scholarly journals Corneal Chromoblastomycosis Caused by Fonsecaea pedrosoi

2015 ◽  
Vol 6 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Winai Chaidaroon ◽  
Napaporn Tananuvat ◽  
Pimploy Chavengsaksongkram ◽  
Nongnuch Vanittanakom
Keyword(s):  
Culture Media ◽  
Fonsecaea Pedrosoi ◽  
Corneal Ulcers ◽  
Eye Trauma ◽  
Microscopic Evaluation ◽  
Oral Itraconazole ◽  
Vegetative Matter ◽  
Diagnostic Clue ◽  
Membrane Patch ◽  
Prompt Diagnosis

Purpose: To report 2 unusual cases of fungal keratitis due to Fonsecaea pedrosoi. Methods: Two patients were diagnosed with Fonsecaea pedrosoi keratitis. Their files were reviewed for predisposing factors, clinical characteristics, microbiological study, treatment, and outcome. Results: Two consecutive patients presented with brownish pigmented corneal ulcers in their eyes after sustaining eye trauma from vegetative matter. In both cases, corneal scrapings were collected for microscopic examination and culture. Dematiaceous hyphae were seen on the smears, and dark pigmented colonies grew on the culture media, identified as F. pedrosoi. Both patients were treated and cured with combined topical antifungal agents and oral itraconazole. The first patient required an amniotic membrane patch, while the second received an intracameral amphotericin B injection. Conclusions: Pigmented infiltrates can be an important diagnostic clue, but a microscopic evaluation and culture are required to obtain an accurate diagnosis of Fonsecaea keratitis. The prompt diagnosis and combined antifungal treatment can prevent morbidity associated with this fungal infection.

scholarly journals PARACOCCIDIOIDOMYCOSIS AND AIDS: REPORT OF THE FIRST TWO COLOMBIAN CASES

1998 ◽  
Vol 40 (6) ◽  
pp. 377-381 ◽  
Author(s):  
Angela M. TOBON ◽  
Beatriz OROZCO ◽  
Santiago ESTRADA ◽  
Edilma JARAMILLO ◽  
Catalina de BEDOUT ◽  
...  
Keyword(s):  
Paracoccidioides Brasiliensis ◽  
Signs And Symptoms ◽  
Multiple Organ ◽  
The Past ◽  
Juvenile Type ◽  
Immunosuppressed Patients ◽  
Diagnostic Clue ◽  
Aids Diagnosis ◽  
Overt Disease ◽  
Prompt Diagnosis

The records of the first two Colombian patients with AIDS and paracoccidioidomycosis are presented. Both patients were males and had no known risk factors for HIV although in the past they had worked in the field where they could have been infected with the fungus. They exhibited the juvenile type of disease with multiple organ system involvement and symptoms of short duration. They were deeply immunodepressed as indicated by less than 100 CD4 T lymphocytes per mL; however, serologic tests revealed circulating anti-Paracoccidioides brasiliensis antibodies and in one patient the first diagnostic clue came from such tests. In one case, the mycosis preceded the AIDS diagnosis while in the other, both pathologies were discovered simultaneously. Antimycotic therapy with itraconazole was administered for over 10 months, with an initial dose of 200 mg/day followed by 100 mg/day; marked improvement of the mycotic signs and symptoms was soon noticed an there have been no signs of relapse. The patients´ improvement was also due to the combined retroviral treatment that was instituted. In spite of the rarity of the AIDS-paracoccidioidomycosis association, physicians practicing in endemic areas should consider the presence of the mycosis in immunosuppressed patients, since a prompt diagnosis and institution of combined antimycotic-anti-retroviral treatments would result in patient improvement and survival. It appears possible that the longer survival time of today's AIDS patients would give the quiescent fungus the opportunity to revive, multiply and cause overt disease.

scholarly journals Microbial profile in infectious keratitis over 8 years in Sao Paulo, Brazil: pathogens and microbial resistance

2021 ◽  
Author(s):  
Luiza Manhezi Shin de Oliveira ◽  
Tatiana Tanaka ◽  
Juliana Mika Kato ◽  
Regina Sayuri Yamashiro Shiotuki ◽  
Karoline de Lemes Giuntini Corrêa ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Infectious Keratitis ◽  
Microbial Keratitis ◽  
Gram Positive ◽  
Corneal Ulcers ◽  
Gram Positive Bacteria ◽  
Microbial Profile ◽  
Cutibacterium Acnes ◽  
Prompt Diagnosis ◽  
Microbiological Data

