Prenatal Diagnosis of Infantile Myofibroma with Postnatal Imaging Correlation

2014 ◽  
Vol 40 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Alan M. Coleman ◽  
Maria A. Calvo-Garcia ◽  
Andrew M. Zbojniewicz ◽  
Maria Alonso ◽  
Foong-Yen Lim
Keyword(s):  
Prenatal Diagnosis ◽  
Malignant Neoplasm ◽  
Fetal Mri ◽  
Neck Region ◽  
Perinatal Management ◽  
Prenatal Imaging ◽  
Fibrous Tumor ◽  
Infantile Myofibroma

Infantile myofibroma is the most common fibrous tumor in infancy. A majority of these lesions are solitary and occur in the head and neck region. Unless visceral sites are involved, the clinical course is typically benign. However, the difficulty in these cases is the differentiation of a benign myofibroma from a solitary malignant neoplasm and determination of visceral involvement. Prenatal diagnosis of this condition is rarely described in the literature, but it does indeed have a role in perinatal management. Our patient was initially identified by prenatal ultrasound with fetal MRI for further characterization of the mass. We present the case of a prenatally diagnosed solitary infantile myofibroma of the lower extremity and highlight the role of prenatal imaging in the diagnosis and treatment of this condition.

scholarly journals The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

2019 ◽  
Vol 10 (1) ◽  
pp. 48-53
Author(s):  
Mohammad Sowkat Hossain ◽  
S M Mahbubul Alam ◽  
Sk Md Jaynul Islam ◽  
Wasim Selimul Haque ◽  
Shamoli Yasmin
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Head And Neck Region

Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is essential especially in case of malignant tumourwhere subsequent specific therapy is required. The aim of this study was to determine the role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region. Methods: This cross-sectional study was conducted during July 2014 to June 2015. A total of 35 Bangladeshi patient’s specimens of head and neck swelling were collected from two renowned laboratories in Dhaka city.These cases were diagnosed as undifferentiated tumour in histopathological examination.Standard protocol was followed for immunohistochemistry.Then primary immunohistochemical panel which included the markers for Epithelial CK (AE1/AE3),mesenchymal marker (Vimentin) and lymphoid marker (LCA) were used.The cases which were not resolved by primary immunohistochemistry panel, the second panel was applied for further sub classification (Desmin, Chromogranin, CK20, CEA, CD20, CD30, HMB45, NSE). Based on interpretation of immunohistochemical findings final diagnoses were made.Data analysis was performed using the Statistical Package for the Social Sciences for Windows version 22.0 (SPSS, Chicago, Illinois, USA). Results: A total of 35 undifferentiated tumorsof head-neck region were studied.The mean age was 46.3±17.6 years and male to female ratio was 4.8:1. The majority 13 (37.1%) patient had cervical lymphadenopathy, 11 (31.4%) had neck mass and 4(11.4%) had in nasal/sinonasal mass.Regarding histopathologicalcell types, round cell was 21 (60.0%), spindle cell 6 (17.1%), pleomorphic cells 6(17.1%) and epithelioid cells 2(5.7%). In initial histopathological examination, majority 25(71.4%) were undifferentiated malignant neoplasm, 8(22.8%) were metastatic undifferentiated carcinoma, 1(2.9%) was pleomorphic sarcoma and the remaining 1(2.9%) had malignant adnexal tumour. By application of immunohistochemistry, most (33, 94.3%) of the cases were resolved and the two cases remained unresolved. Among the resolved cases majority (15, 45.5%) were lymphoma, 4(12.1%) were metastatic carcinoma, 3(9.1%) were Ewing’s sarcoma and malignant melanoma were found in 3(9.1%) cases. Conclusion: This study supports that the immunohistochemical technique has a fundamental role in the investigation of undifferentiated tumour origin, to determine the correct guidance for treatment and improving the prognosis for head and neck tumour patients. Birdem Med J 2020; 10(1): 48-53

scholarly journals Diagnostic Features of Myelomeningocele: The Role of Ultrafast Fetal MRI

