Wolffian Duct Development

2014 ◽  
Vol 8 (5) ◽  
pp. 273-280 ◽  
Author(s):  
Geoffrey Shaw ◽  
Marilyn B. Renfree
Keyword(s):  
Wolffian Duct ◽  
Duct Development

Effects of in utero linuron exposure on rat Wolffian duct development

2002 ◽  
Vol 16 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Barry S. McIntyre ◽  
Norman J. Barlow ◽  
Madhabananda Sar ◽  
Duncan G. Wallace ◽  
Paul M.D. Foster
Keyword(s):  
In Utero ◽  
Wolffian Duct ◽  
Duct Development

Global Gene Expression Patterns in Mouse Wolffian Duct Development

2006 ◽  
Vol 176 (4S) ◽  
pp. 1701-1705 ◽  
Author(s):  
Gerald Mingin ◽  
D. Alan Stahl ◽  
Job Chacko ◽  
Hari Koul
Keyword(s):  
Gene Expression ◽  
Expression Patterns ◽  
Global Gene Expression ◽  
Wolffian Duct ◽  
Gene Expression Patterns ◽  
Duct Development

scholarly journals Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron

2003 ◽  
Vol 74 (1) ◽  
pp. 114-128 ◽  
Author(s):  
Katie J. Turner ◽  
Barry S. McIntyre ◽  
Suzanne L. Phillips ◽  
Norman J. Barlow ◽  
Christopher J. Bowman ◽  
...  
Keyword(s):  
Gene Expression ◽  
In Utero ◽  
Wolffian Duct ◽  
In Utero Exposure ◽  
Altered Gene Expression ◽  
Altered Gene ◽  
Duct Development

scholarly journals Ectopic expression of FGF-3 results in abnormal prostate and Wolffian duct development

Oncogene ◽  
2002 ◽  
Vol 21 (12) ◽  
pp. 1899-1908 ◽  
Author(s):  
Steven S Chua ◽  
Zhi-Qing Ma ◽  
Lei Gong ◽  
Sue-Hwa Lin ◽  
Francesco J DeMayo ◽  
...  
Keyword(s):  
Ectopic Expression ◽  
Wolffian Duct ◽  
Duct Development

scholarly journals Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development

2015 ◽  
Vol 400 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Mika Okazawa ◽  
Aki Murashima ◽  
Masayo Harada ◽  
Naomi Nakagata ◽  
Masafumi Noguchi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wolffian Duct ◽  
Receptor Signaling ◽  
Fgf Receptor ◽  
Specific Regulation ◽  
Duct Development

Wolffian Duct Development

2018 ◽  
pp. 256-262 ◽  
Author(s):  
Barry T. Hinton ◽  
Maria Christina W. Avellar
Keyword(s):  
Wolffian Duct ◽  
Duct Development

scholarly journals Androgen-Dependent Mechanisms of Wolffian Duct Development and Their Perturbation by Flutamide

Endocrinology ◽  
2006 ◽  
Vol 147 (10) ◽  
pp. 4820-4830 ◽  
Author(s):  
Michelle Welsh ◽  
Philippa T. K. Saunders ◽  
Nicholas I. Marchetti ◽  
Richard M. Sharpe
Keyword(s):  
Cell Proliferation ◽  
Androgen Receptor ◽  
Smooth Muscle Actin ◽  
Vital Role ◽  
Wolffian Duct ◽  
In Utero Exposure ◽  
Pregnant Rats ◽  
Androgen Receptor Antagonist ◽  
Proliferation And Apoptosis ◽  
Duct Development

Androgens play a vital role in Wolffian duct (WD) development, but the mechanisms that underlie this are unknown. The present study used in utero exposure of pregnant rats to the androgen receptor antagonist flutamide (50 or 100 mg/kg) to explore possible mechanisms. Pregnant rats were treated from embryonic d 15.5 (E15.5), and WDs were isolated from fetuses from E17.5–E21.5 and from adults. WD morphology was evaluated, and total length of the duct lumen was determined in fetal samples. Fetal WDs were immunostained for androgen receptor and stromal (inner and outer) and/or epithelial-cell-specific markers and analyzed for cell proliferation and apoptosis. In adulthood, most flutamide-exposed males lacked proximal WD-derived tissues, whereas at E18.5–E19.5, a time when the WD has completely regressed in females, a complete normal WD was present in all flutamide-exposed animals. This suggests that flutamide, at doses of 50 or 100 mg/kg, interferes with WD differentiation, not stabilization. Consistent with this, WD elongation/coiling increased in controls by 204% between E19.5 and E21.5 but increased less significantly (103%) in flutamide-exposed animals. This was associated with reduced cell proliferation, but there was no increase in apoptosis or change in expression of androgen receptor mRNA or protein. Flutamide treatment impaired differentiation of inner stromal cells, shown by decreased expression of smooth muscle actin, before effects were noted in the epithelium, consistent with androgens driving WD development via stromal-epithelial interactions. In conclusion, WD differentiation is far more susceptible to blockade of androgen action than is its initial stabilization, and these effects may be mediated by disruption of stromal-epithelial interactions.

scholarly journals Perturbations of genes essential for Müllerian duct and Wölffian duct development in Mayer-Rokitansky-Küster-Hauser syndrome

2021 ◽  
Vol 108 (2) ◽  
pp. 337-345
Author(s):  
Na Chen ◽  
Sen Zhao ◽  
Angad Jolly ◽  
Lianlei Wang ◽  
Hongxin Pan ◽  
...  
Keyword(s):  
Wolffian Duct ◽  
Mullerian Duct ◽  
Müllerian Duct ◽  
Duct Development
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