Abstract Objective Infectious keratitis remains a sight-threatening disease and its prompt diagnosis and treatment are critical. This study investigated the microbiological patterns of isolates in corneal ulcers in a tertiary health center in an 8-year period. Methods Retrospective analysis of scrapes of microbial keratitis performed from January 2013 to December 2020. Demographics and microbiological data were collected. Results A total of 446 scrapes were performed on eyes of 433 patients, 270 male (62.4%), mean age 51.7 years. 304 organisms were isolated from 248 (55.6%) positive samples. Polymicrobial infections occurred in 47 samples (19.0%). Bacterial isolates represented 86.8%: 53.3% gram-positive (GP), 33.5% gram-negative (GN). Cutibacterium acnes (12.2%) and Pseudomonas aeruginosa (9.9%) were the most common bacteria. Fungal keratitis comprised 11.8% of the isolates; Fusarium sp (6.2%) was the main fungus isolated. GP tested were sensitive to vancomycin, 98.7% of the GN were sensitive to ceftazidime. All Pseudomonas aeruginosa were sensitive to gentamicin and ciprofloxacin. Conclusion Gram-positive bacteria were predominant in keratitis isolates. In severe bacterial keratitis in our area, vancomycin should be considered as empirical treatment.

Ophthalmology

2016 ◽  
pp. 410-465
Author(s):  
Andrew Baldwin ◽  
Nina Hjelde ◽  
Charlotte Goumalatsou ◽  
Gil Myers
Keyword(s):  
Diabetes Mellitus ◽  
Contact Lenses ◽  
Systemic Disease ◽  
Eye Disease ◽  
Visual Field Defects ◽  
Loss Of Vision ◽  
Corneal Ulcers ◽  
Eye Trauma ◽  
Gradual Loss ◽  
Field Defects

This chapter explores ophthalmology, including examining eyes, aids to ophthalmoscopy, testing visual acuity, the external eye, tears and lacrimation, orbital swellings and zoster, retinoblastoma, eye movements and squint, pupils and irises, refraction; myopia; astigmatism, visual field defects, the red eye, management of corneal ulcers, sudden painless loss of vision, gradual loss of vision, chronic simple glaucoma, cataract, the retina, the eye in diabetes mellitus, the eye in systemic disease, tropical eye disease, eye trauma, blindness and partial sight, drugs and the eye, contact lenses, blepharospasm, allergic eye disease, floaters, flashes, and haloes, and refractive procedures.

scholarly journals Modified Eye Evisceration in a Tropical Screech Owl (Megascops choliba)

2021 ◽  
Vol 49 ◽  
Author(s):  
João Antonio Tadeu Pigatto ◽  
Eduarda Valim Borges De Vargas ◽  
Marcela Torikachvili ◽  
Alessandra Fernandez da Silva ◽  
Renata Lima Baptista ◽  
...  
Keyword(s):  
Postoperative Period ◽  
Postoperative Hemorrhage ◽  
Tramadol Hydrochloride ◽  
Current Case ◽  
Corneal Ulcers ◽  
Eye Trauma ◽  
Common Causes ◽  
The Right ◽  
Surgical Treatments ◽  
Surgical Manipulation