2014 ◽  
Vol 37 (3) ◽  
pp. 219-225 ◽  
Author(s):  
David M. Mirsky ◽  
Erin S. Schwartz ◽  
Deborah M. Zarnow
Keyword(s):  
Imaging Techniques ◽  
Fetal Mri ◽  
Resonance Imaging ◽  
Fetal Magnetic Resonance Imaging ◽  
Diagnostic Features ◽  
Technical Aspects ◽  
Ultrafast Imaging ◽  
Perinatal Management ◽  
Magnetic Resonance Imaging Mri

Fetal magnetic resonance imaging (MRI) is a useful adjunct to ultrasound in the evaluation of neural tube defects. The development of ultrafast imaging techniques has contributed to the increasing clinical use of fetal MRI. This review summarizes the utility, safety and technical aspects of fetal MRI and the role it plays in the evaluation of myelomeningocele. Emphasis is placed on the benefit of fetal MRI as it pertains to presurgical planning and perinatal management.

scholarly journals A Case Report of a Solitary Fibrous Tumor of the Maxillary Sinus

Reports ◽  
2021 ◽  
Vol 4 (4) ◽  
pp. 33
Author(s):  
Mattia Di Bartolomeo ◽  
Sara Negrello ◽  
Arrigo Pellacani ◽  
Anna Maria Cesinaro ◽  
Stefano Vallone ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Maxillary Sinus ◽  
Solitary Fibrous Tumor ◽  
Malignant Neoplasm ◽  
Neck Region ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Purulent Discharge ◽  
Fibrous Tumor

A solitary fibrous tumor (SFT) is a benign neoplasm, firstly described as a mesenchymal tumor of the pleura. Its incidence range in the head and neck region is about 5–27%, but only rarely does it affect paranasal sinuses. The differential diagnosis is challenging, owing to its erosive growth pattern and immuno-histochemical features. SFTs have an aggressive behavior and an important recurrence potential. Therefore, a radical surgical excision is the gold standard therapeutic procedure. A rare SFT originating from the right maxillary sinus is reported here. The 37-year-old patient presented to the outpatient clinic with a painful expansive lesion in the whole right maxillary region. The overlying skin was inflamed and the patient had no epistaxis episodes. The 1.5 dentary element tested negative for vitality; however, a puncture of the lesion led to a hematic spill and no purulent discharge. An endoscopic-guided biopsy was suggestive either of SFT or hemangioperictoma, excluding a malignant neoplasm. A multi-equipe surgical team was activated. The lesion was embolized in order to achieve a good hemostatic control and, after 48 h, the neoplasm was radically excised with a combined open and endoscopic approach. The patient was disease-free at 12-month radiological and clinical follow-up. Given the rarity of this lesion and the delicacy required in addressing head and neck neoplasms, we believe that the present case report might be of help in further understanding how to approach cranio-facial SFTs.

scholarly journals Real-Life Diagnostic Accuracy of MRI in Prenatal Diagnosis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Manuel Recio Rodríguez ◽  
Cristina Andreu-Vázquez ◽  
Israel J. Thuissard-Vasallo ◽  
Raquel Cano Alonso ◽  
Carmina Bermejo López ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Prenatal Diagnosis ◽  
Diagnostic Accuracy ◽  
Fetal Mri ◽  
Accurate Diagnosis ◽  
Fetal Ultrasound ◽  
Additional Information ◽  
Perinatal Management ◽  
Cns Pathology

There is some controversy about the value of fetal MRI in prenatal diagnosis, and most of the studies examine its accuracy in central nervous system (CNS) pathology. The objective of this retrospective study was to assess the diagnostic accuracy and usefulness of fetal MRI in the prenatal diagnosis of central nervous system (CNS) pathology and non-CNS pathology. Patients referred to the Radiology Department between 2007 and 2018 for a fetal MRI after detection of an anomaly in the fetal ultrasound, a high-risk pregnancy, or an inconclusive fetal ultrasound (n = 623) were included in the study. Postnatal diagnosis was used to assess the diagnostic accuracy of MRI. Fetal MRI was considered to provide additional information over fetal ultrasound when findings of the fetal MRI were not detected in the fetal ultrasound or when established a pathological condition that was not detected in the fetal ultrasound. Fetal MRI provided useful information for the perinatal management and prognosis over fetal ultrasound when findings of the fetal MRI changed the postnatal prognosis, leaded to the decision to legally terminate the pregnancy, changed prenatal or postnatal follow-up, or helped in the planning of prenatal or postnatal treatment. Fetal MRI offered an accurate diagnosis in 97% of cases (compared to 90.4% of fetal ultrasound; p < 0.001 ). Concordance between fetal ultrasound and fetal MRI was 92.1%. Fetal MRI provided additional information over fetal ultrasound in 23.1% of cases. In 11.6% of cases, the information was useful for the perinatal management and prognosis. In 45 cases (7.2%), fetal MRI was the only accurate diagnosis. In conclusion, fetal MRI has a superior diagnostic accuracy, especially in CNS pathology, and provides additional useful information in CNS, thoracic, and abdominal pathology.

