Low-Grade Systemic Inflammation Connects Aging, Metabolic Syndrome and Cardiovascular Disease

2014 ◽  
pp. 99-106 ◽  
Author(s):  
Verónica Guarner ◽  
Maria Esther Rubio-Ruiz
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Low Grade

scholarly journals Psoriasis and metabolic syndrome: a review

2021 ◽  
Vol 17 (4) ◽  
pp. 369-374
Author(s):  
M. A. Ufimtseva ◽  
A. A. Popov ◽  
L. V. Fedotova ◽  
E. S. Mylnikova ◽  
Yu. M. Bochkarev ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Systemic Inflammation ◽  
Risk Allele ◽  
Developed Countries ◽  
Low Grade ◽  
Risk Of Mortality ◽  
Immune Mediated ◽  
Severe Rash ◽  
Pro Inflammatory Cytokines

Psoriasis is the most common chronic dermatosis and affects 1–2% of the population of developed countries. In Russia, psoriasis incidence rate has increased by 11% since 2011. Psoriasis is a chronic inflammatory and immune-mediated skin disease and it is often associated with metabolic syndrome and its components such as obesity, arterial hypertension, insulin resistance and dyslipidemia. The risk of developing metabolic syndrome in patients with psoriasis is 40% higher than in the general population. Psoriasis and metabolic syndrome share some pathogenic mechanisms such as chronic low-grade systemic inflammation and an increased level of pro-inflammatory cytokines. Systemic inflammation causes obesity, cardiovascular diseases, diabetes. These conditions increase the risk of mortality among patients. There is a link between the severity of psoriasis and metabolic syndrome and associated with severe rash, reduction of the remission and higher risk of psoriatic arthritis development. The carriers of the risk allele of FTO gene are associated with severe psoriasis, presence of psoriatic arthritis and obesity. The article presents the issues of epidemiology, etiology and pathogenesis of psoriasis and metabolic syndrome.

scholarly journals Insulin resistance in patients with psoriasis

2021 ◽  
Vol 17 (7) ◽  
pp. 570-574
Author(s):  
I.V. Pankiv
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Systemic Inflammation ◽  
Polycystic Ovary ◽  
Developed Countries ◽  
Low Grade ◽  
Nonalcoholic Fatty Liver ◽  
Systemic Inflammatory Disease

Psoriasis is a chronic systemic inflammatory disease accompanied by an activation of skin dendritic cells with accumulation in the inflammatory foci of interleukin-23 and activated Th-1 lymphocytes (Th-17, Th-22). In recent years, there has been a large number of evidence linking psoriasis with other inflammatory diseases, including obesity, diabetes mellitus, atherosclerosis, hypertension, nonalcoholic fatty liver disease, polycystic ovary syndrome, benign prostatic hyperplasia, etc. All of these conditions are associated with systemic inflammation and insulin resistance induced by it. Psoriasis is the most common chronic dermatosis and affects 1–2 % of the population in developed countries. Psoriasis as a chronic immune-mediated inflammatory skin disease is often associated with metabolic syndrome and its components such as obesity, hypertension, insulin resistance and dyslipidemia. The risk of developing metabolic syndrome in patients with psoriasis is 40 % higher than in the general population. Psoriasis and metabo­lic syndrome share some pathogenic mechanisms such as chronic low-grade systemic inflammation and an increased level of pro-inflammatory cytokines. Systemic inflammation causes obesity, cardiovascular diseases, diabetes mellitus type 2. These conditions increase the risk of mortality among patients with psoriasis. There is a positive correlation between the severity of psoriasis and metabolic syndrome, which is manifested by a severe rash, reduction of the remission and higher risk of psoriatic arthritis development. The carriers of the risk allele of FTO gene are characterized by a more severe psoriasis, the presence of psoriatic arthritis and increased body mass index. A review of the literature focuses on the relationship between insulin resistance and the pathogenesis of psoriasis.

scholarly journals Neck circumference as a predictor of metabolic syndrome, insulin resistance and low-grade systemic inflammation in children: the ACFIES study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Diego Gomez-Arbelaez ◽  
Paul Anthony Camacho ◽  
Daniel Dylan Cohen ◽  
Sandra Saavedra-Cortes ◽  
Cristina Lopez-Lopez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Neck Circumference ◽  
Low Grade

scholarly journals Obesity and asthma: co-morbidity or causal relationship?

2016 ◽  
Vol 73 (3) ◽  
Author(s):  
A. Van Huisstede ◽  
G.J. Braunstahl
Keyword(s):  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Low Grade ◽  
Fat Tissue ◽  
Rigorous Approach ◽  
The Metabolic Syndrome ◽  
Bronchial Inflammation ◽  
Co Morbidity ◽  
Few Data ◽  
The Relationship

There is substantial evidence that obesity and asthma are related. “Obese asthma” may be a unique phenotype of asthma, characterized by decreased lung volumes, greater symptoms for a given degree of lung function impairment, destabilization or lack of asthma control, lack of eosinophilic inflammation and a different response to controller medication. Whether this relationship between obesity and asthma is causal or represents co-morbidity due to other factors is unclear. In previous reviews concerning the relationship between obesity and asthma, five hypotheses were put forth. One of these hypotheses is that a low grade systemic inflammation caused by adipokines from the fat tissue causes or enhances bronchial inflammation. In animal models, there is an increasing amount of evidence for the role of adipokines derived from fat tissue in the relationship between obesity and asthma. The data are conflicting in humans. Since obesity is a component of the metabolic syndrome and the metabolic syndrome is also a form of systemic inflammation, it is to be expected that there is a relationship between metabolic syndrome and asthma. The few data that are available show that there is no relationship between metabolic syndrome and asthma, but there is one between the metabolic syndrome and asthma-like symptoms. Further research is needed to confirm the relationship between obesity and asthma in humans, where a rigorous approach in the diagnosis of asthma is essential.

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