Background: An adult owl was presented with an injury to the right eye that rendered it blind in that eye. The left eye was normal. Removal of the right eye was recommended and a modified eye evisceration was performed. No complications were observed during or after surgery. The objective of this paper is to describe the modified eye evisceration technique that was successfully used in a tropical screech owl (Megascops choliba). Case: An adult owl was presented with an injury to the right eye that rendered it blind in that eye. Two previous surgical treatments have been carried out but have not been successful. Using a portable slit-lamp (Kowa SL-15®), both eyes were examined. The left eye was normal. Upon ophthalmic examination of the right eye, the owl demonstrated blepharospasm and large central corneal ulcer. Removal of the right eye was recommended. The bird received midazolam hydrochloride [Dormire® - 1 mg/kg, IM] and ketamine hydrochloride [Ketamina® - 5 mg/kg IM] as pre-anesthetic medications. Subsequently, the bird was anesthetized with isoflurane (Isoforine®) by facemask for induction, and then maintained with isoflurane vaporized in 100% oxygen through an endotracheal tube. With the aid of a surgical microscope and microsurgery materials, a modified eye evisceration was performed. Post-operatively, the owl received meloxicam [Maxicam® - 0.5 mg/kg, IM] and tramadol hydrochloride [Cronidor® - 15 mg/kg, orally for 4 days]. The day after surgery, the owl was comfortable and its usual appetite was regained. The patient remained hospitalized for 3 weeks and was evaluated daily. The skin sutures were removed 10 days after the surgical procedure and the surgical wound had healed normally. The patient was reintroduced into the wild after 2 months. During the 6 months post-release, the bird was evaluated once a month, and no complications were observed.Discussion: Severe eye trauma and complicated corneal ulcers are common causes of eyeball removal in birds. In birds, there is a high risk of complications during enucleation. The fragility of the orbital bones makes them susceptible to trauma during the surgery. Evisceration involves the removal of the inner contents of the eye while leaving the cornea and the sclera intact. In the current case, evisceration was chosen because the eye was blind, and maintaining a blind eye would be a source of pain and infection. In the modified evisceration technique, the risk of complications is minimal compared to enucleation, mainly because surgical manipulation is minimal. In our case, the total surgery time was 20 min. Another complication reported after enucleation in birds is the possibility of disfiguring the bird because the removal of the globe disturbs the natural head balance. To avoid these complications, the use of an intraocular prosthesis after evisceration in birds has been performed. However, owls have a tubular-shaped globe with scleral ossicles. These factors could hinder or even prevent the accommodation of a cylindrical silicone prosthesis. In the present case, an intraocular prosthesis implant was never considered due to the unavailability of the prosthesis and to avoid the risk of postoperative complications that have been reported from the literature in dogs. In this case, the owl recovered well from anesthesia without complications, and no postoperative hemorrhage was observed. No signs of pain were observed during the postoperative period and the owl had already shown an appetite and fed on the first postoperative day. The previously published reports using the modified evisceration technique also demonstrated an absence of pain signs during the postoperative period.

scholarly journals Corneal Phaeohyphomycosis Caused by Bipolaris hawaiiensis

2016 ◽  
Vol 7 (2) ◽  
pp. 364-371 ◽  
Author(s):  
Winai Chaidaroon ◽  
Sumet Supalaset ◽  
Napaporn Tananuvat ◽  
Nongnuch Vanittanakom
Keyword(s):  
Fungal Infection ◽  
Penetrating Keratoplasty ◽  
Corneal Ulcer ◽  
Nucleotide Sequence Analysis ◽  
Laboratory Findings ◽  
History Of ◽  
Oral Itraconazole ◽  
Eye Examination ◽  
Diagnostic Clue ◽  
Therapeutic Penetrating Keratoplasty

Purpose: To report a rare case of keratitis infected by Bipolaris hawaiiensis. Methods: A patient who was diagnosed as fungal keratitis caused by B. hawaiiensis was retrospectively reviewed for history, clinical characteristics, risk factors, laboratory findings, treatments, and outcomes. Results: A 63-year-old man with a history of trauma and saw dust in the left eye presented with a corneal ulcer. Eye examination revealed whitish infiltration with a feathery edge and small brownish deposits in the anterior stroma of the left cornea. Numerous septate hyphal fragments were detected in a corneal specimen, and nucleotide sequence analysis identified B. hawaiiensis. Treatment was started with 5% natamycin eyedrops and oral itraconazole. Subsequently, a corneal plaque developed which did not respond to medication and debridement. The patient underwent therapeutic penetrating keratoplasty. Conclusions: B. hawaiiensis is a rare cause of corneal phaeohyphomycosis. A brownish pigmented infiltration is an important diagnostic clue, however microbiologic studies are required to obtain a definite diagnosis. Although antifungal medication and debridement are the mainstay of most corneal fungal infection, therapeutic penetrating keratoplasty can prevent morbidity related to this fungal infection.

scholarly journals A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine

2020 ◽  
Vol 10 (2) ◽  
pp. 321-327 ◽  
Author(s):  
Xu-Cheng Shen ◽  
Xiang-Nong Dai ◽  
Zhi-Min Xie ◽  
Ping Li ◽  
Sha Lu ◽  
...  
Keyword(s):  
Fonsecaea Pedrosoi ◽  
Oral Itraconazole

