Facial Onset Sensory and Motor Neuronopathy: Further Evidence for a TDP-43 Proteinopathy
Keyword(s):
Three patients with the clinical and investigation features of facial onset sensory and motor neuronopathy (FOSMN) syndrome are presented, one of whom came to a post-mortem examination. This showed TDP-43-positive inclusions in the bulbar and spinal motor neurones as well as in the trigeminal nerve nuclei, consistent with a neurodegenerative pathogenesis. These data support the idea that at least some FOSMN cases fall within the spectrum of the TDP-43 proteinopathies, and represent a focal form of this pathology.
2009 ◽
Vol 29
(3)
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pp. 225-228
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1986 ◽
Vol 15
(2)
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pp. 95-98
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2018 ◽
Vol 164
(3)
◽
pp. 225.1-225
Keyword(s):