Effectiveness of Rapid Intake into Methadone Treatment: A Natural Experiment in Israel

2015 ◽  
Vol 21 (4) ◽  
pp. 211-216 ◽  
Author(s):  
Maayan Lawental
Keyword(s):  
Group Treatment ◽  
Natural Experiment ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Treatment Retention ◽  
Control Group ◽  
Treatment Entry ◽  
Retention In Treatment ◽  
Rapid Intake ◽  
Regular Intake

The effect of intake procedures on treatment entry and retention was examined in a natural experiment, in which a methadone maintenance clinic in Israel admitted 127 clients by employing a rapid intake procedure (maximum of 3 days before the initiation of treatment was offered). Using information gathered from patient files, these clients were retrospectively compared to a control group (n = 121) who underwent the clinic's regular intake procedure (between 3 weeks and 3 months). Outcome measures included entry into treatment and subsequent retention in treatment (at 3, 6 and 12 months). Results show that 81% of clients from the rapid intake group entered treatment compared to only 57% from the regular intake group. Treatment retention was similar for both groups. In addition, Jewish clients were more likely to enter treatment via the rapid intake procedure than clients from other religions, and women were retained in treatment longer than men, regardless of the type of intake procedure. Results of this single-site study lend support to the effectiveness of rapid intake procedures as a way to engage clients in treatment and carry significant implications for improving access into treatment.

A Procedure for Assessing the Validity of Self-Report Data on High-Risk Sex Behaviors from Heroin Addicts Entering Free Methadone Treatment

1995 ◽  
Vol 25 (4) ◽  
pp. 723-733 ◽  
Author(s):  
Christine E. Grella ◽  
Shama Chaiken ◽  
M. Douglas Anglin
Keyword(s):  
High Risk ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Self Report ◽  
Heroin Addicts ◽  
Sex Behaviors ◽  
Benzodiazepine Use ◽  
Treatment Entry ◽  
Self Report Data ◽  
Reported Data

A procedure is described for determining the validity of self-reported high-risk sex behaviors obtained from heroin addicts entering a research demonstration project providing free methadone maintenance. The procedure included: classifying subjects with inconsistencies in self-reported data provided at eligibility screening and later interviews as “falsifiers;” comparing admitted or suspected falsifiers with others on a range of background variables; and comparing the rate of inconsistency between self-reported drug use and urinalysis results for falsifiers and non-falsifiers. Falsifiers were more likely to be older and male and to fail to report cocaine use at treatment entry; non-falsifiers were more likely to underreport benzodiazepine use at follow-up. Falsifiers did not differ in their personality characteristics, and thus were probably responding to perceived situational consequences. Researchers offering free treatment need to use a variety of means for obtaining information to validate self-reported risk behavior.

Efficacy of Heroin-Assisted Treatment in Belgium: A Randomised Controlled Trial

2015 ◽  
Vol 21 (4) ◽  
pp. 179-187 ◽  
Author(s):  
Isabelle Demaret ◽  
Etienne Quertemont ◽  
Géraldine Litran ◽  
Cécile Magoga ◽  
Clémence Deblire ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Methadone Maintenance ◽  
Controlled Trial ◽  
Methadone Treatment ◽  
Control Group ◽  
Heroin Addicts ◽  
Heroin Use ◽  
Significant Difference ◽  
Randomised Controlled ◽  
Experimental Group

Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT to existing methadone maintenance treatment. Methods: In this randomised controlled trial, HAT was limited to 12 months. Participants were assessed every 3 months. They were responders if they showed improvement on the level of street heroin use, health or criminal involvement. Results: 74 participants were randomised in the trial. The experimental group (n = 36) counted 30% of responders more than the control group (n = 38) at each assessment point (p < 0.05), except at 12 months where the difference (11%) was no longer significant (p = 0.35). Still, after 12 months, participants in the experimental group reported significantly greater improvements (p < 0.05) than the control group on the level of street heroin use and on the level of physical and mental health. Both groups reported significantly less criminal acts after 12 months (p < 0.001), but with no significant difference between the groups. Conclusions: This trial confirms the short-term efficacy of HAT for severe heroin addicts, who already failed methadone treatment.

