scholarly journals Normoglycemic Diabetic Nephropathy: The Role of Insulin Resistance

2014 ◽  
Vol 4 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Edward J. Filippone ◽  
Astha Gupta ◽  
John L. Farber
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy

scholarly journals The role of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 in diabetic nephropathy

2011 ◽  
Vol 55 (9) ◽  
pp. 677-685 ◽  
Author(s):  
Denise Alves Sortica ◽  
Daisy Crispim ◽  
Guilherme Pozueco Zaffari ◽  
Rogério Friedman ◽  
Luis Henrique Canani
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Kinase Activity ◽  
Familial Aggregation ◽  
Cell Types ◽  
Chronic Complications ◽  
Nucleotide Pyrophosphatase ◽  
Enpp1 Gene ◽  
Prevalence Of Diabetes Mellitus

The increased prevalence of diabetes mellitus has caused a rise in the occurrence of its chronic complications, such as diabetic nephropathy (DN), which is associated with elevated morbidity and mortality. Familial aggregation studies have demonstrated that besides the known environmental risk factors, DN has a major genetic component. Therefore, it is necessary to identify genes associated with risk for or protection against DN. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is expressed in several tissues, including the kidneys. Increased levels of ENPP1 expression inhibit tyrosine-kinase activity of the insulin receptor in several cell types, leading to insulin resistance. K121Q polymorphism of the ENPP1 gene seems to be associated with insulin resistance and DN development. The elucidation of genetic factors and their associations will provide better understanding of the pathogenesis of DN and, may consequently, lead to a more effective approach to prevention and treatment.

scholarly journals Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

Diabetes ◽  
2011 ◽  
Vol 60 (11) ◽  
pp. 2954-2962 ◽  
Author(s):  
Kathrin Eller ◽  
Alexander Kirsch ◽  
Anna M. Wolf ◽  
Sieghart Sopper ◽  
Andrea Tagwerker ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
T Cells ◽  
Diabetic Nephropathy ◽  
Regulatory T Cells ◽  
Potential Role

scholarly journals Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytesin vitro

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1888 ◽  
Author(s):  
Ying Xu ◽  
Qi Zhou ◽  
Wei Xin ◽  
Zhaoping Li ◽  
Liyong Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Insulin Receptor ◽  
Specific Inhibitor ◽  
Podocyte Injury ◽  
Insulin Resistant ◽  
Related Proteins ◽  
Autophagy Activity

It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN). Here we used shRNA transfection to knockdown the insulin receptor (IR) gene in cultured human immortalized podocytes as anin vitroinsulin resistant model. Autophagy related proteins LC3, Beclin, and p62 as well as nephrin, a podocyte injury marker, were assessed using western blot and immunofluorescence staining. Our results show that autophagy is suppressed when podocytes lose insulin sensitivity and that treatment of rapamycin, an mTOR specific inhibitor, could attenuate insulin resistance induced podocytes injury via autophagy activation. The present study deepens our understanding of the role of autophagy in the pathogenesis of DN.

Altered bone metabolism after high fat diet and exercise: role of Wnt signaling and insulin resistance

2016 ◽  
Author(s):  
Ann-Kristin Picke ◽  
Lykke Sylow ◽  
Lisbeth L V Moller ◽  
Rasmus Kjobsted ◽  
Erik Richter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Wnt Signaling ◽  
Bone Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Diet And Exercise

The role of androgens in PCOS-related insulin resistance

2015 ◽  
Author(s):  
Michael O'Reilly ◽  
Jeremy Tomlinson ◽  
Robert Semple ◽  
Wiebke Arlt
Keyword(s):  
Insulin Resistance
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