Breslow Thickness, Clark Index and Ulceration Are Associated with Sentinel Lymph Node Metastasis in Melanoma Patients: A Cohort Analysis of 612 Patients

Dermatology ◽  
2014 ◽  
Vol 229 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Coline Munsch ◽  
Valérie Lauwers-Cances ◽  
Laurence Lamant ◽  
Catherine Gentil ◽  
Philippe Rochaix ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Cohort Analysis ◽  
Breslow Thickness ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis ◽  
Melanoma Patients

Factors Associated With Improved Survival Among Young Adult Melanoma Patients Despite a Greater Incidence of Sentinel Lymph Node Metastasis

2007 ◽  
Vol 143 (1) ◽  
pp. 164-168 ◽  
Author(s):  
Ryaz B. Chagpar ◽  
Merrick I. Ross ◽  
Douglas S. Reintgen ◽  
Michael J. Edwards ◽  
Charles R. Scoggins ◽  
...  
Keyword(s):  
Lymph Node ◽  
Young Adult ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Lymph Node Metastasis ◽  
Factors Associated ◽  
Node Metastasis ◽  
Melanoma Patients

Age and Lymphovascular Invasion Accurately Predict Sentinel Lymph Node Metastasis in T2 Melanoma Patients

2019 ◽  
Vol 26 (12) ◽  
pp. 3955-3961 ◽  
Author(s):  
Michael E. Egger ◽  
Megan Stevenson ◽  
Neal Bhutiani ◽  
Adrienne C. Jordan ◽  
Charles R. Scoggins ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymphovascular Invasion ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis ◽  
Melanoma Patients

scholarly journals Absence of Granzyme B Positive Tumour-Infiltrating Lymphocytes in Primary Melanoma Excisional Biopsies is Strongly Associated with the Presence of Sentinel Lymph Node Metastasis

2009 ◽  
Vol 31 (5) ◽  
pp. 407-413
Author(s):  
I. S. van Houdt ◽  
B. J. R. Sluijter ◽  
P. A. M. van Leeuwen ◽  
L. M. Moesbergen ◽  
E. Hooijberg ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Granzyme B ◽  
Primary Melanoma ◽  
Sentinel Lymph Node Metastasis ◽  
Mhc I ◽  
Node Metastasis ◽  
Melanoma Patients ◽  
Infiltrating Lymphocytes

Background: Sentinel Lymph Node (SLN) status is strongly related to clinical outcome in melanoma patients. In this study we investigated the possible association between the presence of activated and/or suppressive Tumour Infiltrating Lymphocytes (TILs) and SLN status in clinically stage I/II melanoma patients.Methods: Diagnostic primary melanoma samples from 20 patients with a sentinel lymph node metastasis were compared to melanoma samples from 20 patients with a negative sentinel lymph node, who were matched for gender, age and Breslow thickness. Presence of activated Granzyme B positive (GrB+) TILs, presence of suppressive (FoxP3+) TILs and MHC class I antigen expression on tumour cells were analysed by immunohistochemistry.Results: FoxP3 and MHC-I expression had no direct bearing on the presence of melanoma metastases in the SLN. Whereas the presence of activated GrB+ TILs in the primary melanoma had no predictive value for SLN status either, their absence was strongly associated with the presence of metastasis in the SLN (p=0.001). While both GrB+ and FoxP3+ TILs could be detected in SLN metastases, a majority did not display MHC-I expression.Conclusions: These data support a role for cytotoxic T cells in the prevention of early metastasis of melanoma to the draining lymph nodes.

Age and Mitogenicity are Important Predictors of Sentinel Lymph Node Metastasis in T1a Melanoma

2021 ◽  
Author(s):  
Adrienne B. Shannon ◽  
Christian Wood ◽  
Richard J. Straker ◽  
John T. Miura ◽  
Michael E. Ming ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis
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