Perbandingan Efek Suplementasi Tablet Tambah Darah Dengan Dan Tanpa Vitamin C Terhadap Kadar Hemoglobin Pada Ibu Hamil Dengan Usiakehamilan 16-32 Minggu Di Desa Keniten Kecamatan Mojo Kabupaten Kediri

2017 ◽  
Vol 3 (1) ◽  
pp. 76
Author(s):  
Siti Asiyah ◽  
Dwi Estuning Rahayu ◽  
Wiranti Dwi Novita Isnaeni
Keyword(s):  
Treatment Group ◽  
Vitamin C ◽  
Gestational Age ◽  
Group Treatment ◽  
Sampling Technique ◽  
Hemoglobin Level ◽  
The Body ◽  
Control Group ◽  
Fetal Organ ◽  
And Control

The needed of Iron Tablet in pregnancy was increase than mother who not pregnant.  That  cause of  high metabolism at the pregnancy for formed of  fetal organ and energy. One of effort for prevent anemia in mother pregnant with giving the Iron tablet and vitamin c. The reason of  this research in 4 June – 11 July 2014 is for compare the effect of  iron tablet suplementation with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks In Desa Keniten Kecamatan Mojo Kabupaten Kediri. This research method using comparative analytical.  Research design type of Quasy Eksperiment that have treatment group and control group. Treatment group will giving by Iron tablet and 100 mg vitamin C, and control group just giving by iron tablet during 21 days. Population in this research are all of mother pregnant with Gestational Age Of 16-32 Weeks with Sampling technique is  cluster random sampling is 29 mother pregnant. Comparison analysis of  iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks, data analysis using Mann Whitney U-test and the calculated U value (44,5) less than U-table (51). So there was difference of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks Therefore, the addition of vitamin C on iron intake is needed to increase the uptake of iron tablets. When the amount of iron uptake increases, the reserves of iron in the body will also increase, so as to prevent anemia in pregnant women; Keywords : Iron Tablet (Fe), Vitamin C, Hemoglobin level, Mother Pregnant

Legal Pressure in Therapeutic Communities

1988 ◽  
Vol 18 (4) ◽  
pp. 625-640 ◽  
Author(s):  
George De Leon
Keyword(s):  
Substance Abusers ◽  
Therapeutic Community ◽  
Recovery Process ◽  
Treatment Retention ◽  
Therapeutic Communities ◽  
Compulsory Treatment ◽  
Differential Outcomes ◽  
Retention In Treatment ◽  
Legal Pressure ◽  
Indirect Relationship

Therapeutic community (TC) studies are reviewed to assess the effects of legal referral on treatment retention and outcome. The main findings reveal little evidence for differential outcomes between legally referred and non-legally referred clients in TCs, although legal referrals to TCs remain longer in treatment than do “voluntary” clients. Thus, there is an indirect relationship between legal referral and outcome which is mediated through retention in treatment. Issues are discussed which have confounded interpretation of research on the efficacy of compulsory treatment, e.g., definitions, client perception of pressure, implementation of legal referral procedures and the complexity of the recovery process itself. It is hypothesized that legal pressure can have a limited but potent role in the recovery process for appropriately identified substance abusers.

scholarly journals A Randomized Controlled Trial Evaluating Integrative Psychotherapeutic Group Treatment Compared to Self-Help Groups in Functional Vertigo/Dizziness

2021 ◽  
Vol 10 (10) ◽  
pp. 2215
Author(s):  
Karina Limburg ◽  
Katharina Radziej ◽  
Heribert Sattel ◽  
Peter Henningsen ◽  
Marianne Dieterich ◽  
...  
Keyword(s):  
Group Treatment ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Controlled Trial ◽  
Clinical Psychologist ◽  
Control Group ◽  
Attrition Rates ◽  
Randomized Controlled ◽  
Self Help ◽  
Self Help Groups

We tested the efficacy of an integrative psychotherapeutic group treatment (IPGT) in reducing vertigo/dizziness-related impairment along with depression, anxiety, and somatization by conducting a randomized controlled superiority trial comparing IPGT to self-help groups moderated by a clinical psychologist (SHG). Adult patients with functional vertigo and dizziness symptoms were randomly allocated to either the IPGT or SHG as active control group. Outcomes were assessed at baseline (t0), after treatment lasting 16 weeks (t1), and 12 months after treatment (t2). A total of 81 patients were assigned to IPGT and 78 patients were assigned to SHG. Vertigo-related impairment was reduced in both conditions (IPGT: t0–t1: d = 1.10, t0–t2: d = 1.06; SHG: t0–t1: d = 0.86, t0–t2: d = 1.29), showing the efficiency of both IPGT and SHG. Clinically relevant improvements were also obtained for depression in both groups. Linear mixed model analyses revealed no differences between groups for all outcomes (effect of group for the primary outcome: b = −1.15, SE = 2.13, t = −0.54, p = 0.59). Attrition rates were higher in SHG (52.6%) than in IPGT (28.4%). Both conditions improved primary and secondary outcomes while IPGT was better accepted by patients than SHG. Trial registration: ClinicalTrials.gov, Identifier: NCT02320851.