scholarly journals Giant Isolated Omphalocele: Role of Prenatal Diagnosis in Prognostic Asessment and Perinatal Management

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
A. M. Cubo ◽  
M. V. Lapresa Alcalde ◽  
I. Gastaca ◽  
M. O. Rodríguez-Martín ◽  
M. C. Martín Seisdedos ◽  
...  
Keyword(s):  
Case Report ◽  
Prenatal Diagnosis ◽  
Decisive Role ◽  
Pregnant Patient ◽  
First Trimester ◽  
Structural Defects ◽  
High Association ◽  
Perinatal Management ◽  
First Trimester Scan

Omphalocele is a congenital malformation of the abdominal wall consisting of a protrusion of the abdominal contents at the base of the umbilical cord. It has a high association with genetic and structural defects; however, if the latter is ruled out, its prognosis improves significantly. Prenatal diagnosis has a key role in this condition as omphalocele can be diagnosed by ultrasound in the first trimester scan, enabling a coordinated approach strategy to achieve the best perinatal results. We present a case report of a pregnant patient with a fetus having a giant omphalocele in which prenatal diagnosis played a decisive role, allowing the coordination of a multidisciplinary team, which was crucial in the immediate care of the newborn.

Prenatal imaging of amniotic band sequence: utility and role of fetal MRI as an adjunct to prenatal US

2011 ◽  
Vol 42 (5) ◽  
pp. 544-551 ◽  
Author(s):  
Jeremy Neuman ◽  
Maria A. Calvo-Garcia ◽  
Beth M. Kline-Fath ◽  
Constance Bitters ◽  
Arnold C. Merrow ◽  
...  
Keyword(s):  
Fetal Mri ◽  
Amniotic Band ◽  
Prenatal Imaging ◽  
Band Sequence ◽  
Amniotic Band Sequence

scholarly journals The role of prenatal diagnosis in the perinatal management of urinary tract abnormalities

1985 ◽  
Vol 13 (2) ◽  
pp. 79-86 ◽  
Author(s):  
L. Selvaggi ◽  
G. Loverro ◽  
G. Pace ◽  
C. Bettocchi ◽  
F. P. Selvaggi
Keyword(s):  
Prenatal Diagnosis ◽  
Urinary Tract ◽  
Urinary Tract Abnormalities ◽  
Perinatal Management

A Molecular Approach to Immunoscintigraphy: A Study of the T-Antigen Conformation on the Surface of Tumors

1987 ◽  
Vol 26 (01) ◽  
pp. 1-6 ◽  
Author(s):  
S. Selvaraj ◽  
M. R. Suresh ◽  
G. McLean ◽  
D. Willans ◽  
C. Turner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Cell ◽  
T Antigen ◽  
Human Carcinomas ◽  
Animal Tumor ◽  
Synthetic Antigens

The role of glycoconjugates in tumor cell differentiation has been well documented. We have examined the expression of the two anomers of the Thomsen-Friedenreich antigen on the surface of human, canine and murine tumor cell membranes both in vitro and in vivo. This has been accomplished through the synthesis of the disaccharide terminal residues in both a and ß configuration. Both entities were used to generate murine monoclonal antibodies which recognized the carbohydrate determinants. The determination of fine specificities of these antibodies was effected by means of cellular uptake, immunohistopathology and immunoscintigraphy. Examination of pathological specimens of human and canine tumor tissue indicated that the expressed antigen was in the β configuration. More than 89% of all human carcinomas tested expressed the antigen in the above anomeric form. The combination of synthetic antigens and monoclonal antibodies raised specifically against them provide us with invaluable tools for the study of tumor marker expression in humans and their respective animal tumor models.

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