FONSECAEA PEDROSOI – A CAUSE OF OCCULAR CHROMOBLASTOMYCOSIS

2021 ◽  
pp. 69-70
Author(s):  
Shrutikirti Shrutikirti ◽  
Ashwini Dedwal ◽  
Sushma Pednekar ◽  
Rajesh Karyakarte
Keyword(s):  
Case Report ◽  
Clinical Condition ◽  
Mycotic Keratitis ◽  
Fonsecaea Pedrosoi ◽  
Common Cause ◽  
Exposed Skin ◽  
Dematiaceous Fungus ◽  
Corneal Sample ◽  
Prompt Diagnosis ◽  
Vigorous Treatment

Fonsecaea pedrosoi (F. pedrosoi) is dematiaceous fungus and is the most common cause for chromoblastomycosis. It affects the exposed skin, mostly of the lower extremities. Arare case of mycotic keratitis was diagnosed in our hospital caused by F. pedrosoi. Corneal sample received in the laboratory was processed by standard mycological methods, F. pedrosoi was isolated, patient was started on antifungals his condition improved and there was no relapse. This case report shows that F. pedrosoi can infect cornea. Further, a prompt diagnosis and vigorous treatment improves patient's clinical condition.

scholarly journals Development of Natural Culture Media for Rapid Induction of Fonsecaea pedrosoi Sclerotic Cells In Vitro

2008 ◽  
Vol 46 (11) ◽  
pp. 3839-3841 ◽  
Author(s):  
M. B. da Silva ◽  
J. P. da Silva ◽  
S. Sirleide Pereira Yamano ◽  
U. I. Salgado ◽  
J. A. P. Diniz ◽  
...  
Keyword(s):  
Culture Media ◽  
Fonsecaea Pedrosoi ◽  
Rapid Induction

Delayed-type Hypersensitivity Response to Crude and Fractionated Antigens from Fonsecaea pedrosoi CMMI 1 Grown in Different Culture Media

2006 ◽  
Vol 162 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Valeriano Antonio Corbellini ◽  
Maria Lúcia Scroferneker ◽  
Mariana Carissimi ◽  
Luciane Domingues Santolin
Keyword(s):  
Culture Media ◽  
Delayed Type Hypersensitivity ◽  
Hypersensitivity Response ◽  
Fonsecaea Pedrosoi ◽  
Delayed Type Hypersensitivity Response

ASPERGILLUS SP. PADA ULKUS KORNEA

2020 ◽  
Vol 5 (2) ◽  
pp. 511
Author(s):  
Hesty Rhauda Ashan ◽  
Ellyza Nasrul ◽  
Abdul Aziz Djamal
Keyword(s):  
Contact Lenses ◽  
Corneal Ulcer ◽  
Culture Media ◽  
Fungal Culture ◽  
Corneal Surgery ◽  
Corneal Ulcers ◽  
Main Complaint ◽  
Aspergillus Sp ◽  
The Right ◽  
Tropical Climates

<p><em>Aspergillosis is a disease caused by Aspergillus sp., especially Aspergillus fumigatus which induce granulomatosis inflammation in mucous membranes, eyes, bronchi, ears. Aspergillus sp. microscopically characterized as septate and branched hyphae. Fungal corneal ulcers are more common in tropical climates. Aspergillus sp. is the most common fungi causes corneal ulcer. Risk factors include the use of antibiotics, long-term corticosteroids, trauma, contact lenses, and corneal surgery. 50-year-old female with main complaint: increased redness and pain of the right eye after trauma from twig. Palpebral edema, conjunctival injection, ciliary injection, corneal ulcers, maceration, and impending were found from physical examination of the right eye. Fungal culture on sabouraud dextrose agar (SDA) culture media found growth of fungi Aspergillus sp. which macroscopically has fertile hyphae on the surface and vegetative hyphae below the surface, and microscopically characterized as septate and branching hyphae. Corneal ulcers in the tropics are mostly caused by fungi. Aspergillus sp. and Fusarium sp. is most commonly found in tropical climates, while Candida is more commonly found in cold climates. Diagnosis of corneal ulcer ec Aspergillus sp. is obtained based on history, clinical manifestation and found Aspergillus sp. from fungal culture</em><em>.</em></p>

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