scholarly journals Response of Photosynthesis and Chlorophyll Fluorescence Parameters of Castanopsis kawakamii Seedlings to Forest Gaps

Forests ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 21
Author(s):  
Zhong-sheng He ◽  
Rong Tang ◽  
Meng-jia Li ◽  
Meng-ran Jin ◽  
Cong Xin ◽  
...  
Keyword(s):  
Chlorophyll Fluorescence ◽  
Light Intensity ◽  
Seedling Growth ◽  
Group Treatment ◽  
Control Group ◽  
Low Light ◽  
Chlorophyll Fluorescence Parameters ◽  
Forest Gaps ◽  
Low Light Intensity ◽  
Weak Light

Light is a major environmental factor limiting the growth and survival of plants. The heterogeneity of the light environment after gap formation in forest influences the leaf chlorophyll contents, net photosynthetic rate (Pn), and chlorophyll fluorescence, thus influencing the growth and regeneration of Castanopsis kawakamii seedlings. The aim of this study was to explore the effects of weak light on the photosynthetic physiology of C. kawakamii seedlings in forest gaps and non-gaps. The results showed that (1) the contents of chlorophyll a (Chl-a), chlorophyll b (Chl-b), and total chlorophyll (Chl-T) in forest gaps were lower than in non-gaps. Seedlings tended to increase chlorophyll content to absorb light energy to adapt to low light intensity in non-gap environments. (2) The Pn values of C. kawakamii seedlings in forest gaps were significantly higher than in non-gaps, and forest gaps could improve the seedlings’ photosynthetic capacity. (3) The C. kawakamii seedlings in forest gaps were more sensitive to weak light and control group treatment, especially the tall seedlings, indicating that seedlings require more light to satisfy their growth needs in the winter. The seedlings in non-gaps demonstrated better adaptability to low light intensity. The light intensity was not adequate in weak light conditions and limited seedling growth. We suggest that partial forest selection cutting could improve light intensity in non-gaps, thus promoting seedling growth and regeneration of C. kawakamii more effectively in this forest.

Effect of Curculigo orchioides on Reflux Esophagitis by Suppressing Proinflammatory Cytokines

2012 ◽  
Vol 40 (06) ◽  
pp. 1241-1255 ◽  
Author(s):  
Sae-Kang Ku ◽  
Jae-Soo Kim ◽  
Young-Bae Seo ◽  
Yong-Ung Kim ◽  
Seung-Lark Hwang ◽  
...  
Keyword(s):  
Reflux Esophagitis ◽  
Group Treatment ◽  
Control Group ◽  
Esophageal Mucosa ◽  
Dependent Manner ◽  
Protective Effects ◽  
Model Group ◽  
Curculigo Orchioides ◽  
Intact Group ◽  
Tnf Α

This study was performed to investigate effects of Curculigo orchioides rhizome (curculiginis rhizome) on acute reflux esophigitis (RE) in rats that are induced by pylorus and forestomach ligation operation. Proinflammatory cytokine, as well as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were all assayed and the expression of TNF-α and COX2 analyzed by RT-PCR. The esophagic tissue damage of reflux esophagitis rat was increased compared to that of normal intact group. However, the esophagic damage percentage from the extract of curculiginis rhizoma (ECR) 600 mg/kg and ECR 300 mg/kg were significantly lower than that of the RE control group. Administration of α-tocopherol (30 mg/kg) and ECR (600 mg/kg, 300 mg/kg, and 150 mg/kg) had a significant effect on the gastric acid pH in rats with induced reflux esophagitis (p < 0.05). The treatment with ECR significantly reduced the production of cytokines TNF-α, IL-1β and IL-6 levels compared to the model group (p < 0.05). The expression of TNF-α and COX2 in the intact esophageal mucosa was low while those of the RE control group were significantly higher due to an inflammatory reaction in the esophagus. Compare to the model group, treatment with α-tocopherol or ECR significantly inhibited the expression levels of COX2 and TNF-α in a dose-dependent manner. These results suggest that anti-inflammatory and protective effects of ECR could attenuate the severity of reflux esophagitis and prevent esophageal mucosal damage.

