Protective Effects of Relaxin against Cisplatin-Induced Nephrotoxicity in Rats

2014 ◽  
Vol 128 (1-2) ◽  
pp. 9-20 ◽  
Author(s):  
Takuya Yoshida ◽  
Hiromichi Kumagai ◽  
Tetsuya Kohsaka ◽  
Naoki Ikegaya
Keyword(s):  
Protective Effects

Melatonin reduces high levels of lipid peroxidation induced by potassium iodate in porcine thyroid

2019 ◽  
pp. 1-7 ◽  
Author(s):  
Paulina Iwan ◽  
Jan Stepniak ◽  
Malgorzata Karbownik-Lewinska
Keyword(s):  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Membrane Lipids ◽  
Chemical Properties ◽  
Iodine Concentration ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Potassium Iodate ◽  
Hormone Synthesis

Abstract. Iodine is essential for thyroid hormone synthesis. Under normal iodine supply, calculated physiological iodine concentration in the thyroid is approx. 9 mM. Either potassium iodide (KI) or potassium iodate (KIO3) are used in iodine prophylaxis. KI is confirmed as absolutely safe. KIO3 possesses chemical properties suggesting its potential toxicity. Melatonin (N-acetyl-5-methoxytryptamine) is an effective antioxidant and free radical scavenger. Study aims: to evaluate potential protective effects of melatonin against oxidative damage to membrane lipids (lipid peroxidation, LPO) induced by KI or KIO3 in porcine thyroid. Homogenates of twenty four (24) thyroids were incubated in presence of either KI or KIO3 without/with melatonin (5 mM). As melatonin was not effective against KI-induced LPO, in the next step only KIO3 was used. Homogenates were incubated in presence of KIO3 (200; 100; 50; 25; 20; 15; 10; 7.5; 5.0; 2.5; 1.25 mM) without/with melatonin or 17ß-estradiol. Five experiments were performed with different concentrations of melatonin (5.0; 2.5; 1.25; 1.0; 0.625 mM) and one with 17ß-estradiol (1.0 mM). Malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA) concentration (LPO index) was measured spectrophotometrically. KIO3 increased LPO with the strongest damaging effect (MDA + 4-HDA level: ≈1.28 nmol/mg protein, p < 0.05) revealed at concentrations of around 15 mM, thus corresponding to physiological iodine concentrations in the thyroid. Melatonin reduced LPO (MDA + 4-HDA levels: from ≈0.97 to ≈0,76 and from ≈0,64 to ≈0,49 nmol/mg protein, p < 0.05) induced by KIO3 at concentrations of 10 mM or 7.5 mM. Conclusion: Melatonin can reduce very strong oxidative damage to membrane lipids caused by KIO3 used in doses resulting in physiological iodine concentrations in the thyroid.

Protective Effects of Self-Forgiveness on Alcohol Abuse Depend on Severity of Shame

2009 ◽  
Author(s):  
Phillip A. Ianni ◽  
Kenneth E. Hart ◽  
Stephen Hibbard ◽  
Michelle Carroll ◽  
Tobi Wilson ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Protective Effects ◽  
Self Forgiveness

Protective Effects of Sense of Community and Ethnic Identity among Urban Adolescents from Diverse Ethnocultural Groups

2009 ◽  
Author(s):  
Pauline Garcia-Reid ◽  
Christina Hamme Peterson ◽  
Robert James Reid ◽  
Paul W. Speer ◽  
N. Andrew Peterson
Keyword(s):  
Ethnic Identity ◽  
Sense Of Community ◽  
Urban Adolescents ◽  
Protective Effects ◽  
Ethnocultural Groups

Protective effects of dietary phytoestrogens in chronic renal disease

2001 ◽  
Vol 11 (4) ◽  
pp. 183-193 ◽  
Author(s):  
Tedine Ranich ◽  
Sam J. Bhathena ◽  
Manuel T. Velasquez
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Protective Effects

Anti-Inflammatory and Barrier-Protective Effects of Berberine

2011 ◽  
Vol 49 (10) ◽  
Author(s):  
Lena John ◽  
Anja Fromm ◽  
Michael Fromm ◽  
Jörg-Dieter Schulzke ◽  
Maren Amasheh
Keyword(s):  
Protective Effects ◽  
Anti Inflammatory

Protective effects of Brazilian native fruits against reactive oxygen species

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
J Infante ◽  
A Massarioli ◽  
PL Rosalen ◽  
S Alencar
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Protective Effects
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