scholarly journals The Current Evidence in Support of Multimodal Treatment of Locally Advanced, Potentially Resectable Esophageal Cancer

2014 ◽  
Vol 32 (1-2) ◽  
pp. 171-175 ◽  
Author(s):  
Johannes Zacherl
Keyword(s):  
Esophageal Cancer ◽  
Multimodal Treatment ◽  
Locally Advanced ◽  
Current Evidence ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer

Multimodal treatment for resectable esophageal cancer

2011 ◽  
Vol 59 (7) ◽  
pp. 461-466 ◽  
Author(s):  
Hiroshi Miyata ◽  
Makoto Yamasaki ◽  
Yukinori Kurokawa ◽  
Shuji Takiguchi ◽  
Kiyokazu Nakajima ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Multimodal Treatment ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer

Practice patterns in the treatment of locally advanced resectable esophageal carcinoma: A national survey of Canadian thoracic surgeons.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14695-e14695
Author(s):  
Gordon Buduhan
Keyword(s):  
Esophageal Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Practice Patterns ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiation ◽  
The Other ◽  
Insufficient Evidence ◽  
Canadian Association ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer

e14695 Background: Many institutions have adopted a multimodality strategy for treating locally advanced resectable esophageal cancer including surgery, chemotherapy and radiation. While many neoadjuvant protocols have been studied, there is no well defined standard treatment. In order to determine current practices and clinician opinions regarding treatment of esophageal cancer, a survey study of practicing Canadian thoracic surgeons was performed. Methods: Members of the Canadian Association of Thoracic Surgeons were contacted by email; those who currently treat esophageal cancer were asked to complete an online survey. Three separate emails were sent to maximize participation. Results: The response rate was 54% (56 /104). Of the respondents, 85% exclusively practiced general thoracic surgery, 87% worked at a University-affiliated hospital. We presented a hypothetical patient with bulky, resectable distal esophageal adenocarcinoma with enlarged paraesophageal lymph nodes (T3N1M0). 54% stated that neoadjuvant chemoradiation followed by surgery was their institution’s treatment of choice, while 33% used neoadjuvant chemotherapy plus surgery. When asked to choose the best treatment for this patient based on available evidence, 33% chose neoadjuvant chemoradiation, 33% favored neoadjuvant chemotherapy, 31% were undecided. Regarding neoadjuvant chemotherapy vs. chemoradiation, 63% strongly agreed or agreed there was insufficient evidence to decide whether or not one treatment was superior to the other. 73% strongly agreed or agreed to support a future randomized trial of preoperative chemotherapy vs. preoperative chemoradiation for esophageal cancer patients. Conclusions: Most Canadian thoracic surgeons use either neoadjuvant chemotherapy or chemoradiation followed by surgery for locally advanced resectable esophageal cancer. There is wide variation in practice patterns with no clear standard approach. 63% feel there is insufficient evidence to decide whether or not one treatment is superior to the other, and the majority support a future trial of neoadjuvant chemotherapy vs. chemoradiation. A pilot study is being planned to determine feasibility.

scholarly journals Phase I evaluation of TNFerade biologic plus chemoradiotherapy before esophagectomy for locally advanced resectable esophageal cancer

2012 ◽  
Vol 75 (6) ◽  
pp. 1139-1146.e2 ◽  
Author(s):  
Kenneth J. Chang ◽  
Tony Reid ◽  
Neil Senzer ◽  
Stephen Swisher ◽  
Harlan Pinto ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Phase I ◽  
Locally Advanced ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer

Prospective Phase II Study of Neoadjuvant Therapy with Cisplatin, 5-Fluorouracil, and Bevacizumab for Locally Advanced Resectable Esophageal Cancer

Onkologie ◽  
2012 ◽  
Vol 35 (7-8) ◽  
pp. 427-431 ◽  
Author(s):  
Efraim Idelevich ◽  
Hanoch Kashtan ◽  
Yoram Klein ◽  
Victor Buevich ◽  
Noa Ben Baruch ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Neoadjuvant Therapy ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Locally Advanced ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer ◽  
Prospective Phase

scholarly journals Neoadjuvant treatments for locally advanced, resectable esophageal cancer: A network meta-analysis

2018 ◽  
Vol 143 (2) ◽  
pp. 430-437 ◽  
Author(s):  
Kelvin K. W. Chan ◽  
Ronak Saluja ◽  
Keemo Delos Santos ◽  
Kelly Lien ◽  
Keya Shah ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer

A Bayesian multiple-treatments meta-analysis of neoadjuvant treatments for locally advanced, resectable esophageal cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 4074-4074
Author(s):  
Kelvin K. Chan ◽  
Keemo Delos Santos ◽  
Keya Shah ◽  
Gemma Cramarossa ◽  
Rebecca Wong
Keyword(s):  
Esophageal Cancer ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer ◽  
Multiple Treatments
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