Differential Effects of Maternal Heroin and Methadone Use on Birthweight

PEDIATRICS ◽  
1976 ◽  
Vol 58 (5) ◽  
pp. 681-685
Author(s):  
Stephen R. Kandall ◽  
Susan Albin ◽  
Joyce Lowinson ◽  
Beatrice Berle ◽  
Arthur I. Eidelman ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Methadone Maintenance ◽  
First Trimester ◽  
Control Group ◽  
Fetal Growth Retardation ◽  
Intrauterine Growth ◽  
Methadone Dosage ◽  
History Of

An analysis of birthweights of 337 neonates in relation to history of maternal narcotic usage was undertaken Mean birthweight of infants born to mothers abusing heroin during the pregnancy was 2,490 gm, an effect primarily of intrauterine growth retardation. Low mean birthweight (2,615 gm) was also seen in infants born to mothers who had abused heroin only prior to this pregnancy, and mothers who had used both heroin and methadone during the pregnancy (2,535 gm). Infants born to mothers on methadone maintenance during the pregnancy had significantly higher mean birthweights (2,961 gm), but lower than the control group (3,176 gm). A highly significant relationship was observed between maternal methadone dosage in the first trimester and birthweight, i.e., the higher the dosage, the larger the infant. Heroin causes fetal growth retardation, an effect which may persist beyond the period of addiction. Methadone may promote fetal growth in a dose-related fashion after maternal use of heroin.

Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment

2021 ◽  
Author(s):  
Xiaohu Xie ◽  
Jun Gu ◽  
Dingding Zhuang ◽  
Xiaoyu Chen ◽  
Yun Zhou ◽  
...  
Keyword(s):  
Treatment Response ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Heroin Addiction ◽  
High Dose ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Delta Subunit

Aim: This study determined if gene variants in the GABA receptor delta subunit ( GABRD) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. Materials & methods: A total of 286 MMT patients were recruited and divided into response and nonresponse groups based on retention time in therapy. A total of 177 responders were classified into low dose and high dose subgroups according to the stabilized methadone dose. Four (single nucleotide polymorphisms) SNPs (rs13303344, rs4481796, rs2376805 and rs2229110) in GABRD were genotyped using the TaqMan SNP assay. Logistic regression was used to assess the genetic effects of the SNPs in MMT. Results: No significant associations were observed between the SNPs and treatment response or dose, except the frequency of haplotype ACGC at the four SNPs significantly differed between responders and nonresponders. Conclusion: The results indicated that GABRD variants may play a small role in modulating methadone treatment response.

Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss

2018 ◽  
Vol 132 (11) ◽  
pp. 995-999 ◽  
Author(s):  
F Gündoğan ◽  
A Bayram ◽  
M Kalkan ◽  
İ Özcan
Keyword(s):  
Hearing Loss ◽  
Endothelial Cell ◽  
Sensorineural Hearing Loss ◽  
Group Treatment ◽  
Plasma Levels ◽  
Pure Tone Audiometry ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Pentraxin 3

AbstractObjectivesTo evaluate the plasma levels of endothelial cell-specific molecule-1 (ESM-1) and pentraxin-3 (PTX-3) in patients with idiopathic sudden sensorineural hearing loss, and to compare the pre- and post-treatment levels in patients responsive and non-responsive to therapy.MethodsThe study included 108 subjects: 51 with idiopathic sudden sensorineural hearing loss and 57 controls. For ESM-1 and PTX-3 analyses, blood samples were collected before and three months after treatment initiation in the idiopathic sudden sensorineural hearing loss group and once for the control group. Treatment response was evaluated three months after therapy initiation with pure tone audiometry, and the patients were divided into two groups: responsive and non-responsive to treatment.ResultsSerum ESM-1 levels were significantly higher in the idiopathic sudden sensorineural hearing loss group than the control group, whereas the difference was not significant for PTX-3. In the responsive and non-responsive groups, ESM-1 and PTX-3 levels were not statistically different before and after treatment.ConclusionTo our knowledge, this is the first study investigating plasma ESM-1 and PTX-3 levels in idiopathic sudden sensorineural hearing loss. Increased plasma ESM-1 levels may confirm endothelial dysfunction involvement in idiopathic sudden sensorineural hearing loss pathogenesis, which could be associated with vascular impairment.

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