scholarly journals Investigating Epigenetic Effects of Prenatal Exposure to Toxic Metals in Newborns: Challenges and Benefits

2014 ◽  
Vol 2 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Monica D. Nye ◽  
Rebecca C. Fry ◽  
Cathrine Hoyo ◽  
Susan K. Murphy
Keyword(s):  
Prenatal Exposure ◽  
Toxic Metals ◽  
Epigenetic Effects

scholarly journals Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

2021 ◽  
Vol 8 ◽  
Author(s):  
Boyd R. Rorabaugh
Keyword(s):  
Cardiovascular System ◽  
Prenatal Exposure ◽  
Behavioral Outcomes ◽  
Adult Offspring ◽  
Gestational Period ◽  
Epigenetic Effects ◽  
Cns Stimulants ◽  
Young Offspring ◽  
Uterine Environment ◽  
The Impact

Prenatal exposure to an adverse uterine environment can have long lasting effects on adult offspring through DNA methylation, histone acetylation, and other epigenetic effects that alter gene expression and physiology. It is well-known that consumption of CNS stimulants such as caffeine, nicotine, amphetamines, and cocaine during pregnancy can adversely impact the offspring. However, most work in this area has focused on neurological and behavioral outcomes and has been limited to assessments in young offspring. The impact of prenatal exposure to these agents on the adult cardiovascular system has received relatively little attention. Evidence from both animal and human studies indicate that exposure to CNS stimulants during the gestational period can negatively impact the adult heart and vasculature, potentially leading to cardiovascular diseases later in life. This review discusses our current understanding of the impact of prenatal exposure to cocaine, methamphetamine, nicotine, and caffeine on the adult cardiovascular system.

scholarly journals Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome

Epigenomics ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 333-350 ◽  
Author(s):  
Paige A Bommarito ◽  
Elizabeth Martin ◽  
Rebecca C Fry
Keyword(s):  
Endocrine Disruptors ◽  
Prenatal Exposure ◽  
Toxic Metals

Reversal of cardiomyopathy resulting from prenatal exposure to ethanol

1984 ◽  
Vol 42 ◽  
pp. 716-717
Author(s):  
C. Uphoff ◽  
C. Nyquist-Battie
Keyword(s):  
Prenatal Exposure ◽  
Heart Development ◽  
Membrane Integrity ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Pathological Changes ◽  
Prenatally Exposed ◽  
Inner Mitochondrial Membrane ◽  
Fetal Alcohol ◽  
Newborn Mice

Fetal Alcohol Syndrone (FAS) is a syndrome with characteristic abnormalities resulting from prenatal exposure to ethanol. In many children with FAS syndrome gross pathological changes in the heart are seen with septal defects the most prevalent abnormality recorded. Few studies in animal models have been performed on the effects of ethanol on heart development. In our laboratory, it has been observed that prenatal ethanol exposure of Swiss albino mice results in abnormal cardiac muscle ultrastructure when mice were examined at birth and compared to pairfed and normal controls. Fig. 1 is an example of the changes that are seen in the ethanol-exposed animals. These changes include enlarged mitochondria with loss of inner mitochondrial membrane integrity and loss of myofibrils. Morphometric analysis substantiated the presence of these alterations from normal cardiac ultrastructure. The present work was undertaken to determine if the pathological changes seen in the newborn mice prenatally exposed to ethanol could be reversed with age and abstinence.

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