EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations

2014 ◽  
Vol 48 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Leilei Zheng ◽  
Hao Chai ◽  
Shaohua Yu ◽  
You Xu ◽  
Wanzhen Chen ◽  
...  
Keyword(s):  
Paranoid Schizophrenia ◽  
Auditory Hallucinations ◽  
First Episode ◽  
Theta Power ◽  
Octave Illusion

Electroconvulsive Therapy in Treatment-Resistant Schizophrenia: a Case Report

2011 ◽  
Vol 26 (S2) ◽  
pp. 1135-1135
Author(s):  
V.M. Barrau ◽  
M. Salinas ◽  
S. Yelmo ◽  
E. Santana ◽  
F. Montiano ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Hospital Admissions ◽  
Paranoid Schizophrenia ◽  
Chronic Schizophrenia ◽  
Optimal Number ◽  
Auditory Hallucinations ◽  
Predictors Of Response ◽  
Maintenance Ect ◽  
Controversial Topic ◽  
Null Response

Electroconvulsive therapy (ECT) is born as we know it in the first half of the twentieth century. Although initially introduced as a treatment for schizophrenia, soon proved more effective in affective disorders.Currently this therapy is second choice in the treatment of schizophrenia, representing only 10–20% of ECT treatments.We present a 55 years-old-woman diagnosed with Paranoid Schizophrenia in the adolescence, with several hospital admissions who was sent from sub-acute unit to receive ECT, given the null response to several pharmacological trials. The last, 1,200 mg amisulpride, 650 mg clozapine and 1,000 mg valproate per day, and Zuclopenthixol ampoule every 14 days. She verbalizes poorly structured persecutory, megalomaniac and nihilist delusional ideas, as well as auditory hallucinations which she does not clarify, and thought broadcasting phenomena. After withdrawing this medication and starting treatment with 30 mg haloperidol and 550 mg quetiapine, 14 bifrontotemporal ECT sessions were given.Given the disappearance of persecutory delusional ideas, and the decrease of auditory hallucinations, which she criticizes, the patient was discharged. After 4 months, she is still psychopathologically stable, and receiving maintenance ECT biweekly.ECT, either alone or in combination with conventional antipsychotic drugs, has been shown effective in a certain percentage of patients with acute schizophrenia, particularly in the catatonic subtype and also in schizoaffective disorder. The use and efficacy of ECT in chronic schizophrenia is a more controversial topic.Research should also focus on the determination of optimal number of ECT, the predictors of response and the efficacy of continuation and maintenance ECT.

Altered corticostriatal pathway in first-episode paranoid schizophrenia: Resting-state functional and causal connectivity analyses

2018 ◽  
Vol 272 ◽  
pp. 38-45 ◽  
Author(s):  
Huan Huang ◽  
Chang Shu ◽  
Jun Chen ◽  
Jilin Zou ◽  
Cheng Chen ◽  
...  
Keyword(s):  
Resting State ◽  
Paranoid Schizophrenia ◽  
First Episode

scholarly journals White Matter Microstructural Abnormalities in the Broca’s-Wernicke’s-Putamen “Hoffman Hallucination Circuit” and Auditory Transcallosal Fibers in First-Episode Psychosis With Auditory Hallucinations

2020 ◽  
Author(s):  
Dean F Salisbury ◽  
Yiming Wang ◽  
Fang-Cheng Yeh ◽  
Brian A Coffman
Keyword(s):  
White Matter ◽  
Left Hemisphere ◽  
Structural Integrity ◽  
Right Hemisphere ◽  
First Episode Psychosis ◽  
Auditory Hallucinations ◽  
First Episode ◽  
Psychotic Episode ◽  
Arcuate Fasciculus ◽  
Episode Psychosis

