scholarly journals Differential T-Helper Cell Polarization after Allergen-Specific Stimulation of Autologous Dendritic Cells in Polysensitized Allergic Patients

2015 ◽  
Vol 166 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Kazem Ashjaei ◽  
Merima Bublin ◽  
Ursula Smole ◽  
Nina Lengger ◽  
Christine Hafner ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Polarization ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Specific Stimulation ◽  
Stimulation Of

scholarly journals Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Sonja I. Gringhuis ◽  
Tanja M. Kaptein ◽  
Brigitte A. Wevers ◽  
Michiel van der Vlist ◽  
Elsenoor J. Klaver ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Polarization ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

scholarly journals Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization

2019 ◽  
Vol 58 ◽  
pp. 16-23 ◽  
Author(s):  
Thiago A Patente ◽  
Leonard R Pelgrom ◽  
Bart Everts
Keyword(s):  
Dendritic Cells ◽  
Cell Polarization ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization

2016 ◽  
Vol 76 ◽  
pp. 22-34 ◽  
Author(s):  
Marise L. Fermino ◽  
L. Sebastian D. Dylon ◽  
Nerry T. Cecílio ◽  
Sofia N. Santos ◽  
Marta A. Toscano ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Cell Polarization ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Galectin 3 ◽  
Notch Activation

Induction of Type 2 T Helper Cell Allergen Tolerance by IL-10–Differentiated Regulatory Dendritic Cells

2010 ◽  
Vol 42 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Xiuling Li ◽  
Aimei Yang ◽  
Hui Huang ◽  
Xiaobei Zhang ◽  
Jennifer Town ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Regulatory Dendritic Cells

scholarly journals CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 ◽  
Vol 198 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Guillaume Oldenhove ◽  
Magali de Heusch ◽  
Georgette Urbain-Vansanten ◽  
Jacques Urbain ◽  
Charlie Maliszewski ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Peripheral Tolerance ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

Recent evidence suggests that in addition to their well known stimulatory properties, dendritic cells (DCs) may play a major role in peripheral tolerance. It is still unclear whether a distinct subtype or activation status of DC exists that promotes the differentiation of suppressor rather than effector T cells from naive precursors. In this work, we tested whether the naturally occurring CD4+ CD25+ regulatory T cells (Treg) may control immune responses induced by DCs in vivo. We characterized the immune response induced by adoptive transfer of antigen-pulsed mature DCs into mice depleted or not of CD25+ cells. We found that the development of major histocompatibility complex class I and II–restricted interferon γ–producing cells was consistently enhanced in the absence of Treg. By contrast, T helper cell (Th)2 priming was down-regulated in the same conditions. This regulation was independent of interleukin 10 production by DCs. Of note, splenic DCs incubated in vitro with Toll-like receptor ligands (lipopolysaccharide or CpG) activated immune responses that remained sensitive to Treg function. Our data further show that mature DCs induced higher cytotoxic activity in CD25-depleted recipients as compared with untreated hosts. We conclude that Treg naturally exert a negative feedback mechanism on Th1-type responses induced by mature DCs in vivo.

scholarly journals ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling

Blood ◽  
2010 ◽  
Vol 116 (17) ◽  
pp. 3208-3218 ◽  
Author(s):  
Daniel B. Graham ◽  
Holly M. Akilesh ◽  
Grzegorz B. Gmyrek ◽  
Laura Piccio ◽  
Susan Gilfillan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mhc Class Ii ◽  
Autoimmune Encephalitis ◽  
Class Ii ◽  
T Helper Cell ◽  
Helper Cell ◽  
Nucleotide Exchange ◽  
T Helper

Abstract Immature dendritic cells (DCs) specialize in antigen capture and maintain a highly dynamic pool of intracellular major histocompatibility complex class II (MHCII) that continuously recycles from peptide loading compartments to the plasma membrane and back again. This process facilitates sampling of environmental antigens for presentation to T helper cells. Here, we show that a signaling pathway mediated by the DC immunoreceptor tyrosine-based activation motif (ITAM)–containing adaptors (DAP12 and FcRγ) and Vav family guanine nucleotide exchange factors controls the half-life of surface peptide-MHCII (pMHCII) complexes and is critical for CD4 T-cell triggering in vitro. Strikingly, mice with disrupted DC ITAMs show defective T helper cell priming in vivo and are protected from experimental autoimmune encephalitis. Mechanistically, we show that deficiency in ITAM signaling results in increased pMHCII internalization, impaired recycling, and an accumulation of ubiquitinated MHCII species that are prematurely degraded in lysosomes. We propose a novel mechanism for control of T helper cell priming.

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