Adjusting Hemodialysis Dose for Protein Catabolic Rate

2014 ◽  
Vol 38 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Aarne J. Vartia
Keyword(s):  
Catabolic Rate ◽  
Hemodialysis Dose ◽  
Protein Catabolic Rate

Routine Evaluation of Kt/V and Protein Catabolic Rate

1989 ◽  
pp. 337-339 ◽  
Author(s):  
F. G. Casino ◽  
V. Gaudiano ◽  
A. Sacco ◽  
T. Lopez
Keyword(s):  
Catabolic Rate ◽  
Protein Catabolic Rate

scholarly journals Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial

2019 ◽  
Author(s):  
Mohamed Belmouaz ◽  
Marc Bauwens ◽  
Thierry Hauet ◽  
Valentin Bossard ◽  
Pierre Jamet ◽  
...  
Keyword(s):  
Fibroblast Growth Factor 23 ◽  
High Flux ◽  
Catabolic Rate ◽  
Middle Molecules ◽  
Secondary Endpoints ◽  
Potential Benefits ◽  
To Receive ◽  
And Oxidative Stress ◽  
Protein Catabolic Rate

Abstract Background Accumulation of middle-weight uraemic toxins in haemodialysis (HD) patients results in increased morbidity and mortality. Whether medium cut-off HD (MCO-HD) improves removal of middle-weight uraemic toxins remains to be demonstrated. Methods This cross-over prospective study included 40 patients randomly assigned to receive either 3 months of MCO-HD followed by 3 months of high-flux HD (HF-HD), or vice versa. The primary endpoint was myoglobin reduction ratio (RR) after 3 months of MCO-HD. Secondary endpoints were the effect of MCO-HD on other middle-weight toxins and protein-bound toxins, and on parameters of nutrition, inflammation, anaemia and oxidative stress. Results Compared with HF-HD, MCO-HD provided higher mean RR of myoglobin (36 ± 8 versus 57 ± 13%, P < 0.0001), beta2-microglobulin (68 ± 6 versus 73 ± 15%, P = 0.04), prolactin (32 ± 13 versus 59 ± 11%, P < 0.0001), fibroblast growth factor 23 (20 ± 21 versus 41 ± 22%, P = 0.0002), homocysteine (43 ± 7 versus 46 ± 9%, P = 0.03) and higher median RR of kappa [54 (48–58) versus 70 (63–74)%, P < 0.0001] and lambda free light chain (FLC) [15 (9–22) versus 44 (38–49)%, P < 0.0001]. Mean ± SD pre-dialysis levels of beta2-microglobulin (28.4 ± 5.6 versus 26.9 ± 5.1 mg/L, P = 0.01) and oxidized low-density lipoprote (6.9 ± 4.4 versus 5.5 ± 2.5 pg/mL, P = 0.04), and median (interquartile range) kappa FLC [145 (104–203) versus 129 (109–190) mg/L, P < 0.03] and lambda FLC [106 (77–132) versus 89 (62–125) mg/L, P = 0.002] were significantly lower. Mean albumin levels decreased significantly (38.2 ± 4.1 versus 36.9 ± 4.3 g/L, P = 0.004), without an effect on nutritional status as suggested by unchanged normalized protein catabolic rate and transthyretin level. Conclusions Compared with HF-HD, MCO-HD provides higher myoglobin and other middle molecules RR and is associated with moderate hypoalbuminemia. The potential benefits of this strategy on long-term clinical outcomes deserve further evaluation.

Is the Correlation between the Normalised Protein Catabolic Rate (Npcr) and Kt/V the Result of Mathematical Coupling?

1994 ◽  
Vol 86 (s30) ◽  
pp. 4P-4P ◽  
Author(s):  
J.C. Harty ◽  
B Farragher ◽  
H Boulton ◽  
J Kirwell ◽  
N Heelis ◽  
...  
Keyword(s):  
Catabolic Rate ◽  
Mathematical Coupling ◽  
Protein Catabolic Rate

scholarly journals Hematologic and Biochemical Indices in the East African Baboon

Blood ◽  
1965 ◽  
Vol 26 (5) ◽  
pp. 682-686 ◽  
Author(s):  
HENRY FOY ◽  
ATHENA KONDI ◽  
VERSTISTINE MBAYA
Keyword(s):  
Serum Proteins ◽  
Human Albumin ◽  
Cell Uptake ◽  
Red Cell ◽  
East African ◽  
Catabolic Rate ◽  
Exchange Resins ◽  
Biochemical Indices ◽  
Marrow Activity ◽  
Protein Catabolic Rate

Abstract Hematologic values for peripheral blood and marrow, serum proteins, B12 and folic acid levels are given for recently caught and captive baboons (P. anubis and P.sinocephalus) in Nairobi. The hemaglobin levels were higher in captive than in wild animals. There was no change in the serum proteins unless the animals were on a riboflavindeficient diet. Marrow activity as estimated by counting red cell precursors as a percentage of the total nucleated red cell population agreed with that of red cell uptake of Fe59 ferric chloride. Hemosiderin was present in the marrow in all the animals. Protein turnover studies using I131-labeled albumin with ion exchange resins indicated that the protein catabolic rate and turnover was high. This may have been due to the selective destruction of the human albumin in the baboon.

scholarly journals Estimating total urea removal and protein catabolic rate by monitoring UV absorbance in spent dialysate

2005 ◽  
Vol 20 (11) ◽  
pp. 2458-2464 ◽  
Author(s):  
Fredrik Uhlin ◽  
Ivo Fridolin ◽  
Lars-Göran Lindberg ◽  
Martin Magnusson
Keyword(s):  
Uv Absorbance ◽  
Catabolic Rate ◽  
Spent Dialysate ◽  
Protein Catabolic Rate
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