Non-Alcoholic Fatty Liver Disease: Diagnosis and Investigation

2014 ◽  
Vol 32 (5) ◽  
pp. 586-596 ◽  
Author(s):  
Fabio Nascimbeni ◽  
Paola Loria ◽  
Vlad Ratziu
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Disease Diagnosis ◽  
Alcoholic Fatty Liver ◽  
Liver Disease Diagnosis ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease diagnosis, grading and staging; a simplified tool for clinicians

2017 ◽  
Vol 6 (1) ◽  
pp. 15 ◽  
Author(s):  
Arvind Kumar ◽  
Anupam Kumar Singh ◽  
Prasan Kumar Panda ◽  
Neeraj Nischal ◽  
Manish Soneja
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Disease Diagnosis ◽  
Alcoholic Fatty Liver ◽  
Liver Disease Diagnosis ◽  
Alcoholic Fatty Liver Disease

scholarly journals New Aspects of Non-alcoholic Fatty Liver Disease

Doctor Ru ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 33-39
Author(s):  
V.V. Tsukanov ◽  
◽  
A.V. Vasyutin ◽  
Yu.L. Tonkikh ◽  
◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Disease Diagnosis ◽  
Alcoholic Fatty Liver ◽  
Metabolic Dysregulation ◽  
Laboratory Confirmation ◽  
International Experts ◽  
Available Information ◽  
Alcoholic Fatty Liver Disease

Objective of the Review: To analyse available information on various aspects of non-alcoholic fatty liver disease (NAFLD). Key Points. A group of international experts proposed to replace the terms “NAFLD” with “metabolism-associated fatty liver disease” (MAFLD) which, in the opinion of experts, more adequately reflects the nature of the disease. The proposal is related to the fact that the disease is associated with multi system disorders and is a heterogeneous pathology with various causes, signs and progress. The experts suggested that the criteria for MAFLD diagnosis are hepatic steatosis with histological, visual or laboratory confirmation and one of the three signs: overweight/ obesity, type 2 diabetes mellitus, or verified metabolic dysregulation. Conclusion. Replacement of NAFLD with MAFLD proposed by the experts is highly likely to be officially approved soon. Keywords: non-alcoholic fatty liver disease, metabolism-associated fatty liver disease, diagnosis, management, hepatic fibrosis.

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

2008 ◽  
Vol 78 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Suano de Souza ◽  
Silverio Amancio ◽  
Saccardo Sarni ◽  
Sacchi Pitta ◽  
Fernandes ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Profile ◽  
Fatty Liver Disease ◽  
Thiobarbituric Acid ◽  
Serum Levels ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

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