A Cell Type-Specific Role of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Regulating ER Stress Signalling

Digestion ◽  
2015 ◽  
Vol 91 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Stephanie H. Kasper ◽  
Marianne R. Spalinger ◽  
Tina Raselli ◽  
Michael Scharl
Keyword(s):  
Er Stress ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Specific Role ◽  
Receptor Type ◽  
Cell Type ◽  
A Cell ◽  
Cell Type Specific

scholarly journals Genetic Deletion of SEPT7 Reveals a Cell Type-Specific Role of Septins in Microtubule Destabilization for the Completion of Cytokinesis

PLoS Genetics ◽  
2014 ◽  
Vol 10 (8) ◽  
pp. e1004558 ◽  
Author(s):  
Manoj B. Menon ◽  
Akihiro Sawada ◽  
Anuhar Chaturvedi ◽  
Pooja Mishra ◽  
Karin Schuster-Gossler ◽  
...  
Keyword(s):  
Specific Role ◽  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Genetic Deletion

scholarly journals Inhibitory Effects of Secondary Metabolites from the Lichen Stereocaulon evolutum on Protein Tyrosine Phosphatase 1B

Planta Medica ◽  
2021 ◽  
Author(s):  
Birgit Waltenberger ◽  
Françoise Lohézic-Le Dévéhat ◽  
Thi Huyen Vu ◽  
Olivier Delalande ◽  
Claudia Lalli ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Inhibitory Activity ◽  
Tyrosine Phosphatase ◽  
Inhibitory Effect ◽  
Positive Control ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Ic50 Values ◽  
A Cell

AbstractProtein tyrosine phosphatase 1B plays a significant role in type 2 diabetes mellitus and other diseases and is therefore considered a new drug target. Within this study, an acetone extract from the lichen Stereocaulon evolutum was identified to possess strong protein tyrosine phosphatase 1B inhibition in a cell-free assay (IC50 of 11.8 µg/mL). Fractionation of this bioactive extract led to the isolation of seven known molecules belonging to the depsidones and the related diphenylethers and one new natural product, i.e., 3-butyl-3,7-dihydroxy-5-methoxy-1(3H)-isobenzofurane. The isolated compounds were evaluated for their inhibition of protein tyrosine phosphatase 1B. Two depsidones, lobaric acid and norlobaric acid, and the diphenylether anhydrosakisacaulon A potently inhibited protein tyrosine phosphatase 1B with IC50 values of 12.9, 15.1, and 16.1 µM, respectively, which is in the range of the protein tyrosine phosphatase 1B inhibitory activity of the positive control ursolic acid (IC50 of 14.4 µM). Molecular simulations performed on the eight compounds showed that i) a contact between the molecule and the four main regions of the protein is required for inhibitory activity, ii) the relative rigidity of the depsidones lobaric acid and norlobaric acid and the reactivity related to hydrogen bond donors or acceptors, which interact with protein tyrosine phosphatase 1B key amino acids, are involved in the bioactivity on protein tyrosine phosphatase 1B, iii) the cycle opening observed for diphenylethers decreased the inhibition, except for anhydrosakisacaulon A where its double bond on C-8 offsets this loss of activity, iv) the function present at C-8 is a determinant for the inhibitory effect on protein tyrosine phosphatase 1B, and v) the more hydrogen bonds with Arg221 there are, the more anchorage is favored.

scholarly journals Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

2020 ◽  
Vol 11 ◽  
Author(s):  
Larissa Hering ◽  
Egle Katkeviciute ◽  
Marlene Schwarzfischer ◽  
Philipp Busenhart ◽  
Claudia Gottier ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine

scholarly journals The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort

Digestion ◽  
2016 ◽  
Vol 93 (3) ◽  
pp. 182-192 ◽  
Author(s):  
Marianne R. Spalinger ◽  
Marius Voegelin ◽  
Luc Biedermann ◽  
Jonas Zeitz ◽  
Jean-Benoit Rossel ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Clinical Relevance ◽  
Gene Locus ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Risk Gene ◽  
Encoding Protein

Tu1740 Matriptase-1 Modulation of Claudin-2 Is Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Dependent

2013 ◽  
Vol 144 (5) ◽  
pp. S-834
Author(s):  
Ronald R. Marchelletta ◽  
Taylaur W Smith ◽  
Jessica A. Bañuelos ◽  
Carli Smith ◽  
Brian Houng ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine

scholarly journals Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity

2016 ◽  
Vol 291 (35) ◽  
pp. 18117-18128 ◽  
Author(s):  
Kazuya Kuboyama ◽  
Akihiro Fujikawa ◽  
Ryoko Suzuki ◽  
Naomi Tanga ◽  
Masaharu Noda
Keyword(s):  
Chondroitin Sulfate ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine
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