Effects of the Estrous Cycle and Ovarian Hormones on Central Expression of Interleukin-1 Evoked by Stress in Female Rats

2014 ◽  
Vol 100 (2-3) ◽  
pp. 162-177 ◽  
Author(s):  
Keiko Arakawa ◽  
Hiroyuki Arakawa ◽  
Cara M. Hueston ◽  
Terrence Deak
Keyword(s):  
Estrous Cycle ◽  
Interleukin 1 ◽  
Ovarian Hormones ◽  
Female Rats

scholarly journals Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells

Cephalalgia ◽  
2012 ◽  
Vol 32 (12) ◽  
pp. 924-931 ◽  
Author(s):  
Tanner Boes ◽  
Dan Levy
Keyword(s):  
Mast Cells ◽  
Estrous Cycle ◽  
Potential Role ◽  
Ovarian Hormones ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Migraine Headaches ◽  
Male And Female Rats ◽  
Quantitative Analyses

Background: The frequency of migraine headaches is higher in women than in men and in susceptible women attacks are related to changes in ovarian hormone levels. Intracranial mast cells (MCs) are likely to have a role in migraine headache genesis, and changes in the dural MC population might influence headache susceptibility. The present study thus tested the hypothesis that sex and ovarian hormones influence the density and phenotypic makeup of dural MCs. Methods: Histochemistry combined with quantitative analyses was used to investigate sex differences, estrous cycle and ovarian hormones on dural MC density, phenotype and degranulation level in male and female rats. Results: Our data show that in female rats, dural MC density fluctuates during the estrous cycle and is overall higher than in males. In ovariectomized rats, estradiol, but not progesterone, promoted an increase in dural MC density. This effect was abolished by a splenectomy, suggesting estrogen-related recruitment of MCs from the spleen. Finally, our data suggest that the phenotypic make up of dural MCs, which represents the level of cellular maturity, is also governed by changes in estrogen levels. Conclusions: Given the potential role of dural MCs in triggering headache, our data suggest that estrogen-related modulation of dural MC density and phenotypic makeup could have a role in mediating the higher frequency and severity of headaches such as migraine, in women.

scholarly journals Effects of the estrous cycle and ovarian hormones on cue-triggered motivation and intrinsic excitability of medium spiny neurons in the Nucleus Accumbens of female rats

2019 ◽  
Author(s):  
Yanaira Alonso-Caraballo ◽  
Carrie R. Ferrario
Keyword(s):  
Food Intake ◽  
Estrous Cycle ◽  
Ovarian Hormones ◽  
Female Rats ◽  
Intrinsic Excitability ◽  
Sprague Dawley ◽  
Food Cues ◽  
Approach Behavior ◽  
Individual Susceptibility ◽  
Conditioned Approach

AbstractNaturally occurring alterations in estradiol influence food intake in females. However, how motivational responses to food cues are affected by the estrous cycle or ovarian hormones is unknown. In addition, while individual susceptibility to obesity is accompanied by enhanced incentive motivational responses to food cues and increased NAc intrinsic excitability in males, studies in females are absent. Here, we examined basal differences in intrinsic NAc excitability of obesity-prone vs. obesity-resistant females and determined how conditioned approach (a measure of cue-triggered motivation), food intake, and motivation for food vary with the cycle in naturally cycling female obesity-prone, obesity-resistant, and outbred Sprague-Dawley rats. Finally, we used ovariectomy followed by hormone treatment to determine the role of ovarian hormones in cue-triggered motivation in selectively-bred and outbred female rats. We found that intrinsic excitability of NAc MSNs and conditioned approach are enhanced in female obesity-prone vs. obesity-resistant rats. These effects were driven by greater MSN excitability and conditioned approach behavior during metestrus/diestrus vs. proestrus/estrus in obesity-prone but not obesity-resistant rats, despite similar regulation of food intake and food motivation by the cycle in these groups. Furthermore, estradiol and progesterone treatment reduced conditioned approach behavior in obesity-prone and outbred Sprague-Dawley females. To our knowledge, these data are the first to demonstrate cycle- and hormone-dependent effects on the motivational response to a food cue, and the only studies to date to determine how individual susceptibility to obesity influences NAc excitability, cue-triggered food-seeking, and differences in the regulation of these neurobehavioral responses by the cycle.

