scholarly journals Occupational Exposure to Mineral Turpentine and Heavy Fuels: A Possible Risk Factor for Alzheimer's Disease

2014 ◽  
Vol 4 (2) ◽  
pp. 160-171 ◽  
Author(s):  
Rafik Helou ◽  
Pierre Jaecker
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Occupational Exposure ◽  
Heavy Fuels

Repurposing Antihypertensive Drugs for the Management of Alzheimer’s Disease

2020 ◽  
Vol 27 ◽  
Author(s):  
Keng Yoon Yeong ◽  
Christine Law
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Literature Review ◽  
Neurodegenerative Disorder ◽  
Antihypertensive Drugs ◽  
Future Prospects ◽  
Short Term

Alzheimer’s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Thus, antihypertensives are postulated to be beneficial in managing AD. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD, considering recent updates. Four classes of antihypertensives, as well as their potential limitations and future prospects in being utilised as AD therapeutics are discussed in this review.

scholarly journals Interactions between sleep disturbances and Alzheimer’s disease on brain function: a preliminary study combining the static and dynamic functional MRI

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kaicheng Li ◽  
Xiao Luo ◽  
Qingze Zeng ◽  
Yerfan Jiaerken ◽  
Shuyue Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Sleep Disturbance ◽  
Brain Function ◽  
Sleep Disturbances ◽  
Brain Activity ◽  
Vascular Risk Factor ◽  
Underlying Mechanism ◽  
Amyloid Pet

AbstractThough sleep disturbance constitutes the risk factor for Alzheimer’s disease (AD), the underlying mechanism is still unclear. This study aims to explore the interaction between sleep disturbances and AD on brain function. We included 192 normal controls, 111 mild cognitive impairment (MCI), and 30 AD patients, with either poor or normal sleep (PS, NS, respectively). To explore the strength and stability of brain activity, we used static amplitude of low-frequency fluctuation (sALFF) and dynamic ALFF (dALFF) variance. Further, we examined white matter hyperintensities (WMH) and amyloid PET deposition, representing the vascular risk factor and AD-related hallmark, respectively. We observed that sleep disturbance significantly interacted with disease severity, exposing distinct effects on sALFF and dALFF variance. Interestingly, PS groups showed the dALFF variance trajectory of initially increased, then decreased and finally increased along the AD spectrum, while showing the opposite trajectory of sALFF. Further correlation analysis showed that the WMH burden correlates with dALFF variance in PS groups. Conclusively, our study suggested that sleep disturbance interacts with AD severity, expressing as effects of compensatory in MCI and de-compensatory in AD, respectively. Further, vascular impairment might act as important pathogenesis underlying the interaction effect between sleep and AD.

P3-132: Motivational reserve as risk factor in the development of mild cognitive impairment and Alzheimer's disease: Cross-sectional and longitudinal data

2009 ◽  
Vol 5 (4S_Part_13) ◽  
pp. P383-P383
Author(s):  
Simon Forstmeier ◽  
Michael Wagner ◽  
Wolfgang Maier ◽  
Hendrik Van Den Bussche ◽  
Birgitt Wiese ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Data ◽  
Cross Sectional

Hyperhomocysteinemia Is a Risk Factor for Alzheimer's Disease in an Algerian Population

2014 ◽  
Vol 45 (3) ◽  
pp. 247-250 ◽  
Author(s):  
Khaled Nazef ◽  
Malika Khelil ◽  
Hiba Chelouti ◽  
Ghouti Kacimi ◽  
Mohamed Bendini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Algerian Population

scholarly journals Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

2003 ◽  
Vol 23 (11) ◽  
pp. 2055-2062 ◽  
Author(s):  
Alex E. Roher ◽  
Chera Esh ◽  
Tyler A. Kokjohn ◽  
Walter Kalback ◽  
Dean C. Luehrs ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Circle Of Willis ◽  
Sporadic Alzheimer’S Disease

scholarly journals Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease

2012 ◽  
Vol 8 (3) ◽  
pp. 196-203 ◽  
Author(s):  
Pamela Sparks Stein ◽  
Michelle J. Steffen ◽  
Charles Smith ◽  
Gregory Jicha ◽  
Jeffrey L. Ebersole ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Periodontal Pathogens ◽  
Serum Antibodies
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