Late Diagnosis of COL4A1 Mutation and Problematic Vascular Risk Factor Management

2014 ◽  
Vol 72 (3-4) ◽  
pp. 150-152 ◽  
Author(s):  
Eloi Magnin ◽  
Xavier Ayrignac ◽  
Eric Berger ◽  
Manuele Mine ◽  
Elisabeth Tournier-Lasserve ◽  
...  
Keyword(s):  
Risk Factor ◽  
Vascular Risk Factor ◽  
Late Diagnosis ◽  
Vascular Risk ◽  
Risk Factor Management

scholarly journals Internet based vascular risk factor management for patients with clinically manifest vascular disease: randomised controlled trial

BMJ ◽  
2012 ◽  
Vol 344 (jun12 1) ◽  
pp. e3750-e3750 ◽  
Author(s):  
J. W. P. Vernooij ◽  
H. A. H. Kaasjager ◽  
Y. van der Graaf ◽  
J. Wierdsma ◽  
H. M. H. Grandjean ◽  
...  
Keyword(s):  
Risk Factor ◽  
Randomised Controlled Trial ◽  
Vascular Disease ◽  
Controlled Trial ◽  
Vascular Risk Factor ◽  
Vascular Risk ◽  
Risk Factor Management ◽  
Randomised Controlled

The role of self-efficacy in vascular risk factor management: A randomized controlled trial

2008 ◽  
Vol 71 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Berna G.M. Sol ◽  
Yolanda van der Graaf ◽  
Jaap J. van der Bijl ◽  
Bertine M.B. Goessens ◽  
Frank L.J. Visseren
Keyword(s):  
Randomized Controlled Trial ◽  
Risk Factor ◽  
Self Efficacy ◽  
Controlled Trial ◽  
Vascular Risk Factor ◽  
Vascular Risk ◽  
Risk Factor Management ◽  
Randomized Controlled

scholarly journals Can Cardiovascular Risk Management be improved by Shared Care with General Practice to Prevent Cognitive Decline Following Stroke/TIA? A feasibility randomised controlled Trial (SERVED Memory)

2020 ◽  
Author(s):  
William Davison ◽  
Phyo K Myint ◽  
Yoon K Loke ◽  
Garth Ravenhill ◽  
David A Turner ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Randomised Trial ◽  
Vascular Risk Factor ◽  
Vascular Risk ◽  
Risk Factor Management ◽  
Post Stroke ◽  
Observational Cohort ◽  
Normal Cognition

Abstract BackgroundCognitive impairment and dementia following cerebrovascular disease are increasingly common in the UK. One potential strategy to prevent post-stroke cognitive decline is multimodal vascular risk factor management. However, its efficacy remains uncertain and its application in vulnerable patients with incident cerebrovascular disease and early cognitive impairment has not been assessed.The primary aim of this study was to assess the feasibility of recruitment and retention of patients with early cognitive impairment post-stroke or transient ischaemic attack (TIA) to a trial of enhanced vascular risk factor management combining primary and secondary care.MethodsIn this single centre, open label trial adults with a recent stroke or TIA and mild cognitive impairment (MCI) were randomised 1:1 to a three-monthly multimodal vascular risk factor intervention jointly delivered by the trial team and General Practitioner (GP), or control (defined as usual care from the GP). Chosen risk factors were blood pressure (BP), total cholesterol, blood glucose (HbA1C) in those with diabetes, and heart rate and adequacy of anticoagulation in those with atrial fibrillation (AF). Similar patients with normal cognition were enrolled in an embedded observational cohort and also received usual care from the GP. Repeat cognitive screening was undertaken in all participants after 12 months.ResultsSeventy three participants were recruited to the randomised trial and 94 to the observational cohort (21.8% of those screened). From the randomised trial 35/73 (47.9%) dropped out before final follow-up. In all groups guideline based rates of risk factor control were mostly poor at baseline and did not significantly improve during follow-up. The observational cohort demonstrated greater decline in cognitive test scores at 12 months, with no difference between the randomised groups.ConclusionsRecruitment to such a study was feasible, but retention of participants was difficult and generally poor rates of risk factor control suggested insufficient application of the intervention. Consequently, successful scaling up of the trial would require protocol changes with less reliance on primary care services. Any future trial should include participants with normal cognition post-stroke as they may be at greatest risk of cognitive decline.Trial RegistrationISRCTN, ISRCTN42688361. Registered 16 April 2015, https://www.isrctn.com/ISRCTN42688361

scholarly journals Can cardiovascular risk management be improved by shared care with general practice to prevent cognitive decline following stroke/TIA? A feasibility randomised controlled trial (SERVED memory)

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
William J. Davison ◽  
Phyo K. Myint ◽  
Yoon K. Loke ◽  
Garth Ravenhill ◽  
David Turner ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Randomised Trial ◽  
Vascular Risk Factor ◽  
Vascular Risk ◽  
Risk Factor Management ◽  
Post Stroke ◽  
Observational Cohort

Abstract Background Cognitive impairment and dementia following cerebrovascular disease are increasingly common in the UK. One potential strategy to prevent post-stroke cognitive decline is multimodal vascular risk factor management. However, its efficacy remains uncertain and its application in vulnerable patients with incident cerebrovascular disease and early cognitive impairment has not been assessed. The primary aim of this study was to assess the feasibility of recruitment and retention of patients with early cognitive impairment post-stroke or transient ischaemic attack (TIA) to a trial of enhanced vascular risk factor management combining primary and secondary care. Methods In this single centre, open label trial adults with a recent stroke or TIA and mild cognitive impairment (MCI) were randomised 1:1 to a three-monthly multimodal vascular risk factor intervention jointly delivered by the trial team and General Practitioner (GP), or control (defined as usual care from the GP). Chosen risk factors were blood pressure (BP), total cholesterol, blood glucose (HbA1C) in those with diabetes, and heart rate and adequacy of anticoagulation in those with atrial fibrillation (AF). Similar patients with normal cognition were enrolled in an embedded observational cohort and also received usual care from the GP. Repeat cognitive screening was undertaken in all participants after 12 months. Results Seventy three participants were recruited to the randomised trial and 94 to the observational cohort (21.8% of those screened). From the randomised trial 35/73 (47.9%) dropped out before final follow-up. In all groups guideline based rates of risk factor control were mostly poor at baseline and did not significantly improve during follow-up. The observational cohort demonstrated greater decline in cognitive test scores at 12 months, with no difference between the randomised groups. Conclusions Recruitment to such a study was feasible, but retention of participants was difficult and generally poor rates of risk factor control suggested insufficient application of the intervention. Consequently, successful scaling up of the trial would require protocol changes with less reliance on primary care services. Any future trial should include participants with normal cognition post-stroke as they may be at greatest risk of cognitive decline. Trial registration ISRCTN, ISRCTN42688361. Registered 16 April 2015.

scholarly journals A cluster randomised controlled trial of vascular risk factor management in general practice

2012 ◽  
Vol 197 (7) ◽  
pp. 387-393 ◽  
Author(s):  
Mark F Harris ◽  
Mahnaz Fanaian ◽  
Upali W Jayasinghe ◽  
Megan E Passey ◽  
Suzanne H McKenzie ◽  
...  
Keyword(s):  
General Practice ◽  
Risk Factor ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
Vascular Risk Factor ◽  
Vascular Risk ◽  
Risk Factor Management ◽  
Cluster Randomised ◽  
Randomised Controlled
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