scholarly journals C-Terminal Agrin Fragment - A New Fast Biomarker for Kidney Function in Renal Transplant Recipients

2013 ◽  
Vol 38 (6) ◽  
pp. 501-508 ◽  
Author(s):  
Dominik Steubl ◽  
Stefan Hettwer ◽  
Wim Vrijbloed ◽  
Pius Dahinden ◽  
Petra Wolf ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Renal biomarkers for assessment of kidney function in renal transplant recipients: how do they compare?

2012 ◽  
Vol 44 (6) ◽  
pp. 1871-1876 ◽  
Author(s):  
Samra Abouchacra ◽  
Ahmed Chaaban ◽  
Raafat Hakim ◽  
Nicole Gebran ◽  
Hanan El-Jack ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Renal Biomarkers

scholarly journals Urinary Excretion of N1-methyl-2-pyridone-5-carboxamide and N1-methylnicotinamide in Renal Transplant Recipients and Donors

2020 ◽  
Vol 9 (2) ◽  
pp. 437 ◽  
Author(s):  
Carolien P. J. Deen ◽  
Anna van der Veen ◽  
António W. Gomes-Neto ◽  
Johanna M. Geleijnse ◽  
Karin J. Borgonjen-van den Berg ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Nutritional Status ◽  
Urinary Excretion ◽  
Kidney Function ◽  
Density Lipoprotein ◽  
Kidney Donation ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cross Sectional ◽  
Kidney Donors

N1-methylnicotinamide (N1-MN) and N1-methyl-2-pyridone-5-carboxamide (2Py) are successive end products of NAD+ catabolism. N1-MN excretion in 24-h urine is the established biomarker of niacin nutritional status, and recently shown to be reduced in renal transplant recipients (RTR). However, it is unclear whether 2Py excretion is increased in this population, and, if so, whether a shift in excretion of N1-MN to 2Py can be attributed to kidney function. Hence, we assessed the 24-h urinary excretion of 2Py and N1-MN in RTR and kidney donors before and after kidney donation, and investigated associations of the urinary ratio of 2Py to N1-MN (2Py/N1-MN) with kidney function, and independent determinants of urinary 2Py/N1-MN in RTR. The urinary excretion of 2Py and N1-MN was measured in a cross-sectional cohort of 660 RTR and 275 healthy kidney donors with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Linear regression analyses were used to investigate associations and determinants of urinary 2Py/N1-MN. Median 2Py excretion was 178.1 (130.3–242.8) μmol/day in RTR, compared to 155.6 (119.6–217.6) μmol/day in kidney donors (p < 0.001). In kidney donors, urinary 2Py/N1-MN increased significantly after kidney donation (4.0 ± 1.4 to 5.2 ± 1.5, respectively; p < 0.001). Smoking, alcohol consumption, diabetes, high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) were identified as independent determinants of urinary 2Py/N1-MN in RTR. In conclusion, the 24-h urinary excretion of 2Py is higher in RTR than in kidney donors, and urinary 2Py/N1-MN increases after kidney donation. As our data furthermore reveal strong associations of urinary 2Py/N1-MN with kidney function, interpretation of both N1-MN and 2Py excretion may be recommended for assessment of niacin nutritional status in conditions of impaired kidney function.

Abstract 326: Group IIA Secretory Phospholipase A 2 Predicts Graft Failure and Cardiovascular Mortality in Renal Transplant Recipients by Mediating Decreased Kidney Function

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Wijtske Annema ◽  
Jan Freark de Boer ◽  
Arne Dikkers ◽  
Stephan J Bakker ◽  
Uwe J Tietge
Keyword(s):  
Renal Transplant ◽  
Transgenic Mice ◽  
Kidney Function ◽  
Graft Failure ◽  
Hazard Ratio ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
All Cause Mortality ◽  
Over Time

The acute phase protein group IIA secretory phospholipase A2 (sPLA2-IIA) has proatherosclerotic properties. The present study prospectively investigated whether plasma sPLA2-IIA levels are associated with graft failure, cardiovascular and all-cause mortality in renal transplant recipients (RTRs), patients known to be susceptible to accelerated atherosclerosis, both in the graft and in the systemic vasculature. In 495 RTRs (median follow-up 7.0 years) sPLA2-IIA was determined at baseline and was significantly higher in RTRs than in healthy controls (median 384 ng/dL [range 86-6951] vs. 185 ng/dL [range 104-271], P<0.001), but lower than in end-stage renal disease patients (median 1053 ng/mL [range 458-2599], P<0.001). Kaplan-Meier analysis demonstrated an increased risk for graft failure (P=0.002), cardiovascular (P<0.001) and all-cause mortality (P<0.001) with increasing gender-stratified quartiles of sPLA2-IIA. Cox regression analyses showed a strong association of sPLA2-IIA with increased risks of graft failure (hazard ratio=1.42[1.11-1.83], P=0.006), cardiovascular (hazard ratio=1.48[1.18-1.85], P=0.001) and all-cause mortality (hazard ratio=1.39[1.17-1.64], P<0.001). However, this association was largely explained by parameters of kidney function. Further analyses in RTRs demonstrated that patients with higher baseline sPLA2-IIA levels showed faster decline in renal function during follow-up. In addition, kidney function in human sPLA2-IIA transgenic mice deteriorated more rapid over time as compared with wild-type controls (urinary albumin:creatinine ratio at 48 weeks of age 774±156 vs. 193±60, P<0.01). In summary, this prospective study demonstrates that sPLA2-IIA is a significant predictive biomarker for the occurrence of chronic graft failure, overall and CVD mortality in RTRs dependent on kidney function. This dependency is explained by sPLA2-IIA impacting negatively on kidney function over time in humans and transgenic mice.

scholarly journals Effect of Pregnancy on Long-Term Kidney Function in Renal Transplant Recipients Treated with Cyclosporine and with Azathioprine

2005 ◽  
Vol 5 (11) ◽  
pp. 2732-2739 ◽  
Author(s):  
Thorsten Fischer ◽  
Hans-Hellmut Neumayer ◽  
Ronald Fischer ◽  
Michael Barenbrock ◽  
Hans P. Schobel ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Renalase Assessment With Regard to Kidney Function, Lipid Disturbances, and Endothelial Dysfunction Parameters in Stable Renal Transplant Recipients

2017 ◽  
Vol 27 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Dijana Stojanovic ◽  
Tatjana Cvetkovic ◽  
Miodrag Stojanovic ◽  
Nikola Stefanovic ◽  
Radmila Velickovic-Radovanovic ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Renal Transplant ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Adiponectin is unrelated to kidney function or injury markers in renal transplant recipients: A one-year follow-up study

2022 ◽  
pp. 106618
Author(s):  
Natalia Serwin ◽  
Daria Adamiak ◽  
Magda Wiśniewska ◽  
Małgorzata Marchelek-Myśliwiec ◽  
Karol Serwin ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Follow Up Study ◽  
One Year

Serum 25-Hydroxyvitamin D Level Is Not Related to Regulatory T Cells or Kidney Function in Renal Transplant Recipients

2018 ◽  
Vol 50 (6) ◽  
pp. 1802-1806
Author(s):  
M. Myszka ◽  
O. Mazanowska ◽  
K. Kościelska-Kasprzak ◽  
D. Bartoszek ◽  
M. Żabińska ◽  
...  
Keyword(s):  
T Cells ◽  
Renal Transplant ◽  
Regulatory T Cells ◽  
Kidney Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
Sign in / Sign up

Export Citation Format

Share Document