Abstract Background Functional connectivity abnormalities between Broca’s and Wernicke’s areas and the putamen revealed by functional magnetic resonance imaging (fMRI) are related to auditory hallucinations (AH). In long-term schizophrenia, reduced white matter structural integrity revealed by diffusion imaging in left arcuate fasciculus (connecting Broca’s and Wernicke’s areas) is likely related to AH. The structural integrity of connections with putamen and their relation to AH are unknown. Little is known about this relationship in first-episode psychosis (FEP), although auditory transcallosal connections were reported to play a role. White matter in the Broca’s-Wernicke’s-putamen language-related circuit and auditory transcallosal fibers was examined to investigate associations with AH in FEP. Methods White matter connectivity was measured in 40 FEP and 32 matched HC using generalized fractional anisotropy (gFA) derived from diffusion spectrum imaging (DSI). Results FEP and HC did not differ in gFA in any fiber bundle. In FEP, AH severity was significantly inversely related to gFA in auditory transcallosal fibers and left arcuate fasciculus. Although the right hemisphere arcuate fasciculus-AH association did not attain significance, the left and right arcuate fasciculus associations were not significantly different. Conclusions Despite overall normal gFA in FEP, AH severity was significantly related to gFA in transcallosal auditory fibers and the left hemisphere connection between Broca’s and Wernicke’s areas. Other bilateral tracts’ gFA were weakly associated with AH. At the first psychotic episode, AH are more robustly associated with left hemisphere arcuate fasciculus and interhemispheric auditory fibers microstructural deficits, likely reflecting mistiming of information flow between language-related cortical centers.

scholarly journals Cognitive Restructuring and Graded Behavioural Exposure for Delusional Appraisals of Auditory Hallucinations and Comorbid Anxiety in Paranoid Schizophrenia

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Pawel D. Mankiewicz ◽  
Colin Turner
Keyword(s):  
Psychosocial Functioning ◽  
Psychological Treatment ◽  
Paranoid Schizophrenia ◽  
Cognitive Restructuring ◽  
Behavioural Therapy ◽  
Auditory Hallucinations ◽  
Successful Implementation ◽  
Subjective Data ◽  
Comorbid Anxiety ◽  
Behavioural Experiments

The prevalence of diagnostic comorbidity between psychosis and anxiety disorders has been found to be considerable. Cognitive models of psychosis suggest that anxiety does not arise directly from positive symptoms of schizophrenia but rather from an individual interpretation of such experiences. In the United Kingdom, cognitive-behavioural therapy for psychosis (CBTp) has been recommended within clinical guidelines as a psychological treatment of choice for those diagnosed with schizophrenia. However, despite empirical evidence supporting CBTp, the treatment provision remains infrequent and not routinely available. This case describes a successful implementation of CBTp. Sixteen sessions were delivered to a 40-year-old male with diagnoses of paranoid schizophrenia and comorbid anxiety, focusing primarily on cognitive restructuring of paranoid appraisals of auditory hallucinations and behavioural experiments employed progressively via graded exposure to anxiety-inducing stimuli. Standardised measurements, behavioural frequency sampling, and subjective data indicated a considerable reduction in both paranoia and anxiety. Also, the client’s psychosocial functioning improved substantially. This report indicates that the treatment may help those with experiences of psychosis and comorbid anxiety reach a significant improvement in their quality of life and offers an encouraging and innovative perspective on direct engagement with the content of paranoia and voices at the onset of therapy.

An Unusual Foreign Body Ingestion in a Schizophrenic Patient: Case Report

2005 ◽  
Vol 35 (3) ◽  
pp. 313-318 ◽  
Author(s):  
Benjamin Abraham ◽  
Adekola O. Alao
Keyword(s):  
Foreign Body ◽  
Foreign Bodies ◽  
Paranoid Schizophrenia ◽  
Auditory Hallucinations ◽  
Foreign Body Ingestion ◽  
Patient Case ◽  
Unusual Foreign Body ◽  
Treatment And Prevention ◽  
Intentional Ingestion ◽  
Extensive Coverage

The topic of foreign body ingestion has received extensive coverage in the areas of surgery, emergency medicine, and pediatrics. A subset of this topic, the intentional ingestion of foreign bodies, however, is much less common, and requires special evaluation and management. Here, we report a case of ingestion of a rolled, metal tuna can lid in a male prison inmate previously diagnosed with depression and paranoid schizophrenia. Following evaluation by the surgical team, the foreign body was removed by laparotomy and the patient was discharged back to the prison without complication. In many cases, ingestions of this type involve a command hallucination ordering the patient to swallow the foreign body. Interestingly, the patient in the present case reported auditory hallucinations commanding him not to swallow the can lid. On further investigation, we found that patient had a proclivity toward this swallowing behavior even prior to his incarceration. Early identification of inmates with this proclivity has important implications for treatment and prevention.

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