scholarly journals MicroRNA-302b Suppresses Human Epithelial Ovarian Cancer Cell Growth by Targeting RUNX1

2014 ◽  
Vol 34 (6) ◽  
pp. 2209-2220 ◽  
Author(s):  
Tingting Ge ◽  
Mingzhu Yin ◽  
Meng Yang ◽  
Tianbo Liu ◽  
Ge Lou
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Epithelial Ovarian Cancer Cell ◽  
Cancer Cell Growth

Inhibition of Human Epithelial Ovarian Cancer Cell Growth in vitro by Somatostatin Analog RC-160

Oncology ◽  
2000 ◽  
Vol 59 (Suppl. 1) ◽  
pp. 45-49 ◽  
Author(s):  
Tetsu Yano ◽  
Sinisa Radulovic ◽  
Yutaka Osuga ◽  
Koji Kugu ◽  
Hiroyuki Yoshikawa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Somatostatin Analog ◽  
Epithelial Ovarian Cancer Cell ◽  
Cancer Cell Growth

MUC16 (CA125) regulates epithelial ovarian cancer cell growth, tumorigenesis and metastasis

2011 ◽  
Vol 121 (3) ◽  
pp. 434-443 ◽  
Author(s):  
Catherine Thériault ◽  
Maxime Pinard ◽  
Marina Comamala ◽  
Martine Migneault ◽  
Julie Beaudin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Epithelial Ovarian Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2061
Author(s):  
Cecilia Pozzi ◽  
Matteo Santucci ◽  
Gaetano Marverti ◽  
Domenico D’Arca ◽  
Lorenzo Tagliazucchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Thymidylate Synthase ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cells ◽  
Preclinical Research ◽  
Cancer Cell Growth ◽  
X Ray ◽  
Synergistic Inhibition

Combining drugs represent an approach to efficiently prevent and overcome drug resistance and to reduce toxicity; yet it is a highly challenging task, particularly if combinations of inhibitors of the same enzyme target are considered. To show that crystallographic and inhibition kinetic information can provide indicators of cancer cell growth inhibition by combinations of two anti-human thymidylate synthase (hTS) drugs, we obtained the X-ray crystal structure of the hTS:raltitrexed:5-fluorodeoxyuridine monophosphate (FdUMP) complex. Its analysis showed a ternary complex with both molecules strongly bound inside the enzyme catalytic cavity. The synergistic inhibition of hTS and its mechanistic rationale were consistent with the structural analysis. When administered in combination to A2780 and A2780/CP ovarian cancer cells, the two drugs inhibited ovarian cancer cell growth additively/synergistically. Together, these results support the idea that X-ray crystallography can provide structural indicators for designing combinations of hTS (or any other target)-directed drugs to accelerate preclinical research for therapeutic application.

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