scholarly journals Synaptosomal Lactate Dehydrogenase Isoenzyme Composition Is Shifted toward Aerobic Forms in Primate Brain Evolution

2014 ◽  
Vol 83 (3) ◽  
pp. 216-230 ◽  
Author(s):  
Tetyana Duka ◽  
Sarah M. Anderson ◽  
Zachary Collins ◽  
Mary Ann Raghanti ◽  
John J. Ely ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Brain Evolution ◽  
Dehydrogenase Isoenzyme ◽  
Primate Brain ◽  
Isoenzyme Composition

Lactate dehydrogenase isoenzyme composition of human platelets.

1989 ◽  
Vol 35 (12) ◽  
pp. 2325-2326 ◽  
Author(s):  
D S Miyada ◽  
A Fagin ◽  
H Pirkle ◽  
J Ocariz ◽  
N D Vaziri
Keyword(s):  
Lactate Dehydrogenase ◽  
Human Platelets ◽  
Freezing And Thawing ◽  
Dehydrogenase Isoenzyme ◽  
Ldh Isoenzyme ◽  
Isoenzyme Composition ◽  
The Mean

Abstract The LDH isoenzyme composition of 12 platelet preparations was determined by electrophoresis. The mean (+/- SD) percentages of LDH-1, LDH-2, LDH-3, LDH-4, and LDH-5 were 16.6 +/- 1.7, 30.1 +/- 1.0, 34.2 +/- 1.3, 18.2 +/- 1.3, and 0.9 +/- 1.1, respectively. In comparison with previous data, these data show identical ranking of the prevalence of each isoenzyme but significantly different percentages, particularly of LDH-1 and LDH-4. The release of platelet LDH by freezing and thawing differed little from that by homogenization.

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

Extra Lactate Dehydrogenase Isoenzyme Band in Serum of Patients with Severe Liver Disease

1971 ◽  
Vol 17 (9) ◽  
pp. 882-885 ◽  
Author(s):  
T Lubrano ◽  
A A Dietz ◽  
H M Rubinstein
Keyword(s):  
Liver Disease ◽  
Lactate Dehydrogenase ◽  
Serum Bilirubin ◽  
High Serum ◽  
Severe Liver ◽  
Additional Band ◽  
Dehydrogenase Isoenzyme ◽  
Severe Liver Disease ◽  
Isoenzyme Patterns ◽  
High Serum Bilirubin

Abstract In a study of lactate dehydrogenase isoenzyme patterns in the sera of patients with severe liver disease, who were primarily selected because of an abnormally high serum bilirubin, 42 of 76 patients had an additional band (LDH-T) between isoenzymes 4 and 5 on acrylamide gel. Thirty of the 42 patients died during followup, 24 within a month of recognition of the extra band.

Time-related changes in the diagnostic utility of total lactate dehydrogenase, lactate dehydrogenase isoenzyme-1, and two lactate dehydrogenase isoenzyme-1 ratios in serum after myocardial infarction

1990 ◽  
Vol 36 (7) ◽  
pp. 1317-1322 ◽  
Author(s):  
L V Galbraith ◽  
F Y Leung ◽  
G Jablonsky ◽  
A R Henderson
Keyword(s):  
Myocardial Infarction ◽  
Lactate Dehydrogenase ◽  
Likelihood Ratio ◽  
Roc Curve ◽  
Operating Characteristic ◽  
Negative Likelihood Ratio ◽  
Diagnostic Utility ◽  
Time Intervals ◽  
Dehydrogenase Isoenzyme ◽  
Cardiac Care Unit

Abstract Using receiver-operating characteristic (ROC) curve and likelihood ratio analysis, we examined the diagnostic utility of total lactate dehydrogenase (LD; EC 1.1.1.27) activity (I). LD isoenzyme-1 activity (II), and the LD-1 percentage of total LD activity (III), LD-1 LD-2 (IV), and LD-1/LD-4 (V) in 347 persons admitted to the Cardiac Care Unit (of whom 173 were subsequently proven to have had myocardial infarction). Blood was sampled from these subjects at about 6-h intervals for up to 96 h from the onset of chest pain. Defining an "effective" test as one having an area under the ROC curve of greater than or equal to 0.9, we determined the ranked utility (greatest to least) of these tests as V = IV greater than III greater than II greater than I. Tests III, IV, and V had by this criterion, diagnostic effectiveness equivalent to measurements of creatine kinase-2 in serum but in samples obtained at later time intervals. The decision thresholds for both high (constant) test sensitivity and specificity varied with time, to differing extents, over the entire 96-h period, a finding with important diagnostic implications. We document positive and negative likelihood ratio values for each of these tests throughout the entire period of study.

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