Human Fetal Thyroid Function

2014 ◽  
pp. 17-25 ◽  
Author(s):  
Michel Polak
Keyword(s):  
Thyroid Function ◽  
Fetal Thyroid

scholarly journals Fetal Thyroid Function, Birth Weight, andin UteroExposure to Fine Particle Air Pollution: A Birth Cohort Study

2017 ◽  
Vol 125 (4) ◽  
pp. 699-705 ◽  
Author(s):  
Bram G. Janssen ◽  
Nelly D. Saenen ◽  
Harry A. Roels ◽  
Narjes Madhloum ◽  
Wilfried Gyselaers ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Thyroid Function ◽  
Fine Particle ◽  
Birth Cohort Study ◽  
Fetal Thyroid

scholarly journals Fetal Thyroid Hormone Level at Birth Is Associated with Fetal Growth

2011 ◽  
Vol 96 (6) ◽  
pp. E934-E938 ◽  
Author(s):  
Beverley M. Shields ◽  
Beatrice A. Knight ◽  
Anita Hill ◽  
Andrew T. Hattersley ◽  
Bijay Vaidya
Keyword(s):  
Birth Weight ◽  
Thyroid Hormone ◽  
Cord Blood ◽  
Thyroid Function ◽  
Fetal Growth ◽  
Late Gestation ◽  
Third Trimester ◽  
Free T4 ◽  
Skeletal Size ◽  
Fetal Thyroid

Context: Thyroid function is known to play an important role in fetal neurological development, but its role in regulating fetal growth is not well established. Overt maternal and fetal thyroid disorders are associated with reduced birth weight. We hypothesized that, even in the absence of overt thyroid dysfunction, maternal and fetal thyroid function influence fetal growth. Aim: In normal, healthy pregnancies, we aimed to assess whether fetal thyroid hormone at birth (as measured in cord blood) is associated with fetal growth. We also aimed to study whether fetal thyroid hormone at birth is associated with maternal thyroid hormone in the third trimester. Methods: In 616 healthy mother-child pairs, TSH, free T4 (FT4), and free T3 (FT3) were measured in mothers at 28 wk gestation and in umbilical cord blood at birth. Birth weight, length, head circumference, and tricep and bicep skinfold thicknesses were measured on the babies. Results: Cord FT4 was associated with birth weight (r = 0.25; P < 0.001), length (r = 0.17; P < 0.001), and sum of skinfolds (r = 0.19; P < 0.001). There were no associations between birth measurements and either cord TSH or cord FT3. Maternal FT4 and cord FT4 were correlated (r = 0.14; P = 0.0004), and there were weaker negative associations between maternal TSH and cord FT4 (r = −0.08; P = 0.04) and FT3 (r = −0.10; P = 0.01). Conclusion: Associations between cord FT4 and birth size suggest that fetal thyroid function may be important in regulating fetal growth, both of skeletal size and fat. The correlation between third-trimester maternal FT4 and cord FT4 supports the belief that maternal T4 crosses the placenta even in late gestation.

Unexpectedly Expected Fetal Thyroid Function on Posttreated Radioiodine (131I) SPECT/CT of a Patient With Differentiated Thyroid Cancer

2014 ◽  
Vol 39 (11) ◽  
pp. 1017-1018 ◽  
Author(s):  
Wichana Chamroonrat ◽  
Chanika Sritara ◽  
Chirawat Utamakul ◽  
Arpakorn Kositwattanarerk ◽  
Kanungnij Thamnirat ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Function ◽  
Differentiated Thyroid Cancer ◽  
Fetal Thyroid

Adverse effect of amniofetography on fetal thyroid function

1976 ◽  
Vol 126 (6) ◽  
pp. 723-726 ◽  
Author(s):  
F. Rodesch ◽  
M. Camus ◽  
A.M. Ermans ◽  
J. Dodion ◽  
F. Delange
Keyword(s):  
Adverse Effect ◽  
Thyroid Function ◽  
Fetal Thyroid

The effect of thyroxine, 3,5-dimethyl-3'-isopropyl-L-thyronine and iodized oil on fetal brain development in the iodine-deficient sheep

1989 ◽  
Vol 121 (1) ◽  
pp. 7-15 ◽  
Author(s):  
M. T. Mano ◽  
B.J. Potter ◽  
G. B. Belling ◽  
D. M. Martin ◽  
B. G. Gragg ◽  
...  
Keyword(s):  
Brain Development ◽  
Thyroid Function ◽  
Iodine Deficiency ◽  
Fetal Brain ◽  
Maternal Plasma ◽  
Iodized Oil ◽  
Irreversible Damage ◽  
Fetal Plasma ◽  
Fetal Brain Development ◽  
Fetal Thyroid

Abstract. Studies have been carried out to investigate the role of maternal and fetal thyroid function in the effects of iodine deficiency on fetal brain development in sheep. Iodine deficiency was established with an especially prepared low-iodine diet of maize and pea pollard. The iodine-deficient sheep were mated and at the end of the second trimester of pregnancy (100 days gestation) were divided into groups which received either a sc injection of T4 or 3,5-dimethyl-3'-isopropyl-L-thyronine or an im injection of iodized oil. At 140 days gestation (10 days prior to parturition) comparison of the fetuses delivered by hysterotomy revealed that the retarded fetal brain development observed in iodine deficiency was greatly improved by T4 and by iodized oil. However, T4 and iodized oil failed to correct the reduction in the number and the increase in the length of synaptic appositions which were observed in the fetal cerebral cortex after iodine deficiency. In addition, the histological appearance of the fetal thyroid gland and the levels of plasma thyroid hormones were restored to normal. The administration of 3,5-dimethyl-3'-isopropyl-L-thyronine had no effect on the retarded fetal brain and body development of the iodine-deficient fetuses. The lack of response may be due to the inability of 3,5-dimethyl-3'-isopropyl-L-thyronine to cross the ovine placenta as no reduction in the abnormally elevated fetal plasma TSH was observed in spite of a fall in maternal plasma TSH and apparent restoration of maternal thyroid function. It is concluded that the retarded fetal brain development observed during iodine deficiency in sheep can be substantially improved by iodized oil or to a lesser extent by T4 administration at 100 days gestation and that this is dependent on the restoration of both maternal and fetal thyroid function which supports previous observations from this laboratory following fetal and maternal thyroidectomy. The persistence of some effects of iodine deficiency on the fetal brain suggests that irreversible damage may have occurred.

Fetal Thyroid Function

Thyroid ◽  
1992 ◽  
Vol 2 (3) ◽  
pp. 207-217 ◽  
Author(s):  
J.G. THORPE-BEESTON ◽  
K.H. NICOLAIDES ◽  
A.M. McGREGOR
Keyword(s):  
Thyroid Function ◽  
Fetal Thyroid

scholarly journals Compound W, a 3,3′-Diiodothyronine Sulfate Cross-Reactive Substance in Serum from Pregnant Women—A Potential Marker for Fetal Thyroid Function

2007 ◽  
Vol 61 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Sing-Yung Wu ◽  
Wen-Sheng Huang ◽  
Eugene Ho ◽  
Elizabeth S C Wu ◽  
Delbert A Fisher
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Reactive Substance ◽  
Potential Marker ◽  
Fetal Thyroid
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