Adenosine Triphosphate-Induced Rabbit Corneal Endothelial Cell Proliferation in vitro via the P2Y2-PI3K/Akt Signaling Axis

2014 ◽  
Vol 199 (2-3) ◽  
pp. 131-139 ◽  
Author(s):  
Junzhao Chen ◽  
Chunyi Shao ◽  
Wenjuan Lu ◽  
Chenxi Yan ◽  
Qinke Yao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Adenosine Triphosphate ◽  
Akt Signaling ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Signaling Axis ◽  
Proliferation In Vitro

Cellular redox state predicts in vitro corneal endothelial cell proliferation capacity

2006 ◽  
Vol 83 (4) ◽  
pp. 903-910 ◽  
Author(s):  
Choul Yong Park ◽  
Zejin Zhu ◽  
Cheng Zhang ◽  
Christina S. Moon ◽  
Roy S. Chuck
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Redox State ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Cellular Redox ◽  
Proliferation Capacity ◽  
Cellular Redox State

Calreticulin and Calreticulin Fragments Are Endothelial Cell Inhibitors That Suppress Tumor Growth

Blood ◽  
1999 ◽  
Vol 94 (7) ◽  
pp. 2461-2468 ◽  
Author(s):  
Sandra E. Pike ◽  
Lei Yao ◽  
Joyce Setsuda ◽  
Karen D. Jones ◽  
Barry Cherney ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Proliferation ◽  
Endothelial Cell ◽  
Tumor Growth ◽  
Angiogenesis Inhibitors ◽  
Full Length ◽  
Endothelial Cell Proliferation ◽  
Proliferation In Vitro

Several angiogenesis inhibitors are fragments of larger proteins that are themselves not active as angiogenesis inhibitors. Vasostatin, the N-terminal domain of calreticulin inclusive of amino acids 1-180, is an angiogenesis inhibitor that exerts antitumor effects in vivo. In the present study, we examined whether the full-length calreticulin molecule shares the antiangiogenic and antitumor activities of vasostatin. Similar to vasostatin, calreticulin selectively inhibited endothelial cell proliferation in vitro, but not cells of other lineages, and suppressed angiogenesis in vivo. When inoculated into athymic mice, calreticulin inhibited Burkitt tumor growth comparably with vasostatin. Calreticulin lacking the N-terminal 1-120 amino acids inhibited endothelial cell proliferation in vitro and Burkitt tumor growth in vivo comparably with vasostatin. An internal calreticulin fragment encompassing amino acids 120-180 also inhibited endothelial cell proliferation in vitro and angiogenesis in vivo comparably with calreticulin and vasostatin. These results suggest that the antiangiogenic activities of vasostatin reside in a domain that is accessible from the full-length calreticulin molecule and localize to calreticulin N-terminal amino acids 120-180. Thus, calreticulin and calreticulin fragments are inhibitors of angiogenesis that directly target endothelial cells, inhibit angiogenesis, and suppress tumor growth. This information may be critical in designing targeted inhibitors of pathological angiogenesis that underlies cancer and other diseases.

scholarly journals Augmentation by heparin of endothelial cell proliferation in vitro.

1985 ◽  
Vol 16 (5) ◽  
pp. 508-513
Author(s):  
Kohei MIYAZONO ◽  
Tetsuro OKABE ◽  
Shun ISHIBASHI ◽  
Akio URABE ◽  
Fumimaro TAKAKU
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Proliferation In Vitro

Smad7 Suppresses the Inhibitory Effect of TGF-β2 on Corneal Endothelial Cell Proliferation and Accelerates Corneal Endothelial Wound Closure In Vitro

Cornea ◽  
2003 ◽  
Vol 22 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Toshinari Funaki ◽  
Atsuhito Nakao ◽  
Nobuyuki Ebihara ◽  
Yasuhiro Setoguchi ◽  
Yoshinosuke Fukuchi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Wound Closure ◽  
Inhibitory Effect ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Proliferation

scholarly journals Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo

1999 ◽  
Vol 55 (6) ◽  
pp. 2236-2249 ◽  
Author(s):  
Christian P.M. Hugo ◽  
Raimund P. Pichler ◽  
Eckhard Schulze-Lohoff ◽  
Felicitas Pröls ◽  
Stephen Adler ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Glomerular Endothelial Cell ◽  
Proliferation In Vitro
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