scholarly journals Rhabdomyolysis in the Setting of Induced Hypothyroidism and Statin Therapy: A Case Report

2015 ◽  
Vol 4 (1) ◽  
pp. 62-64 ◽  
Author(s):  
Yaser Jbara ◽  
Dean Bricker

Mild elevation of creatine kinase (CK) is common in untreated hypothyroidism, but severe myositis and overt rhabdomyolysis are rare. Similarly, muscle pain and CK elevation are potential side effects of statin therapy, yet rhabdomyolysis is likewise rare in the absence of medication interactions adversely affecting statin metabolism. The coexistence of statin therapy and hypothyroid states may synergistically increase the risk of myopathy. We describe a case of rhabdomyolysis attributable to induced hypothyroidism in a patient on chronic statin medication who was anticipating adjuvant radioiodine (131I) therapy for a thyroid carcinoma

2016 ◽  
Vol 23 (2) ◽  
pp. 148-151 ◽  
Author(s):  
Donald C Moore ◽  
Andrew Moore

Abiraterone is an inhibitor of androgen biosynthesis indicated for the treatment of metastatic castration-resistant prostate cancer. Common side effects include diarrhea, edema, hypokalemia, hypertension, and liver function test abnormalities. We report a case of rhabdomyolysis developing in association with the use of abiraterone. Following discontinuation of abiraterone, creatine kinase concentrations decreased gradually throughout the duration of the hospitalization.


2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Dionise Ysabelle Vellon Bawal ◽  
Maria Honolina Sero Gomez

Abstract We report a case of a 57-year-old woman who developed severe musculoskeletal pain after taking one dose of Alendronate 70mg for treatment of osteoporosis. The pain was so debilitating that the patient was unable to sit up, stand, or move without assistance, and any kind of movement aggravated the pain. Key words: bisphosphonate, severe muscle pain, case report, osteoporosis Methods A detailed case report is presented. A review of the current literature on the side effects of bisphosphonates was made for reference. Results Development of severe, disabling musculoskeletal pain was noted after taking one dose of Alendronate 70 mg tablet. The pain was severe enough to hinder the patient from sitting or standing up, and any form of movement seemed to worsen the pain. Discontinuation of the drug, pain relievers and complete bed rest afforded slight relief of symptoms. Complete resolution of pain only occurred after 72 hours. Review of literature showed that muscle pain with intake of bisphosphonates occurred in a few patients, and were mostly found in case reports or case series. Other commonly associated side effects with bisphosphonate therapy were also briefly discussed. Conclusion The case presented emphasizes that bisphosphonate therapy, although frequently used uneventfullyn, may still produce adverse effects in a few patients. A handful may present with severe debilitating muscle pain as seen in our patient. Literature review showed that another subset of patients may react differently and present with cardiac or ocular symptoms. What must be taken from this paper is the importance of patient education regarding these possible adverse events that although infrequent, may still happen. These unpleasant adverse effects may greatly affect compliance and ultimately have a bigger impact in the fight against osteoporosis.


2019 ◽  
Author(s):  
BA Högerle ◽  
EL Bulut ◽  
L Klotz ◽  
F Eichhorn ◽  
M Eichhorn ◽  
...  

Author(s):  
Beliz Camur ◽  
Mehmet Celik ◽  
Buket Yilmaz Bulbul ◽  
Semra Ayturk ◽  
Ebru Tastekin ◽  
...  

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