scholarly journals 4-1BB and the Epigenetic Regulations of This Molecule

2014 ◽  
Vol 2 (3) ◽  
pp. 80-85 ◽  
Author(s):  
Thien Chu-Dinh ◽  
Dinh-Toi Chu
Keyword(s):  
Epigenetic Regulations

scholarly journals Targeting epigenetic regulations in cancer

2015 ◽  
pp. gmv116 ◽  
Author(s):  
Bo Ning ◽  
Wenyuan Li ◽  
Wei Zhao ◽  
Rongfu Wang
Keyword(s):  
Epigenetic Regulations

Immunotherapeutics for AD: A Work in Progress

2021 ◽  
Vol 20 ◽  
Author(s):  
Anuja Sharma ◽  
Jaspreet Singh Anand ◽  
Yatender Kumar
Keyword(s):  
Tau Protein ◽  
Therapeutic Strategy ◽  
Neurodegenerative Disorder ◽  
Disease Onset ◽  
Amyloid Β ◽  
Therapeutic Strategies ◽  
Genetic Defects ◽  
Multiple Factors ◽  
Neurodegenerative Process ◽  
Epigenetic Regulations

: Alzheimer's Disease (AD), often called the 'Plague of the 21st Century,' is a progressive, irreversible neurodegenerative disorder that leads to the degeneration and death of neurons. Multiple factors, such as genetic defects, epigenetic regulations, environmental factors, or cerebrovascular damage, are a manifestation of the neurodegenerative process that begins to occur decades before the onset of disease. To date, no treatment or therapeutic strategy has proven to be potent in inhibiting its progress or reversing the effects of the disease. The ever-increasing numbers and lack of sufficient therapies that can control or reverse the effects of the disease have propelled research in the direction of devising efficient therapeutic strategies for AD. This review comprehensively discusses the active and passive immunotherapies against Amyloid-β and Tau protein, which remain the popular choice of targets for AD therapeutics. Some of the prospective immunotherapies against Aβ plaques have failed due to various reasons. Much of the research is focused on targeting Tau, specifically, targeting the mid-region of extracellular Tau due to their potential to prevent seeding and hence the spread of neurofibrillary tangles (NFTs). Thus, there is a need to thoroughly understand the disease onset mechanisms and discover effective therapeutic strategies.

scholarly journals Hypoxia in Cell Reprogramming and the Epigenetic Regulations

2021 ◽  
Vol 9 ◽  
Author(s):  
Nariaki Nakamura ◽  
Xiaobing Shi ◽  
Radbod Darabi ◽  
Yong Li
Keyword(s):  
Cell Proliferation ◽  
Cell Fate ◽  
Tissue Regeneration ◽  
Cellular Reprogramming ◽  
Cell Reprogramming ◽  
Cell Renewal ◽  
Cellular Functions ◽  
Stem Cell Renewal ◽  
Epigenetic Regulations

Cellular reprogramming is a fundamental topic in the research of stem cells and molecular biology. It is widely investigated and its understanding is crucial for learning about different aspects of development such as cell proliferation, determination of cell fate and stem cell renewal. Other factors involved during development include hypoxia and epigenetics, which play major roles in the development of tissues and organs. This review will discuss the involvement of hypoxia and epigenetics in the regulation of cellular reprogramming and how interplay between each factor can contribute to different cellular functions as well as tissue regeneration.

scholarly journals Dietary vinegar prevents kidney stone recurrence via epigenetic regulations

EBioMedicine ◽  
2019 ◽  
Vol 45 ◽  
pp. 231-250 ◽  
Author(s):  
Wei Zhu ◽  
Yang Liu ◽  
Yu Lan ◽  
Xiaohang Li ◽  
Lianmin Luo ◽  
...  
Keyword(s):  
Kidney Stone ◽  
Stone Recurrence ◽  
Epigenetic Regulations
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