Effects of Methoxychlor and 2,2-bis (p-Hydroxyphenyl)-1,1,1-Trichloroethane on Cytochrome P450 Enzyme Activities in Human and Rat Livers

Pharmacology ◽  
2015 ◽  
Vol 95 (3-4) ◽  
pp. 145-153 ◽  
Author(s):  
Bingbing Chen ◽  
Peipei Pan ◽  
Li Wang ◽  
Menchun Chen ◽  
Yaoyao Dong ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Rat Livers

Microsomal cytochrome P450 enzyme activities in nonalcoholic steatohepatitis livers

2019 ◽  
Vol 34 (1) ◽  
pp. S25
Author(s):  
Maciej Czerwinski ◽  
Brian Oberheide ◽  
Nicholas Hatfield ◽  
Bill Ewy ◽  
Christopher Seib ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Nonalcoholic Steatohepatitis ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Microsomal Cytochrome ◽  
P450 Enzyme ◽  
Microsomal Cytochrome P450

Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities

2013 ◽  
Vol 59 ◽  
pp. 78-85 ◽  
Author(s):  
Yu Fen Zheng ◽  
Soo Hyeon Bae ◽  
Min Jo Kwon ◽  
Jung Bae Park ◽  
Hye Duck Choi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Inhibitory Effects ◽  
P450 Enzyme

scholarly journals Cytochrome P450 (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Kathryn Burns ◽  
Nuala Ann Helsby
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Significant Proportion ◽  
Cytochrome P450 Enzyme ◽  
Physiological Processes ◽  
P450 Enzyme ◽  
The Individual ◽  
Fat Soluble Vitamins ◽  
Extensive Family ◽  
Cyp450 Enzyme

The cytochrome P450 enzyme family (CYP450), E.C. 1.14.-.-, were originally defined by their strong absorbance at 450 nm due to the reduced carbon monoxide-complexed haem component of the cytochromes. They are an extensive family of haem-containing monooxygenases with a huge range of both endogenous and exogenous substrates. These include sterols, fat-soluble vitamins, pesticides and carcinogens as well as drugs. The substrates of some orphan CYP are not known. Listed below are the human enzymes; their relationship with rodent CYP450 enzyme activities is obscure in that the species orthologue may not catalyse the metabolism of the same substrates. Although the majority of CYP450 enzyme activities are concentrated in the liver, the extrahepatic enzyme activities also contribute to patho/physiological processes. Genetic variation of CYP450 isoforms is widespread and likely underlies a significant proportion of the individual variation to drug administration.

Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity

Planta Medica ◽  
2017 ◽  
Vol 83 (11) ◽  
pp. 895-900 ◽  
Author(s):  
Jun Yu ◽  
Min Choi ◽  
Jong Park ◽  
Shaheed Rehman ◽  
Katsunori Nakamura ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
Dependent Manner ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Concentration Dependent Manner ◽  
Garcinia Cambogia ◽  
P450 Enzyme

AbstractThis study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner. Furthermore, the inhibition was potentiated following preincubation with NADPH, indicating that G. cambogia extract is a time-dependent inhibitor of CYP2B6. Meanwhile, hydroxycitric acid, the major bioactive ingredient of G. cambogia extract, did not exhibit significant inhibition effects on cytochrome P450 enzyme activities. G. cambogia extract could modulate the pharmacokinetics of CYP2B6 substrate drugs and lead to interactions with those drugs. Therefore, caution may be required with respect to concomitant intake of dietary supplements containing G. cambogia extract with CYP2B6 substrates.

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