Additive Interactions between 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Clobazam in the Mouse Maximal Electroshock-Induced Tonic Seizure Model - An Isobolographic Analysis for Parallel Dose-Response Relationship Curves

Pharmacology ◽  
2014 ◽  
Vol 93 (3-4) ◽  
pp. 172-177 ◽  
Author(s):  
Marta Andres-Mach ◽  
Agnieszka Haratym-Maj ◽  
Mirosław Zagaja ◽  
Jarogniew J. Luszczki
Keyword(s):  
Dose Response ◽  
Maximal Electroshock ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Isobolographic Analysis ◽  
Tonic Seizure ◽  
Seizure Model ◽  
Additive Interactions

scholarly journals Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis

2015 ◽  
Vol 26 (1) ◽  
pp. 82-87
Keyword(s):  
Dose Response ◽  
Seizure Activity ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Additive Interaction ◽  
Isobolographic Analysis ◽  
Psychomotor Seizure ◽  
Seizure Model ◽  
A Current ◽  
Anticonvulsant Effects

The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with lamotrigine (LTG – a second-generation antiepileptic drug), in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to characterize the consequent anticonvulsant interactions between the drug combinations. Results indicated that LEV administered singly was associated with a DRRC that was parallel to that for LTG. With isobolography for parallel DRRCs, the combination of LEV with LTG at three fixed-ratios of 1:3, 1:1 and 3:1 exerted additive interaction. LEV combined with LTG exerted additive interaction in the mouse 6 Hz psychomotor seizure model.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

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