scholarly journals The Role of Rare Variants in Systolic Blood Pressure: Analysis of ExomeChip Data in HyperGEN African Americans

2015 ◽  
Vol 79 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Yun Ju Sung ◽  
Jacob Basson ◽  
Nuo Cheng ◽  
Khanh-Dung H. Nguyen ◽  
Priyanka Nandakumar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
African Americans ◽  
Systolic Blood Pressure ◽  
Rare Variants ◽  
Pressure Analysis

High Systolic Blood Pressure after Successful Endovascular Treatment Affects Early Functional Outcome in Acute Ischemic Stroke

2017 ◽  
Vol 45 (1-2) ◽  
pp. 18-25 ◽  
Author(s):  
Ilko L. Maier ◽  
Ioannis Tsogkas ◽  
Daniel Behme ◽  
Mathias Bähr ◽  
Michael Knauth ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Systolic Blood Pressure ◽  
Endovascular Treatment ◽  
Functional Outcome ◽  
Vessel Occlusion ◽  
High Systolic Blood Pressure ◽  
Cerebral Vessel ◽  
Early Functional Outcome

Background: Endovascular treatment (EVT) has been shown to significantly improve functional outcome in patients with acute large cerebral vessel occlusions. To date, no evidence-based recommendations on blood pressure management after successful EVT exist. Previous studies showed an association between high pre-EVT systolic blood pressure (SBP) and functional outcome, but do not answer the question on how to manage blood pressure after successful recanalization. The purpose of this study was to determine the role of blood pressure measurements as a predictor for early functional outcome in patients with successful EVT. Methods: Prospectively derived data from patients with acute large vessel occlusion within the anterior circulation and EVT was analyzed in this monocentric study. Mean systolic- and maximum SBP as well as SBP-peaks have been obtained for the first 24 h after successful EVT. Predictive value of SBP for discharge modified Rankin Scale (mRS) ≤2 has been investigated using logistic regression models. Results: From 168 patients with successful EVT, 74 (44%) had a favorable outcome with an mRS ≤2. Mean- (127 vs. 131 mm Hg, p = 0.035) and maximum SBP (157 vs. 169 mm Hg, p < 0.001) as well as the number of SBP-peaks (0 vs. 1.5, p = 0.004) were lower in patients with favorable outcomes. Multivariable logistic regression showed high mean- and maximum SBP to predict unfavorable outcomes. Cutoff mean SBP was 141 mm Hg and maximum SBP 159 mm Hg. Conclusions: High SBP in the first 24 h after recanalization of acute anterior cerebral vessel occlusions is associated with unfavorable functional outcome. Interventional studies are needed to determine the role of SBP management as a modifiable parameter in the early phase after successful EVT.

scholarly journals Role of Vascular Adaptation in Determining Systolic Blood Pressure in Young Adults

2020 ◽  
Vol 9 (7) ◽  
Author(s):  
Shikai Yu ◽  
Jessica E. Middlemiss ◽  
Chiara Nardin ◽  
Stacey S. Hickson ◽  
Karen L. Miles ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Systolic Blood Pressure ◽  
Vascular Resistance ◽  
Impaired Ability ◽  
Vessel Structure ◽  
Underlying Mechanisms ◽  
Different Levels ◽  
Forearm Vascular Resistance

Background Two individuals can have a similar pulse pressure ( PP ) but different levels of systolic blood pressure ( SBP ), although the underlying mechanisms have not been described. We hypothesized that, for a given level of PP , differences in SBP relate to peripheral vascular resistance ( PVR ); and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results Demographic, biochemical, and hemodynamic data from 3103 subjects were available for the current analyses. In both men and women, for a given level of PP , higher SBP was associated with significantly higher body weight, body mass index, heart rate, and PVR ( P <0.05 versus those with lower BP for all comparisons). Moreover, stratifying individuals by quartiles of PP and PVR revealed a stepwise increase in SBP from the lowest to highest quartile for each variable, with the highest SBP occurring in those in the highest quartile of both PP and PVR ( P <0.001 for overall trend for both sexes). PVR was also increased with increasing tertile of minimum forearm vascular resistance, in both men ( P =0.002) and women ( P =0.03). Conclusions Increased PVR , mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults. An impaired ability to adapt PVR appropriately to a given level of PP may be an important mechanism underlying elevated SBP in young adults.

