Fine Needle Cytology and Flow Cytometry in Hashimoto Thyroiditis and Primary Thyroid Lymphoma

2014 ◽  
Vol 58 (3) ◽  
pp. 318-318 ◽  
Author(s):  
Pio Zeppa ◽  
Mario Vitale
Keyword(s):  
Flow Cytometry ◽  
Hashimoto Thyroiditis ◽  
Thyroid Lymphoma ◽  
Fine Needle ◽  
Fine Needle Cytology ◽  
Primary Thyroid Lymphoma

scholarly journals Cytologic, flow cytometry, and molecular assessment of lymphoid infiltrate in fine-needle cytology samples of Hashimoto thyroiditis

2009 ◽  
Vol 117 (3) ◽  
pp. 174-184 ◽  
Author(s):  
Pio Zeppa ◽  
Immacolata Cozzolino ◽  
Anna Lucia Peluso ◽  
Giancarlo Troncone ◽  
Antonio Lucariello ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Hashimoto Thyroiditis ◽  
Fine Needle ◽  
Lymphoid Infiltrate ◽  
Fine Needle Cytology ◽  
Molecular Assessment

Primary thyroid lymphoma: Can the diagnosis be made solely by fine-needle aspiration?

2002 ◽  
Vol 9 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Charles Cha ◽  
Herbert Chen ◽  
William H. Westra ◽  
Robert Udelsman
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Thyroid Lymphoma ◽  
Fine Needle ◽  
Primary Thyroid Lymphoma

Fine-Needle Cytology and Flow Cytometry Assessment of Reactive and Lymphoproliferative Processes of the Breast

2012 ◽  
Vol 56 (2) ◽  
pp. 130-138 ◽  
Author(s):  
Elena Vigliar ◽  
Immacolata Cozzolino ◽  
Laura Virginia Sosa Fernandez ◽  
Leda Di Pietto ◽  
Albina Riccardi ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Fine Needle ◽  
Fine Needle Cytology

The diagnosis of primary thyroid lymphoma by fine‐needle aspiration, cell block, and immunohistochemistry technique

2020 ◽  
Vol 48 (11) ◽  
pp. 1041-1047
Author(s):  
Cong‐Gai Huang ◽  
Meng‐Ze Li ◽  
Shao‐Hua Wang ◽  
Tie‐Jun Zhou ◽  
Johannes Haybaeck ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Cell Block ◽  
Thyroid Lymphoma ◽  
Fine Needle ◽  
Primary Thyroid Lymphoma

Combined fine needle cytology and flow cytometry immunophenotyping for diagnosis of lymphoid disorders

2008 ◽  
Vol 49 (6) ◽  
pp. 1212-1213
Author(s):  
Giovanni D'Arena ◽  
Nicola Cascavilla ◽  
Maria Napolitano ◽  
Gaetano Corazzelli ◽  
Franco Fulciniti
Keyword(s):  
Flow Cytometry ◽  
Fine Needle ◽  
Fine Needle Cytology

scholarly journals OR21-05 Primary Thyroid Lymphoma Developing from a Background of Lymphocytic Thyroiditis: First Report in Mice

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Yoshinori Yasuda ◽  
Fabiana Pani ◽  
Patrizio Caturegli
Keyword(s):  
Flow Cytometry ◽  
Thyroid Cancer ◽  
Thyroid Gland ◽  
Mouse Model ◽  
Corn Oil ◽  
Thyroid Ultrasound ◽  
Papillary Thyroid ◽  
Thyroid Lymphoma ◽  
Lymphocytic Thyroiditis ◽  
Primary Thyroid Lymphoma

Abstract Primary thyroid lymphoma is rare, accounting for less than 5% of all thyroid malignancies. It typically develops in patients with Hashimoto thyroiditis who have approximately a 70 fold higher risk than other patients. The mechanisms underlying the development of thyroid lymphoma remain unclear, and no mouse model has been described. For our studies of papillary thyroid cancer and lymphocytic thyroiditis, we crossed TPO-Cre-ER transgenic mice and hBRAFV600E knock-in mice onto the NOD.H2h4 background to establish TPO-Cre-ER_ hBRAFV600E NOD.H2h4 strain where papillary thyroid cancer is induced by the injection of tamoxifen and thyroiditis by the administration of iodine in the drinking water. Mice injected with corn oil or drinking regular water served as control. In 3 of 121 mice, TPO-Cre-ER_ hBRAFV600E NOD.H2h4 mice injected with corn oil and drinking iodinated water we observed the development of thyroid lymphoma. At about 6 months after the injection of corn oil, these mice developed a marked increase in the size of the thyroid gland, which appeared hypoechoic on thyroid ultrasound. Fine needle aspiration on the thyroid gland under ultrasound was performed, along with measurement of TPO antibodies, H&E thyroid histology, immunohistochemistry, and flow cytometry at the time of sacrifice. Histology established a diagnosis of Hodgkin lymphoma with the typical Reed Sternberg cells. Flow cytometry identified an increased frequency of CD8+ effector memory T cells in the thyroid lymphoma. TPO antibodies were significantly higher in mice with thyroid lymphoma than in those without, perhaps suggesting their utility as predictive biomarkers. In summary, we report a mouse model of thyroid lymphoma that evolves from a background of lymphocytic thyroiditis with a predictable natural course that can be monitored by thyroid ultrasound and TPO antibodies. This model can be used to study the mechanisms and development of thyroid lymphoma in patients.

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