lt; .001; T4: P &lt; .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group <br />(P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001).<br /><strong>Conclusions</strong>: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.<br /><br />

Comparison of myocardial protection with nifedipine and potassium.

Circulation ◽  
1979 ◽  
Vol 60 (2) ◽  
pp. 151-157 ◽  
Author(s):  
P G Magee ◽  
J T Flaherty ◽  
T J Bixler ◽  
D Glower ◽  
T J Gardner ◽  
...  
Keyword(s):  
Myocardial Protection

Myocardial Protection by Brief Ischemia in Noncardiac Tissue

Circulation ◽  
1996 ◽  
Vol 94 (9) ◽  
pp. 2193-2200 ◽  
Author(s):  
Ben C.G. Gho ◽  
Regien G. Schoemaker ◽  
Mirella A. van den Doel ◽  
Dirk J. Duncker ◽  
Pieter D. Verdouw
Keyword(s):  
Myocardial Protection

Regional myocardial protection with diltiazem in ischemic-reperfused porcine hearts

1986 ◽  
Vol 18 ◽  
pp. 123-123
Author(s):  
H KLEIN ◽  
S PICH ◽  
S LINDERT ◽  
K NEBENDAHL ◽  
H KREUZER
Keyword(s):  
Myocardial Protection

scholarly journals Total Intravenous Anesthesia for Myocardial Protection and Preconditioning

2021 ◽  
Author(s):  
Minati Choudhury
Keyword(s):  
Protective Effect ◽  
Surgical Procedure ◽  
Myocardial Protection ◽  
Myocardial Injury ◽  
Volatile Anesthetic ◽  
Organ Protection ◽  
Intravenous Anesthesia ◽  
Intravenous Anesthetic ◽  
Anesthetic Agents ◽  
Anesthetic Preconditioning

AbstractPerioperative myocardial injury is common after any major surgical procedure even with best possible anesthesia and surgical management. Organ preservation during surgical procedure prevents morbidity and mortality. The effect of ischemic preconditioning on myocardial as well as other organ protection is well known. A variety of other agents also shown to have preconditioning thus protective effect on myocardium during anesthesia and surgery. The beneficial effect of volatile anesthetic preconditioning is well studied. However, the effect of intravenous anesthetic agents on this context is still way to go. This review is an attempt to look into the latest available research regarding the preconditioning and myocardial protective effect of intravenous anesthetic agents.

scholarly journals Right ventricular myocardial protection through intracavitary cooling in cardiac operations

1989 ◽  
Vol 98 (6) ◽  
pp. 1077-1082 ◽  
Author(s):  
Antonio R. Velardi ◽  
Steven J. Widmer ◽  
Jonathan H. Cilley ◽  
Thomas A. Witkowski ◽  
Anthony J. DelRossi ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Myocardial Protection ◽  
Cardiac Operations
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