Effects of the estrous cycle and ovarian hormones on behavioral indices of anxiety in female rats

1996 ◽  
Vol 21 (7) ◽  
pp. 609-620 ◽  
Author(s):  
Sergio Mora ◽  
Nelson Dussaubat ◽  
Gabriela Díaz-Véliz
Keyword(s):  
Estrous Cycle ◽  
Ovarian Hormones ◽  
Female Rats ◽  
Behavioral Indices

scholarly journals About ovarian hormones, the effect of the corpus luteum on the estrous cycle. Cotte et Pallott (Comp. Rend. Soc. De biol 99, 69, 1928)

1929 ◽  
Vol 25 (10) ◽  
pp. 1111-1111
Keyword(s):  
Corpus Luteum ◽  
Estrous Cycle ◽  
Ovarian Hormones ◽  
Female Rats

Cotte et Pallott (Comp. Rend. Soc. De biol 99, 69, 1928) human corpuscles were transplanted into female rats. Some of the rats were castrated, and some were normal.

Shifts in preferred learning strategy across the estrous cycle in female rats

2004 ◽  
Vol 45 (5) ◽  
pp. 330-338 ◽  
Author(s):  
Donna L Korol ◽  
Emily L Malin ◽  
Kristine A Borden ◽  
Rachel A Busby ◽  
Julia Couper-Leo
Keyword(s):  
Estrous Cycle ◽  
Learning Strategy ◽  
Female Rats

scholarly journals Progesterone after Estradiol Modulates Shuttle-Cage Escape by Facilitating Volition

2015 ◽  
Vol 9s1 ◽  
pp. JEN.S32735
Author(s):  
Darryl J. Mayeaux ◽  
Sarah M. Tandle ◽  
Sean M. Cilano ◽  
Matthew J. Fitzharris
Keyword(s):  
Depressive Symptoms ◽  
Animal Models ◽  
Electric Shock ◽  
Ovarian Hormones ◽  
Learning Task ◽  
The Other ◽  
Female Rats ◽  
Animal Models Of Depression ◽  
Escape Learning

In animal models of depression, depression is defined as performance on a learning task. That task is typically escaping a mild electric shock in a shuttle cage by moving from one side of the cage to the other. Ovarian hormones influence learning in other kinds of tasks, and these hormones are associated with depressive symptoms in humans. The role of these hormones in shuttle-cage escape learning, however, is less clear. This study manipulated estradiol and progesterone in ovariectomized female rats to examine their performance in shuttle-cage escape learning without intentionally inducing a depressive-like state. Progesterone, not estradiol, within four hours of testing affected latencies to escape. The improvement produced by progesterone was in the decision to act, not in the speed of learning or speed of escaping. This parallels depression in humans in that depressed people are slower in volition, in their decisions to take action.

The anorectic effect of fenfluramine is influenced by sex and stage of the estrous cycle in rats

2005 ◽  
Vol 288 (6) ◽  
pp. R1486-R1491 ◽  
Author(s):  
Lisa A. Eckel ◽  
Heidi M. Rivera ◽  
Deann P. D. Atchley
Keyword(s):  
Food Intake ◽  
Estrous Cycle ◽  
Female Rats ◽  
Male Rats ◽  
Gonadal Hormone ◽  
Estrous Female ◽  
Male And Female Rats ◽  
Daily Food ◽  
Hormone Status ◽  
Anorectic Effect

The controls of food intake differ in male and female rats. Daily food intake is typically greater in male rats, relative to female rats, and a decrease in food intake, coincident with the estrous stage of the ovarian reproductive cycle, is well documented in female rats. This estrous-related decrease in food intake has been attributed to a transient increase in the female rat's sensitivity to satiety signals generated during feeding bouts. Here, we investigated whether sex or stage of the estrous cycle modulate the satiety signal generated by fenfluramine, a potent serotonin (5-HT) releasing agent. To examine this hypothesis, food intake was monitored in male, diestrous female, and estrous female rats after intraperitoneal injections of 0, 0.25, and 1.0 mg/kg d-fenfluramine. The lower dose of fenfluramine decreased food intake only in diestrous and estrous females, suggesting that the minimally effective anorectic dose of fenfluramine is lower in female rats, relative to male rats. Although the larger dose of fenfluramine decreased food intake in both sexes, the duration of anorexia was greater in diestrous and estrous female rats, relative to male rats. Moreover, the magnitude of the anorectic effect of the larger dose of fenfluramine was greatest in estrous rats, intermediate in diestrous rats, and least in male rats. Thus our findings indicate that the anorectic effect of fenfluramine is modulated by gonadal hormone status.

Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones

2015 ◽  
Vol 232 (20) ◽  
pp. 3773-3782 ◽  
Author(s):  
Firas Sedki ◽  
James Gardner Gregory ◽  
Adriana Luminare ◽  
Tracey M. D’Cunha ◽  
Uri Shalev
Keyword(s):  
Food Restriction ◽  
Ovarian Hormones ◽  
Female Rats
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