T Helper 17 Cells and Related Cytokines after Allergen Inhalation Challenge in Allergic Asthmatics

2014 ◽  
Vol 165 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Nizar Naji ◽  
Steven G. Smith ◽  
Gail M. Gauvreau ◽  
Paul M. O'Byrne
Keyword(s):  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Allergen Inhalation ◽  
Inhalation Challenge ◽  
Allergen Inhalation Challenge

Assessment of the role of T Helper 17 cells in the pathogenesis of Acne Vulgaris

2019 ◽  
Vol 10 (12) ◽  
pp. 1435
Author(s):  
Nahla Maher ◽  
HebatAllah Ismail Gawdat ◽  
Heba Helmy El Hadidi ◽  
Olfat Gamil Shaker
Keyword(s):  
Acne Vulgaris ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells

scholarly journals Allergen-induced airway responses

2015 ◽  
Vol 46 (3) ◽  
pp. 819-831 ◽  
Author(s):  
Gail M. Gauvreau ◽  
Amani I. El-Gammal ◽  
Paul M. O'Byrne
Keyword(s):  
Early Response ◽  
Myeloid Dendritic Cells ◽  
Clinical Model ◽  
Allergen Inhalation ◽  
Chemotactic Factors ◽  
Inhalation Challenge ◽  
Airway Responses ◽  
Neutral Proteases ◽  
Allergen Inhalation Challenge

Environmental allergens are an important cause of asthma and can contribute to loss of asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical model to examine the mechanisms of allergen-induced airway responses and inflammation. Allergen bronchoconstrictor responses are the early response, which reaches a maximum within 30 min and resolves by 1–3 h, and late responses, when bronchoconstriction recurs after 3–4 h and reaches a maximum over 6–12 h. Late responses are followed by an increase in airway hyperresponsiveness. These responses occur when IgE on mast cells is cross-linked by an allergen, causing degranulation and the release of histamine, neutral proteases and chemotactic factors, and the production of newly formed mediators, such as cysteinyl leukotrienes and prostaglandin D2. Allergen-induced airway inflammation consists of an increase in airway eosinophils, basophils and, less consistently, neutrophils. These responses are mediated by the trafficking and activation of myeloid dendritic cells into the airways, probably as a result of the release of epithelial cell-derived thymic stromal lymphopoietin, and the release of pro-inflammatory cytokines from type 2 helper T-cells. Allergen inhalation challenge has also been a widely used model to study potential new therapies for asthma and has an excellent negative predictive value for this purpose.

T helper 17 cells: discovery, function, and physiological trigger

2010 ◽  
Vol 67 (9) ◽  
pp. 1407-1421 ◽  
Author(s):  
Miriam Beer Torchinsky ◽  
J. Magarian Blander
Keyword(s):  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells

T-helper 17 cells: The driving force of psoriasis and psoriatic arthritis

2012 ◽  
Vol 15 (6) ◽  
pp. 531-537 ◽  
Author(s):  
In Seol Yoo ◽  
Jeung Hoon Lee ◽  
Seung Tak Song ◽  
Jin Hyun Kim ◽  
Hyun Ji Lee ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Driving Force ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells
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