The role of size at birth and postnatal catch-up growth in determining systolic blood pressure

2000 ◽  
Vol 18 (7) ◽  
pp. 815-831 ◽  
Author(s):  
Rachel R. Huxley ◽  
Alistair W. Shiell ◽  
Catherine M. Law
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Catch Up ◽  
Size At Birth

Vasopressin in the rat with spontaneous hypertension

1978 ◽  
Vol 235 (4) ◽  
pp. H361-H366 ◽  
Author(s):  
J. T. Crofton ◽  
L. Share ◽  
R. E. Shade ◽  
C. Allen ◽  
D. Tarnowski
Keyword(s):  
Blood Pressure ◽  
Urinary Excretion ◽  
Systolic Blood Pressure ◽  
Blood Volume ◽  
Rat Plasma ◽  
Wky Rats ◽  
Naturally Occurring ◽  
Plasma Vasopressin ◽  
Wistar Kyoto

Because vasopressin is one of the most potent naturally occurring pressor agents, and because of its importance in the regulation of blood volume and composition, we have undertaken a study of the role of vasopressin in the pathogenesis of the hypertension in the Okamoto-Aoki spontaneously hypertension (SH) rat. In SH rats, systolic blood pressure increased from 135 +/- 3 (SE) mmHg at age 33 days to 184 +/- 3 mmHg at age 75 days (P less than 0.01). In the Wistar-Kyoto (WKY) control rats, blood pressure increased from 100 +/- 2 to 120 +/- 2 mmHg (P less than 0.01). The differences in blood pressure between the SH and WKY rats at all ages were significant (P less than 0.01). During the age period 33-75 days, the 24-h urinary excretion of vasopressin in the SH rat was consistently more than twofold greater (P less than 0.01) than in the WKY rat. Plasma vasopressin concentration and pituitary vasopressin content were also elevated in the SH rat (P less than 0.01 and P less than 0.02, respectively). Changes in systolic blood pressure in the SH rat, however, were not paralleled by changes in the urinary excretion of vasopressin. The data indicate that the secretion of vasopressin is elevated in the SH rat. However, the magnitude of this elevation, in and of itself, may not be sufficient to account for the rising blood pressure in the young SH rat.

scholarly journals Does Compassion Predict Blood Pressure and Hypertension? The Modifying Role of Familial Risk for Hypertension

2020 ◽  
Vol 27 (5) ◽  
pp. 527-538
Author(s):  
Aino I. L. Saarinen ◽  
Liisa Keltikangas-Järvinen ◽  
Taina Hintsa ◽  
Laura Pulkki-Råback ◽  
Niklas Ravaja ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Health Behaviors ◽  
Systolic Blood Pressure ◽  
Socioeconomic Factors ◽  
Early Onset ◽  
Lower Risk ◽  
Familial Risk ◽  
Young Finns Study

Abstract Background This study investigated (i) whether compassion is associated with blood pressure or hypertension in adulthood and (ii) whether familial risk for hypertension modifies these associations. Method The participants (N = 1112–1293) came from the prospective Young Finns Study. Parental hypertension was assessed in 1983–2007; participants’ blood pressure in 2001, 2007, and 2011; hypertension in 2007 and 2011 (participants were aged 30–49 years in 2007–2011); and compassion in 2001. Results High compassion predicted lower levels of diastolic and systolic blood pressure in adulthood. Additionally, high compassion was related to lower risk for hypertension in adulthood among individuals with no familial risk for hypertension (independently of age, sex, participants’ and their parents’ socioeconomic factors, and participants’ health behaviors). Compassion was not related to hypertension in adulthood among individuals with familial risk for hypertension. Conclusion High compassion predicts lower diastolic and systolic blood pressure in adulthood. Moreover, high compassion may protect against hypertension among individuals without familial risk for hypertension. As our sample consisted of comparatively young participants, our findings provide novel implications for especially early-onset hypertension.

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